Dealing with the nucleus during cell migration

Detalhes bibliográficos
Autor(a) principal: Calero-Cuenca, Francisco J.
Data de Publicação: 2018
Outros Autores: Janota, Cátia, Gomes, Edgar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49566
Resumo: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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spelling Dealing with the nucleus during cell migration© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).The position of the nucleus within cells is a key event during cell migration. The movement and positioning of the nucleus strongly impacts cell migration. Notably, the last two years largely contributed to emphasise the dynamicity of the nucleus-cytoskeleton interactions that occur during cell migration. Nuclei are under continuous tension from opposing intracellular forces and its tether to the cytoskeleton can be regulated at different levels. Interestingly, it was showed how nuclear positioning is highly related to cell function. In most migrating cells, including cancer cells, the nucleus can be the rate limiting step of cell migration and is placed away from the leading edge. By contrast, leukocytes position their nucleus close to the lamellipodia at the leading edge, and the nucleus contributes to drilling through the endothelium. Differences in cell migration in 2D versus 3D environments are also evident. The mechanisms and forces at play during nuclear positioning and translocation are clearly affected by the nature of the substrate. As such nuclear positioning during cell migration can vary between cell types and environments. In this review we aim to give an overview of the latest discoveries in the field revealing how nuclear positioning is tightly regulated, not only by intrinsic nuclear properties, such as deformability, nuclear envelope content or nucleus-cytoskeleton connectivity, but also by the microenvironment.This work was supported by the European Research Council, EMBO installation, LISBOA-01-0145-FEDER-007391, project cofunded by FEDER, through POR Lisboa 2020 — Programa Operacional Regional de Lisboa, Portugal 2020 and Fundação para a Ciência e a Tecnologia.ElsevierRepositório da Universidade de LisboaCalero-Cuenca, Francisco J.Janota, CátiaGomes, Edgar2021-09-21T15:43:41Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49566engCurr Opin Cell Biol. 2018 Feb;50:35-410955-067410.1016/j.ceb.2018.01.0141879-0410info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:27Zoai:repositorio.ul.pt:10451/49566Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:11.717419Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dealing with the nucleus during cell migration
title Dealing with the nucleus during cell migration
spellingShingle Dealing with the nucleus during cell migration
Calero-Cuenca, Francisco J.
title_short Dealing with the nucleus during cell migration
title_full Dealing with the nucleus during cell migration
title_fullStr Dealing with the nucleus during cell migration
title_full_unstemmed Dealing with the nucleus during cell migration
title_sort Dealing with the nucleus during cell migration
author Calero-Cuenca, Francisco J.
author_facet Calero-Cuenca, Francisco J.
Janota, Cátia
Gomes, Edgar
author_role author
author2 Janota, Cátia
Gomes, Edgar
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Calero-Cuenca, Francisco J.
Janota, Cátia
Gomes, Edgar
description © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2021-09-21T15:43:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49566
url http://hdl.handle.net/10451/49566
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Curr Opin Cell Biol. 2018 Feb;50:35-41
0955-0674
10.1016/j.ceb.2018.01.014
1879-0410
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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