The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system

• Autor(a) principal: Marques, Fernanda
• Data de Publicação: 2015
• Outros Autores: Sousa, João Carlos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/41038
• topic: Choroid plexus; Epithelial cell; Lipocalin 2; Inflammation; Multiple sclerosis; Experimental autoimmune encephalomyelitis; Astrocytes; Cerebrospinal fluid; experimental autoimmune; encephalomyelitis; Ciências Médicas::Medicina Básica; Science & Technology

The blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB) form the barriers of the brain. These barriers are essential not only for the protection of the brain, but also in regulating the exchange of cells and molecules in and out of the brain. The choroid plexus (CP) epithelial cells and the arachnoid membrane form the BCSFB. The CP is structurally divided into two independent compartments: one formed by a unique and continuous line of epithelial cells that rest upon a basal lamina; and, a second consisting of a central core formed by connective and highly vascularized tissue populated by diverse cell types (fibroblasts, macrophages and dendritic cells). Here, we review how the CP transcriptome and secretome vary depending on the nature and duration of the stimuli to which the CP is exposed. Specifically, when the peripheral stimulation is acute the CP response is rapid, strong and transient, whereas if the stimulation is sustained in time the CP response persists but it is weaker. Furthermore, not all of the epithelium responds at the same time to peripheral stimulation, suggesting the existence of a synchrony system between individual CP epithelial cells.