Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/145139 |
Resumo: | Funding Information: We want to thank Frank Tang, Bin Lin, Mike Cohen and the rest of the Google speech team for their insightful discussions and inputs. Publisher Copyright: Copyright © 2022 Miranda, Pingarilho, Pimentel, Martins, Kaiser, Seguin-Devaux, Paredes, Zazzi, Incardona and Abecasis. |
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Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019A Comparison Between the Populations of Late Presenters and Non-late Presentersacquired drug resistanceHIV-1 infectionlate presentersnon-late presenterstransmitted drug resistanceMicrobiologyInfectious DiseasesEpidemiologySDG 3 - Good Health and Well-beingFunding Information: We want to thank Frank Tang, Bin Lin, Mike Cohen and the rest of the Google speech team for their insightful discussions and inputs. Publisher Copyright: Copyright © 2022 Miranda, Pingarilho, Pimentel, Martins, Kaiser, Seguin-Devaux, Paredes, Zazzi, Incardona and Abecasis.Background: The increased use of antiretroviral therapy (ART) has decreased mortality and morbidity of HIV-1 infected people but increasing levels of HIV drug resistance threatens the success of ART regimens. Conversely, late presentation can impact treatment outcomes, health costs, and potential transmission of HIV. Objective: To describe the patterns of transmitted drug resistance (TDR) and acquired drug resistance (ADR) in HIV-1 infected patients followed in Europe, to compare its patterns in late presenters (LP) vs non-late presenters (NLP), and to analyze the most prevalent drug resistance mutations among HIV-1 subtypes. Methods: Our study included clinical, socio-demographic, and genotypic information from 26,973 HIV-1 infected patients from the EuResist Integrated Database (EIDB) between 1981 and 2019. Results: Among the 26,973 HIV-1 infected patients in the analysis, 11,581 (42.9%) were ART-naïve patients and 15,392 (57.1%) were ART-experienced. The median age was 37 (IQR: 27.0–45.0) years old and 72.6% were males. The main transmission route was through heterosexual contact (34.9%) and 81.7% of patients originated from Western Europe. 71.9% of patients were infected by subtype B and 54.8% of patients were classified as LP. The overall prevalence of TDR was 12.8% and presented an overall decreasing trend (p for trend < 0.001), the ADR prevalence was 68.5% also with a decreasing trend (p for trend < 0.001). For LP and NLP, the TDR prevalence was 12.3 and 12.6%, respectively, while for ADR, 69.9 and 68.2%, respectively. The most prevalent TDR drug resistance mutations, in both LP and NLP, were K103N/S, T215rev, T215FY, M184I/V, M41I/L, M46I/L, and L90M. Conclusion: Our study showed that the overall TDR (12.8%) and ADR (68.5%) presented decreasing trends during the study time period. For LP, the overall TDR was slightly lower than for NLP (12.3 vs 12.6%, respectively); while this pattern was opposite for ADR (LP slightly higher than NLP). We suggest that these differences, in the case of TDR, can be related to the dynamics of fixation of drug resistance mutations; and in the case of ADR with the more frequent therapeutic failure in LPs.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)TB, HIV and opportunistic diseases and pathogens (THOP)Population health, policies and services (PPS)RUNMiranda, Mafalda N.S.Pingarilho, MartaPimentel, VictorMartins, Maria do Rosário O.Kaiser, RolfSeguin-Devaux, CaroleParedes, RogerZazzi, MaurizioIncardona, FrancescaAbecasis, Ana B.2022-10-31T23:41:11Z2022-04-132022-04-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/145139eng1664-302XPURE: 46702740https://doi.org/10.3389/fmicb.2022.846943info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:06:19Zoai:run.unl.pt:10362/145139Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:06:19Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 A Comparison Between the Populations of Late Presenters and Non-late Presenters |
| title |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 |
| spellingShingle |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 Miranda, Mafalda N.S. acquired drug resistance HIV-1 infection late presenters non-late presenters transmitted drug resistance Microbiology Infectious Diseases Epidemiology SDG 3 - Good Health and Well-being |
| title_short |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 |
| title_full |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 |
| title_fullStr |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 |
| title_full_unstemmed |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 |
| title_sort |
Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019 |
| author |
Miranda, Mafalda N.S. |
| author_facet |
Miranda, Mafalda N.S. Pingarilho, Marta Pimentel, Victor Martins, Maria do Rosário O. Kaiser, Rolf Seguin-Devaux, Carole Paredes, Roger Zazzi, Maurizio Incardona, Francesca Abecasis, Ana B. |
| author_role |
author |
| author2 |
Pingarilho, Marta Pimentel, Victor Martins, Maria do Rosário O. Kaiser, Rolf Seguin-Devaux, Carole Paredes, Roger Zazzi, Maurizio Incardona, Francesca Abecasis, Ana B. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) TB, HIV and opportunistic diseases and pathogens (THOP) Population health, policies and services (PPS) RUN |
| dc.contributor.author.fl_str_mv |
Miranda, Mafalda N.S. Pingarilho, Marta Pimentel, Victor Martins, Maria do Rosário O. Kaiser, Rolf Seguin-Devaux, Carole Paredes, Roger Zazzi, Maurizio Incardona, Francesca Abecasis, Ana B. |
| dc.subject.por.fl_str_mv |
acquired drug resistance HIV-1 infection late presenters non-late presenters transmitted drug resistance Microbiology Infectious Diseases Epidemiology SDG 3 - Good Health and Well-being |
| topic |
acquired drug resistance HIV-1 infection late presenters non-late presenters transmitted drug resistance Microbiology Infectious Diseases Epidemiology SDG 3 - Good Health and Well-being |
| description |
Funding Information: We want to thank Frank Tang, Bin Lin, Mike Cohen and the rest of the Google speech team for their insightful discussions and inputs. Publisher Copyright: Copyright © 2022 Miranda, Pingarilho, Pimentel, Martins, Kaiser, Seguin-Devaux, Paredes, Zazzi, Incardona and Abecasis. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-10-31T23:41:11Z 2022-04-13 2022-04-13T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/145139 |
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http://hdl.handle.net/10362/145139 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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1664-302X PURE: 46702740 https://doi.org/10.3389/fmicb.2022.846943 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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