Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects

Detalhes bibliográficos
Autor(a) principal: Pereira, Carla
Data de Publicação: 2016
Outros Autores: Barros, Lillian, Ferreira, Isabel C.F.R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/13345
Resumo: The liver is one of the most important organs of human body, being involved in several vital functions and regulation of physiological processes. Given its pivotal role in the excretion of waste metabolites and drugs detoxification, the liver is often subjected to oxidative stress that leads to lipid peroxidation and severe cellular damage. The conventional treatments of liver diseases such as cirrhosis, fatty liver and chronic hepatitis are frequently inadequate due to side effects caused by hepatotoxic chemical drugs. To overcome this problematic paradox, medicinal plants, owing to their natural richness in phenolic compounds, have been intensively exploited concerning their extracts and fraction composition in order to find bioactive compounds that could be isolated and applied in the treatment of liver ailments. The present review aimed to collect the main results of recent studies carried out in this field and systematize the information for a better understanding of the hepatoprotective capacity of medicinal plants in in vitro and in vivo systems. Generally, the assessed plant extracts revealed good hepatoprotective properties, justifying the fractionation and further isolation of phenolic compounds from different parts of the plant. Twenty-five phenolic compounds, including flavonoids, lignan compounds, phenolic acids and other phenolic compounds, have been isolated and identified, and proved to be effective in the prevention and/or treatment of chemically induced liver damage. In this perspective, the use of medicinal plant extracts, fractions and phenolic compounds seems to be a promising strategy to avoid side effects caused by hepatotoxic chemicals.
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spelling Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effectsHepatoprotective plantsExtractsFractionsIsolated phenolic compoundsThe liver is one of the most important organs of human body, being involved in several vital functions and regulation of physiological processes. Given its pivotal role in the excretion of waste metabolites and drugs detoxification, the liver is often subjected to oxidative stress that leads to lipid peroxidation and severe cellular damage. The conventional treatments of liver diseases such as cirrhosis, fatty liver and chronic hepatitis are frequently inadequate due to side effects caused by hepatotoxic chemical drugs. To overcome this problematic paradox, medicinal plants, owing to their natural richness in phenolic compounds, have been intensively exploited concerning their extracts and fraction composition in order to find bioactive compounds that could be isolated and applied in the treatment of liver ailments. The present review aimed to collect the main results of recent studies carried out in this field and systematize the information for a better understanding of the hepatoprotective capacity of medicinal plants in in vitro and in vivo systems. Generally, the assessed plant extracts revealed good hepatoprotective properties, justifying the fractionation and further isolation of phenolic compounds from different parts of the plant. Twenty-five phenolic compounds, including flavonoids, lignan compounds, phenolic acids and other phenolic compounds, have been isolated and identified, and proved to be effective in the prevention and/or treatment of chemically induced liver damage. In this perspective, the use of medicinal plant extracts, fractions and phenolic compounds seems to be a promising strategy to avoid side effects caused by hepatotoxic chemicals.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support to the research centre CIMO (PEst-OE/AGR/UI0690/2014) and L. Barros researcher contract under “Programa Compromisso com Ciência-2008.John Wiley and SonsBiblioteca Digital do IPBPereira, CarlaBarros, LillianFerreira, Isabel C.F.R.2016-09-29T16:25:25Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/10198/13345engPereira, Carla: Barros, Lillian; Ferreira, Isabel C.F.R. (2016). Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects. Journal of the Science of Food and Agriculture. ISSN 0022-5142. 94:4, p. 1068-10840022-514210.1002/jsfa.7446info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:31:11Zoai:bibliotecadigital.ipb.pt:10198/13345Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:03:26.178930Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
title Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
spellingShingle Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
Pereira, Carla
Hepatoprotective plants
Extracts
Fractions
Isolated phenolic compounds
title_short Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
title_full Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
title_fullStr Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
title_full_unstemmed Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
title_sort Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects
author Pereira, Carla
author_facet Pereira, Carla
Barros, Lillian
Ferreira, Isabel C.F.R.
author_role author
author2 Barros, Lillian
Ferreira, Isabel C.F.R.
author2_role author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Pereira, Carla
Barros, Lillian
Ferreira, Isabel C.F.R.
dc.subject.por.fl_str_mv Hepatoprotective plants
Extracts
Fractions
Isolated phenolic compounds
topic Hepatoprotective plants
Extracts
Fractions
Isolated phenolic compounds
description The liver is one of the most important organs of human body, being involved in several vital functions and regulation of physiological processes. Given its pivotal role in the excretion of waste metabolites and drugs detoxification, the liver is often subjected to oxidative stress that leads to lipid peroxidation and severe cellular damage. The conventional treatments of liver diseases such as cirrhosis, fatty liver and chronic hepatitis are frequently inadequate due to side effects caused by hepatotoxic chemical drugs. To overcome this problematic paradox, medicinal plants, owing to their natural richness in phenolic compounds, have been intensively exploited concerning their extracts and fraction composition in order to find bioactive compounds that could be isolated and applied in the treatment of liver ailments. The present review aimed to collect the main results of recent studies carried out in this field and systematize the information for a better understanding of the hepatoprotective capacity of medicinal plants in in vitro and in vivo systems. Generally, the assessed plant extracts revealed good hepatoprotective properties, justifying the fractionation and further isolation of phenolic compounds from different parts of the plant. Twenty-five phenolic compounds, including flavonoids, lignan compounds, phenolic acids and other phenolic compounds, have been isolated and identified, and proved to be effective in the prevention and/or treatment of chemically induced liver damage. In this perspective, the use of medicinal plant extracts, fractions and phenolic compounds seems to be a promising strategy to avoid side effects caused by hepatotoxic chemicals.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-29T16:25:25Z
2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/13345
url http://hdl.handle.net/10198/13345
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pereira, Carla: Barros, Lillian; Ferreira, Isabel C.F.R. (2016). Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects. Journal of the Science of Food and Agriculture. ISSN 0022-5142. 94:4, p. 1068-1084
0022-5142
10.1002/jsfa.7446
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dc.publisher.none.fl_str_mv John Wiley and Sons
publisher.none.fl_str_mv John Wiley and Sons
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