Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019

Detalhes bibliográficos
Autor(a) principal: Miranda, Mafalda N.S.
Data de Publicação: 2022
Outros Autores: Pingarilho, Marta, Pimentel, Victor, Martins, Maria do Rosário O., Kaiser, Rolf, Seguin-Devaux, Carole, Paredes, Roger, Zazzi, Maurizio, Incardona, Francesca, Abecasis, Ana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/145139
Resumo: Funding Information: We want to thank Frank Tang, Bin Lin, Mike Cohen and the rest of the Google speech team for their insightful discussions and inputs. Publisher Copyright: Copyright © 2022 Miranda, Pingarilho, Pimentel, Martins, Kaiser, Seguin-Devaux, Paredes, Zazzi, Incardona and Abecasis.
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spelling Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019A Comparison Between the Populations of Late Presenters and Non-late Presentersacquired drug resistanceHIV-1 infectionlate presentersnon-late presenterstransmitted drug resistanceMicrobiologyInfectious DiseasesEpidemiologySDG 3 - Good Health and Well-beingFunding Information: We want to thank Frank Tang, Bin Lin, Mike Cohen and the rest of the Google speech team for their insightful discussions and inputs. Publisher Copyright: Copyright © 2022 Miranda, Pingarilho, Pimentel, Martins, Kaiser, Seguin-Devaux, Paredes, Zazzi, Incardona and Abecasis.Background: The increased use of antiretroviral therapy (ART) has decreased mortality and morbidity of HIV-1 infected people but increasing levels of HIV drug resistance threatens the success of ART regimens. Conversely, late presentation can impact treatment outcomes, health costs, and potential transmission of HIV. Objective: To describe the patterns of transmitted drug resistance (TDR) and acquired drug resistance (ADR) in HIV-1 infected patients followed in Europe, to compare its patterns in late presenters (LP) vs non-late presenters (NLP), and to analyze the most prevalent drug resistance mutations among HIV-1 subtypes. Methods: Our study included clinical, socio-demographic, and genotypic information from 26,973 HIV-1 infected patients from the EuResist Integrated Database (EIDB) between 1981 and 2019. Results: Among the 26,973 HIV-1 infected patients in the analysis, 11,581 (42.9%) were ART-naïve patients and 15,392 (57.1%) were ART-experienced. The median age was 37 (IQR: 27.0–45.0) years old and 72.6% were males. The main transmission route was through heterosexual contact (34.9%) and 81.7% of patients originated from Western Europe. 71.9% of patients were infected by subtype B and 54.8% of patients were classified as LP. The overall prevalence of TDR was 12.8% and presented an overall decreasing trend (p for trend < 0.001), the ADR prevalence was 68.5% also with a decreasing trend (p for trend < 0.001). For LP and NLP, the TDR prevalence was 12.3 and 12.6%, respectively, while for ADR, 69.9 and 68.2%, respectively. The most prevalent TDR drug resistance mutations, in both LP and NLP, were K103N/S, T215rev, T215FY, M184I/V, M41I/L, M46I/L, and L90M. Conclusion: Our study showed that the overall TDR (12.8%) and ADR (68.5%) presented decreasing trends during the study time period. For LP, the overall TDR was slightly lower than for NLP (12.3 vs 12.6%, respectively); while this pattern was opposite for ADR (LP slightly higher than NLP). We suggest that these differences, in the case of TDR, can be related to the dynamics of fixation of drug resistance mutations; and in the case of ADR with the more frequent therapeutic failure in LPs.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)TB, HIV and opportunistic diseases and pathogens (THOP)Population health, policies and services (PPS)RUNMiranda, Mafalda N.S.Pingarilho, MartaPimentel, VictorMartins, Maria do Rosário O.Kaiser, RolfSeguin-Devaux, CaroleParedes, RogerZazzi, MaurizioIncardona, FrancescaAbecasis, Ana B.2022-10-31T23:41:11Z2022-04-132022-04-13T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/145139eng1664-302XPURE: 46702740https://doi.org/10.3389/fmicb.2022.846943info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:25:16Zoai:run.unl.pt:10362/145139Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:51:55.468658Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
A Comparison Between the Populations of Late Presenters and Non-late Presenters
title Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
spellingShingle Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
Miranda, Mafalda N.S.
acquired drug resistance
HIV-1 infection
late presenters
non-late presenters
transmitted drug resistance
Microbiology
Infectious Diseases
Epidemiology
SDG 3 - Good Health and Well-being
title_short Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
title_full Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
title_fullStr Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
title_full_unstemmed Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
title_sort Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019
author Miranda, Mafalda N.S.
author_facet Miranda, Mafalda N.S.
Pingarilho, Marta
Pimentel, Victor
Martins, Maria do Rosário O.
Kaiser, Rolf
Seguin-Devaux, Carole
Paredes, Roger
Zazzi, Maurizio
Incardona, Francesca
Abecasis, Ana B.
author_role author
author2 Pingarilho, Marta
Pimentel, Victor
Martins, Maria do Rosário O.
Kaiser, Rolf
Seguin-Devaux, Carole
Paredes, Roger
Zazzi, Maurizio
Incardona, Francesca
Abecasis, Ana B.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
TB, HIV and opportunistic diseases and pathogens (THOP)
Population health, policies and services (PPS)
RUN
dc.contributor.author.fl_str_mv Miranda, Mafalda N.S.
Pingarilho, Marta
Pimentel, Victor
Martins, Maria do Rosário O.
Kaiser, Rolf
Seguin-Devaux, Carole
Paredes, Roger
Zazzi, Maurizio
Incardona, Francesca
Abecasis, Ana B.
dc.subject.por.fl_str_mv acquired drug resistance
HIV-1 infection
late presenters
non-late presenters
transmitted drug resistance
Microbiology
Infectious Diseases
Epidemiology
SDG 3 - Good Health and Well-being
topic acquired drug resistance
HIV-1 infection
late presenters
non-late presenters
transmitted drug resistance
Microbiology
Infectious Diseases
Epidemiology
SDG 3 - Good Health and Well-being
description Funding Information: We want to thank Frank Tang, Bin Lin, Mike Cohen and the rest of the Google speech team for their insightful discussions and inputs. Publisher Copyright: Copyright © 2022 Miranda, Pingarilho, Pimentel, Martins, Kaiser, Seguin-Devaux, Paredes, Zazzi, Incardona and Abecasis.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-31T23:41:11Z
2022-04-13
2022-04-13T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145139
url http://hdl.handle.net/10362/145139
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1664-302X
PURE: 46702740
https://doi.org/10.3389/fmicb.2022.846943
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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