Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/8605 |
Resumo: | Centre for Genomic Pathogen Surveillance and the Euro-GASP study group: Sonja Pleininger, Alexander Indra, Irith De Baetselier, Wim Vanden Berghe, Blaženka Hunjak, Tatjana Nemeth Blažić, Panayiota Maikanti-Charalambous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, Lasse Jessen Schwartz, Rita Peetso, Jevgenia Epstein, Jelena Viktorova, Ndeindo Ndeikoundam, Beatrice Bercot, Cécile Bébéar, Florence Lot, Susanne Buder, Klaus Jansen, Vivi Miriagou, Georgios Rigakos, Vasilios Raftopoulos, Eszter Balla, Mária Dudás, Lena Rós Ásmundsdóttir, Guðrún Sigmundsdóttir, Guðrún Svanborg Hauksdóttir, Thorolfur Gudnason, Aoife Colgan, Brendan Crowley, Sinéad Saab, Paola Stefanelli, Anna Carannante, Patrizia Parodi, Gatis Pakarna, Raina Nikiforova, Antra Bormane, Elina Dimina, Monique Perrin, Tamir Abdelrahman, Joël Mossong, Jean-Claude Schmit, Friedrich Mühlschlegel, Christopher Barbara, Francesca Mifsud, Alje Van Dam, Birgit Van Benthem, Maartje Visser, Ineke Linde, Hilde Kløvstad, Dominique Caugant, Beata Młynarczyk-Bonikowska, Jacinta Azevedo, Maria-José Borrego, Marina Lurdes Ramos Nascimento, Peter Pavlik, Irena Klavs, Andreja Murnik, Samo Jeverica, Tanja Kustec, Julio Vázquez Moreno, Asuncion Diaz, Raquel Abad, Inga Velicko, Magnus Unemo, Helen Fifer, Jill Shepherd, Lynsey Patterson |
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Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance studyEuropean Centre for Disease Prevention and ControlCentre for Genomic Pathogen SurveillanceÖrebro University HospitalWellcomeEuropeInfecções Sexualmente TransmissíveisResistência aos AntimicrobianosCentre for Genomic Pathogen Surveillance and the Euro-GASP study group: Sonja Pleininger, Alexander Indra, Irith De Baetselier, Wim Vanden Berghe, Blaženka Hunjak, Tatjana Nemeth Blažić, Panayiota Maikanti-Charalambous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, Lasse Jessen Schwartz, Rita Peetso, Jevgenia Epstein, Jelena Viktorova, Ndeindo Ndeikoundam, Beatrice Bercot, Cécile Bébéar, Florence Lot, Susanne Buder, Klaus Jansen, Vivi Miriagou, Georgios Rigakos, Vasilios Raftopoulos, Eszter Balla, Mária Dudás, Lena Rós Ásmundsdóttir, Guðrún Sigmundsdóttir, Guðrún Svanborg Hauksdóttir, Thorolfur Gudnason, Aoife Colgan, Brendan Crowley, Sinéad Saab, Paola Stefanelli, Anna Carannante, Patrizia Parodi, Gatis Pakarna, Raina Nikiforova, Antra Bormane, Elina Dimina, Monique Perrin, Tamir Abdelrahman, Joël Mossong, Jean-Claude Schmit, Friedrich Mühlschlegel, Christopher Barbara, Francesca Mifsud, Alje Van Dam, Birgit Van Benthem, Maartje Visser, Ineke Linde, Hilde Kløvstad, Dominique Caugant, Beata Młynarczyk-Bonikowska, Jacinta Azevedo, Maria-José Borrego, Marina Lurdes Ramos Nascimento, Peter Pavlik, Irena Klavs, Andreja Murnik, Samo Jeverica, Tanja Kustec, Julio Vázquez Moreno, Asuncion Diaz, Raquel Abad, Inga Velicko, Magnus Unemo, Helen Fifer, Jill Shepherd, Lynsey PattersonBackground: Genomic surveillance using quality-assured whole-genome sequencing (WGS) together with epidemiological and antimicrobial resistance (AMR) data is essential to characterise the circulating Neisseria gonorrhoeae lineages and their association to patient groups (defined by demographic and epidemiological factors). In 2013, the European gonococcal population was characterised genomically for the first time. We describe the European gonococcal population in 2018 and identify emerging or vanishing lineages associated with AMR and epidemiological characteristics of patients, to elucidate recent changes in AMR and gonorrhoea epidemiology in Europe. Methods: We did WGS on 2375 gonococcal isolates from 2018 (mainly Sept 1-Nov 30) in 26 EU and EEA countries. Molecular typing and AMR determinants were extracted from quality-checked genomic data. Association analyses identified links between genomic lineages, AMR, and epidemiological data. Findings: Azithromycin-resistant N gonorrhoeae (8·0% [191/2375] in 2018) is rising in Europe due to the introduction or emergence and subsequent expansion of a novel N gonorrhoeae multi-antigen sequence typing (NG-MAST) genogroup, G12302 (132 [5·6%] of 2375; N gonorrhoeae sequence typing for antimicrobial resistance [NG-STAR] clonal complex [CC]168/63), carrying a mosaic mtrR promoter and mtrD sequence and found in 24 countries in 2018. CC63 was associated with pharyngeal infections in men who have sex with men. Susceptibility to ceftriaxone and cefixime is increasing, as the resistance-associated lineage, NG-MAST G1407 (51 [2·1%] of 2375), is progressively vanishing since 2009-10. Interpretation: Enhanced gonococcal AMR surveillance is imperative worldwide. WGS, linked to epidemiological and AMR data, is essential to elucidate the dynamics in gonorrhoea epidemiology and gonococcal populations as well as to predict AMR. When feasible, WGS should supplement the national and international AMR surveillance programmes to elucidate AMR changes over time. In the EU and EEA, increasing low-level azithromycin resistance could threaten the recommended ceftriaxone-azithromycin dual therapy, and an evidence-based clinical azithromycin resistance breakpoint is needed. Nevertheless, increasing ceftriaxone susceptibility, declining cefixime resistance, and absence of known resistance mutations for new treatments (zoliflodacin, gepotidacin) are promising.This study was supported by the European Centre for Disease Prevention and Control, the Centre for Genomic Pathogen Surveillance, the Li Ka Shing Foundation (Big Data Institute, University of Oxford), the Wellcome Genome Campus, the Foundation for Medical Research at Örebro University Hospital, and grants from Wellcome (098051 and 099202). LSB was funded by Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana (Plan GenT CDEI-06/20-B), Valencia, Spain, and Ministry of Science, Innovation and Universities (PID2020–120113RA-I00), Spain, at the time of analysing and writing this manuscript.ElsevierRepositório Científico do Instituto Nacional de SaúdeSánchez-Busó, LeonorCole, Michelle J.Spiteri, GianfrancoDay, MichaelaJacobsson, SusanneGolparian, DanielSajedi, NoshinYeats, Corin A.Abudahab, KhalilUnderwood, AnthonyBluemel, BenjaminAanensen, David M.Unemo, MagnusPleininger, SonjaIndra, AlexanderDe Baetselier, IrithVanden Berghe, WimHunjak, BlaženkaBlažić, Tatjana NemethMaikanti-Charalambous, PanayiotaPieridou, DespoZákoucká, HanaŽemličková, HelenaHoffmann, SteenCowan, SusanSchwartz, Lasse JessenPeetso, RitaEpstein, JevgeniaViktorova, JelenaNdeikoundam, NdeindoBercot, BeatriceBébéar, CécileLot, FlorenceBuder, SusanneJansen, KlausMiriagou, ViviRigakos, GeorgiosRaftopoulos, VasiliosBalla, EszterDudás, MáriaÁsmundsdóttir, Lena RósSigmundsdóttir, GuðrúnHauksdóttir, Guðrún SvanborgGudnason, ThorolfurColgan, AoifeCrowley, BrendanSaab, SinéadStefanelli, PaolaCarannante, AnnaParodi, PatriziaPakarna, GatisNikiforova, RainaBormane, AntraDimina, ElinaPerrin, MoniqueAbdelrahman, TamirMossong, JoëlSchmit, Jean-ClaudeMühlschlegel, FriedrichBarbara, ChristopherMifsud, FrancescaVan Dam, AljeVan Benthem, BirgitVisser, MaartjeLinde, InekeKløvstad, HildeCaugant, DominiqueMłynarczyk-Bonikowska, BeataAzevedo, JacintaBorrego, Maria-JoséNascimento, Marina Lurdes RamosPavlik, PeterKlavs, IrenaMurnik, AndrejaJeverica, SamoKustec, TanjaVázquez Moreno, JulioDiaz, AsuncionAbad, RaquelVelicko, IngaUnemo, MagnusFifer, HelenShepherd, JillPatterson, Lynsey2023-03-24T12:06:56Z2022-062022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8605engLancet Microbe. 2022 Jun;3(6):e452-e463. doi: 10.1016/S2666-5247(22)00044-1. Epub 2022 May 10.2666-524710.1016/S2666-5247(22)00044-1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:39Zoai:repositorio.insa.pt:10400.18/8605Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:14.973015Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study |
title |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study |
spellingShingle |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study Sánchez-Busó, Leonor European Centre for Disease Prevention and Control Centre for Genomic Pathogen Surveillance Örebro University Hospital Wellcome Europe Infecções Sexualmente Transmissíveis Resistência aos Antimicrobianos |
title_short |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study |
title_full |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study |
title_fullStr |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study |
title_full_unstemmed |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study |
title_sort |
Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study |
author |
Sánchez-Busó, Leonor |
author_facet |
Sánchez-Busó, Leonor Cole, Michelle J. Spiteri, Gianfranco Day, Michaela Jacobsson, Susanne Golparian, Daniel Sajedi, Noshin Yeats, Corin A. Abudahab, Khalil Underwood, Anthony Bluemel, Benjamin Aanensen, David M. Unemo, Magnus Pleininger, Sonja Indra, Alexander De Baetselier, Irith Vanden Berghe, Wim Hunjak, Blaženka Blažić, Tatjana Nemeth Maikanti-Charalambous, Panayiota Pieridou, Despo Zákoucká, Hana Žemličková, Helena Hoffmann, Steen Cowan, Susan Schwartz, Lasse Jessen Peetso, Rita Epstein, Jevgenia Viktorova, Jelena Ndeikoundam, Ndeindo Bercot, Beatrice Bébéar, Cécile Lot, Florence Buder, Susanne Jansen, Klaus Miriagou, Vivi Rigakos, Georgios Raftopoulos, Vasilios Balla, Eszter Dudás, Mária Ásmundsdóttir, Lena Rós Sigmundsdóttir, Guðrún Hauksdóttir, Guðrún Svanborg Gudnason, Thorolfur Colgan, Aoife Crowley, Brendan Saab, Sinéad Stefanelli, Paola Carannante, Anna Parodi, Patrizia Pakarna, Gatis Nikiforova, Raina Bormane, Antra Dimina, Elina Perrin, Monique Abdelrahman, Tamir Mossong, Joël Schmit, Jean-Claude Mühlschlegel, Friedrich Barbara, Christopher Mifsud, Francesca Van Dam, Alje Van Benthem, Birgit Visser, Maartje Linde, Ineke Kløvstad, Hilde Caugant, Dominique Młynarczyk-Bonikowska, Beata Azevedo, Jacinta Borrego, Maria-José Nascimento, Marina Lurdes Ramos Pavlik, Peter Klavs, Irena Murnik, Andreja Jeverica, Samo Kustec, Tanja Vázquez Moreno, Julio Diaz, Asuncion Abad, Raquel Velicko, Inga Fifer, Helen Shepherd, Jill Patterson, Lynsey |
author_role |
author |
author2 |
Cole, Michelle J. Spiteri, Gianfranco Day, Michaela Jacobsson, Susanne Golparian, Daniel Sajedi, Noshin Yeats, Corin A. Abudahab, Khalil Underwood, Anthony Bluemel, Benjamin Aanensen, David M. Unemo, Magnus Pleininger, Sonja Indra, Alexander De Baetselier, Irith Vanden Berghe, Wim Hunjak, Blaženka Blažić, Tatjana Nemeth Maikanti-Charalambous, Panayiota Pieridou, Despo Zákoucká, Hana Žemličková, Helena Hoffmann, Steen Cowan, Susan Schwartz, Lasse Jessen Peetso, Rita Epstein, Jevgenia Viktorova, Jelena Ndeikoundam, Ndeindo Bercot, Beatrice Bébéar, Cécile Lot, Florence Buder, Susanne Jansen, Klaus Miriagou, Vivi Rigakos, Georgios Raftopoulos, Vasilios Balla, Eszter Dudás, Mária Ásmundsdóttir, Lena Rós Sigmundsdóttir, Guðrún Hauksdóttir, Guðrún Svanborg Gudnason, Thorolfur Colgan, Aoife Crowley, Brendan Saab, Sinéad Stefanelli, Paola Carannante, Anna Parodi, Patrizia Pakarna, Gatis Nikiforova, Raina Bormane, Antra Dimina, Elina Perrin, Monique Abdelrahman, Tamir Mossong, Joël Schmit, Jean-Claude Mühlschlegel, Friedrich Barbara, Christopher Mifsud, Francesca Van Dam, Alje Van Benthem, Birgit Visser, Maartje Linde, Ineke Kløvstad, Hilde Caugant, Dominique Młynarczyk-Bonikowska, Beata Azevedo, Jacinta Borrego, Maria-José Nascimento, Marina Lurdes Ramos Pavlik, Peter Klavs, Irena Murnik, Andreja Jeverica, Samo Kustec, Tanja Vázquez Moreno, Julio Diaz, Asuncion Abad, Raquel Velicko, Inga Fifer, Helen Shepherd, Jill Patterson, Lynsey |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Sánchez-Busó, Leonor Cole, Michelle J. Spiteri, Gianfranco Day, Michaela Jacobsson, Susanne Golparian, Daniel Sajedi, Noshin Yeats, Corin A. Abudahab, Khalil Underwood, Anthony Bluemel, Benjamin Aanensen, David M. Unemo, Magnus Pleininger, Sonja Indra, Alexander De Baetselier, Irith Vanden Berghe, Wim Hunjak, Blaženka Blažić, Tatjana Nemeth Maikanti-Charalambous, Panayiota Pieridou, Despo Zákoucká, Hana Žemličková, Helena Hoffmann, Steen Cowan, Susan Schwartz, Lasse Jessen Peetso, Rita Epstein, Jevgenia Viktorova, Jelena Ndeikoundam, Ndeindo Bercot, Beatrice Bébéar, Cécile Lot, Florence Buder, Susanne Jansen, Klaus Miriagou, Vivi Rigakos, Georgios Raftopoulos, Vasilios Balla, Eszter Dudás, Mária Ásmundsdóttir, Lena Rós Sigmundsdóttir, Guðrún Hauksdóttir, Guðrún Svanborg Gudnason, Thorolfur Colgan, Aoife Crowley, Brendan Saab, Sinéad Stefanelli, Paola Carannante, Anna Parodi, Patrizia Pakarna, Gatis Nikiforova, Raina Bormane, Antra Dimina, Elina Perrin, Monique Abdelrahman, Tamir Mossong, Joël Schmit, Jean-Claude Mühlschlegel, Friedrich Barbara, Christopher Mifsud, Francesca Van Dam, Alje Van Benthem, Birgit Visser, Maartje Linde, Ineke Kløvstad, Hilde Caugant, Dominique Młynarczyk-Bonikowska, Beata Azevedo, Jacinta Borrego, Maria-José Nascimento, Marina Lurdes Ramos Pavlik, Peter Klavs, Irena Murnik, Andreja Jeverica, Samo Kustec, Tanja Vázquez Moreno, Julio Diaz, Asuncion Abad, Raquel Velicko, Inga Unemo, Magnus Fifer, Helen Shepherd, Jill Patterson, Lynsey |
dc.subject.por.fl_str_mv |
European Centre for Disease Prevention and Control Centre for Genomic Pathogen Surveillance Örebro University Hospital Wellcome Europe Infecções Sexualmente Transmissíveis Resistência aos Antimicrobianos |
topic |
European Centre for Disease Prevention and Control Centre for Genomic Pathogen Surveillance Örebro University Hospital Wellcome Europe Infecções Sexualmente Transmissíveis Resistência aos Antimicrobianos |
description |
Centre for Genomic Pathogen Surveillance and the Euro-GASP study group: Sonja Pleininger, Alexander Indra, Irith De Baetselier, Wim Vanden Berghe, Blaženka Hunjak, Tatjana Nemeth Blažić, Panayiota Maikanti-Charalambous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, Lasse Jessen Schwartz, Rita Peetso, Jevgenia Epstein, Jelena Viktorova, Ndeindo Ndeikoundam, Beatrice Bercot, Cécile Bébéar, Florence Lot, Susanne Buder, Klaus Jansen, Vivi Miriagou, Georgios Rigakos, Vasilios Raftopoulos, Eszter Balla, Mária Dudás, Lena Rós Ásmundsdóttir, Guðrún Sigmundsdóttir, Guðrún Svanborg Hauksdóttir, Thorolfur Gudnason, Aoife Colgan, Brendan Crowley, Sinéad Saab, Paola Stefanelli, Anna Carannante, Patrizia Parodi, Gatis Pakarna, Raina Nikiforova, Antra Bormane, Elina Dimina, Monique Perrin, Tamir Abdelrahman, Joël Mossong, Jean-Claude Schmit, Friedrich Mühlschlegel, Christopher Barbara, Francesca Mifsud, Alje Van Dam, Birgit Van Benthem, Maartje Visser, Ineke Linde, Hilde Kløvstad, Dominique Caugant, Beata Młynarczyk-Bonikowska, Jacinta Azevedo, Maria-José Borrego, Marina Lurdes Ramos Nascimento, Peter Pavlik, Irena Klavs, Andreja Murnik, Samo Jeverica, Tanja Kustec, Julio Vázquez Moreno, Asuncion Diaz, Raquel Abad, Inga Velicko, Magnus Unemo, Helen Fifer, Jill Shepherd, Lynsey Patterson |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06 2022-06-01T00:00:00Z 2023-03-24T12:06:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8605 |
url |
http://hdl.handle.net/10400.18/8605 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lancet Microbe. 2022 Jun;3(6):e452-e463. doi: 10.1016/S2666-5247(22)00044-1. Epub 2022 May 10. 2666-5247 10.1016/S2666-5247(22)00044-1 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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