Within-host and synaptic transmissions: contributions to the spread of HIV infection

Detalhes bibliográficos
Autor(a) principal: Carvalho, Ana R.M.
Data de Publicação: 2016
Outros Autores: Pinto, Carla M.A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/9282
Resumo: We study the contributions of within-host (virus-to-cell) and synaptic (cell-to-cell) transmissions in a mathematical model for human immunodeficiency virus epidemics. The model also includes drug resistance. We prove the local and global stability of the disease-free equilibrium and the local stability of the endemic equilibrium. We analyse the effect of the cell-to-cell transmission rate on the value of the reproduction number, R0. Moreover, we show evidence of a qualitative change in the models’ dynamics, subjected to the value of the drug efficacy. In the end, important inferences are drawn.
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spelling Within-host and synaptic transmissions: contributions to the spread of HIV infectionHIVSynaptic transmissionWithin-host transmissionTreatmentDrug resistanceWe study the contributions of within-host (virus-to-cell) and synaptic (cell-to-cell) transmissions in a mathematical model for human immunodeficiency virus epidemics. The model also includes drug resistance. We prove the local and global stability of the disease-free equilibrium and the local stability of the endemic equilibrium. We analyse the effect of the cell-to-cell transmission rate on the value of the reproduction number, R0. Moreover, we show evidence of a qualitative change in the models’ dynamics, subjected to the value of the drug efficacy. In the end, important inferences are drawn.WileyRepositório Científico do Instituto Politécnico do PortoCarvalho, Ana R.M.Pinto, Carla M.A.20162116-01-01T00:00:00Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/9282eng10.1002/mma.4047metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:50:34Zoai:recipp.ipp.pt:10400.22/9282Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:29:53.515366Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Within-host and synaptic transmissions: contributions to the spread of HIV infection
title Within-host and synaptic transmissions: contributions to the spread of HIV infection
spellingShingle Within-host and synaptic transmissions: contributions to the spread of HIV infection
Carvalho, Ana R.M.
HIV
Synaptic transmission
Within-host transmission
Treatment
Drug resistance
title_short Within-host and synaptic transmissions: contributions to the spread of HIV infection
title_full Within-host and synaptic transmissions: contributions to the spread of HIV infection
title_fullStr Within-host and synaptic transmissions: contributions to the spread of HIV infection
title_full_unstemmed Within-host and synaptic transmissions: contributions to the spread of HIV infection
title_sort Within-host and synaptic transmissions: contributions to the spread of HIV infection
author Carvalho, Ana R.M.
author_facet Carvalho, Ana R.M.
Pinto, Carla M.A.
author_role author
author2 Pinto, Carla M.A.
author2_role author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Carvalho, Ana R.M.
Pinto, Carla M.A.
dc.subject.por.fl_str_mv HIV
Synaptic transmission
Within-host transmission
Treatment
Drug resistance
topic HIV
Synaptic transmission
Within-host transmission
Treatment
Drug resistance
description We study the contributions of within-host (virus-to-cell) and synaptic (cell-to-cell) transmissions in a mathematical model for human immunodeficiency virus epidemics. The model also includes drug resistance. We prove the local and global stability of the disease-free equilibrium and the local stability of the endemic equilibrium. We analyse the effect of the cell-to-cell transmission rate on the value of the reproduction number, R0. Moreover, we show evidence of a qualitative change in the models’ dynamics, subjected to the value of the drug efficacy. In the end, important inferences are drawn.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2116-01-01T00:00:00Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/9282
url http://hdl.handle.net/10400.22/9282
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1002/mma.4047
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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