Adaptive potential of hybridization among malaria vectors
| Autor(a) principal: | |
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| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://doi.org/10.1371/journal.pone.0127804 |
Resumo: | PMID: 26047479 WOS:000355652200031 |
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Adaptive potential of hybridization among malaria vectorsIntrogression at the immune locus TEP1 between Anopheles coluzzii and A. gambiae in 'Far-West' AfricaEcology, Evolution, Behavior and SystematicsGeneticsInsect ScienceInfectious DiseasesImmunologySDG 3 - Good Health and Well-beingPMID: 26047479 WOS:000355652200031"Far-West" Africa is known to be a secondary contact zone between the two major malaria vectors Anopheles coluzzii and A. gambiae. We investigated gene-flow and potentially adaptive introgression between these species along a west-to-east transect in Guinea Bissau, the putative core of this hybrid zone. To evaluate the extent and direction of gene flow, we genotyped site 702 in Intron-1 of the para Voltage-Gated Sodium Channel gene, a species-diagnostic nucleotide position throughout most of A. coluzzii and A. gambiae sympatric range. We also analyzed polymorphism in the thioester-binding domain (TED) of the innate immunity-linked thioester-containing protein 1 (TEP1) to investigate whether elevated hybridization might facilitate the exchange of variants linked to adaptive immunity and Plasmodium refractoriness. Our results confirm asymmetric introgression of genetic material from A. coluzzii to A. gambiae and disruption of linkage between the centromeric "genomic islands" of inter-specific divergence. We report that A. gambiae from the Guinean hybrid zone possesses an introgressed TEP1 resistant allelic class, found exclusively in A. coluzzii elsewhere and apparently swept to fixation in West Africa (i.e. Mali and Burkina Faso). However, no detectable fixation of this allele was found in Guinea Bissau, which may suggest that ecological pressures driving segregation between the two species in larval habitats in this region may be different from those experienced in northern and more arid parts of the species' range. Finally, our results also suggest a genetic subdivision between coastal and inland A. gambiae Guinean populations and provide clues on the importance of ecological factors in intra-specific differentiation processes.Instituto de Higiene e Medicina Tropical (IHMT)Centro de Malária e outras Doenças Tropicais (CMDT)RUNMancini, EmilianoSpinaci, Maria IdaGordicho, VascoCaputo, BeniaminoPombi, MarcoVicente, José LuisDinis, JoãoRodrigues, AmabéliaPetrarca, VincenzoWeetman, DavidPinto, JoãoTorre, Alessandra Della2018-05-14T22:02:06Z2015-06-052015-06-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1371/journal.pone.0127804eng1932-6203PURE: 1728870http://www.scopus.com/inward/record.url?scp=84934942312&partnerID=8YFLogxKhttps://doi.org/10.1371/journal.pone.0127804info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:20:29Zoai:run.unl.pt:10362/36939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:42.875274Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Adaptive potential of hybridization among malaria vectors Introgression at the immune locus TEP1 between Anopheles coluzzii and A. gambiae in 'Far-West' Africa |
| title |
Adaptive potential of hybridization among malaria vectors |
| spellingShingle |
Adaptive potential of hybridization among malaria vectors Mancini, Emiliano Ecology, Evolution, Behavior and Systematics Genetics Insect Science Infectious Diseases Immunology SDG 3 - Good Health and Well-being |
| title_short |
Adaptive potential of hybridization among malaria vectors |
| title_full |
Adaptive potential of hybridization among malaria vectors |
| title_fullStr |
Adaptive potential of hybridization among malaria vectors |
| title_full_unstemmed |
Adaptive potential of hybridization among malaria vectors |
| title_sort |
Adaptive potential of hybridization among malaria vectors |
| author |
Mancini, Emiliano |
| author_facet |
Mancini, Emiliano Spinaci, Maria Ida Gordicho, Vasco Caputo, Beniamino Pombi, Marco Vicente, José Luis Dinis, João Rodrigues, Amabélia Petrarca, Vincenzo Weetman, David Pinto, João Torre, Alessandra Della |
| author_role |
author |
| author2 |
Spinaci, Maria Ida Gordicho, Vasco Caputo, Beniamino Pombi, Marco Vicente, José Luis Dinis, João Rodrigues, Amabélia Petrarca, Vincenzo Weetman, David Pinto, João Torre, Alessandra Della |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Centro de Malária e outras Doenças Tropicais (CMDT) RUN |
| dc.contributor.author.fl_str_mv |
Mancini, Emiliano Spinaci, Maria Ida Gordicho, Vasco Caputo, Beniamino Pombi, Marco Vicente, José Luis Dinis, João Rodrigues, Amabélia Petrarca, Vincenzo Weetman, David Pinto, João Torre, Alessandra Della |
| dc.subject.por.fl_str_mv |
Ecology, Evolution, Behavior and Systematics Genetics Insect Science Infectious Diseases Immunology SDG 3 - Good Health and Well-being |
| topic |
Ecology, Evolution, Behavior and Systematics Genetics Insect Science Infectious Diseases Immunology SDG 3 - Good Health and Well-being |
| description |
PMID: 26047479 WOS:000355652200031 |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-06-05 2015-06-05T00:00:00Z 2018-05-14T22:02:06Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://doi.org/10.1371/journal.pone.0127804 |
| url |
https://doi.org/10.1371/journal.pone.0127804 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1932-6203 PURE: 1728870 http://www.scopus.com/inward/record.url?scp=84934942312&partnerID=8YFLogxK https://doi.org/10.1371/journal.pone.0127804 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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