Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic

Detalhes bibliográficos
Autor(a) principal: Diógenes, Maria José
Data de Publicação: 2004
Outros Autores: Fernandes, Catarina Cunha, Sebastião, Ana M, Ribeiro, Joaquim A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/7505
Resumo: ©2004 Society for Neuroscience
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spelling Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synapticAdenosine receptorsBrain-derived neurotrophic factor (BDNF)HippocampusSynaptic transmissionNeuromodulationNeurotrophic factors©2004 Society for NeuroscienceBoth brain-derived neurotrophic factor (BDNF) and adenosine influence neuronal plasticity. We now investigated how adenosine influences the action of BDNF on synaptic transmission in the CA1 area of the rat hippocampal slices. Alone, BDNF (20 –100 ng/ml) did not significantly affect field EPSPs (fEPSPs). However, a 2 min pulse of high-K+ (10 mM) 46 min before the application of BDNF (20 ng/ml)triggered an excitatory action, an effect blocked by the TrkB receptor inhibitor K252a (200 nM), by the adenosine A2A receptor antagonist ZM241385 (50 nM), and by the protein kinaseAinhibitor H-89 (1µM). Presynaptic, rather than postsynaptic depolarization was required to trigger the BDNF action because after K+ depolarization BDNF also increased EPSCs recorded from pyramidal neurons voltageclamped at -60 mV, and transient postsynaptic depolarization was unable to unmask the BDNF action. A weak theta burst stimulation of the afferents could elicit potentiation of synaptic transmission only when applied in the presence of BDNF. Activation of adenosineA2A receptors with CGS 21680 (10 nM), or the increase in extracellular adenosine levels induced by 5-iodotubercidin (100 nM) triggered the excitatory action of BDNF, a process prevented by ZM 241385 and by H-89. In the presence of dibutyryl-cAMP (0.5 mM), BDNF also increased fEPSPs but postsynaptic cAMP (0.5mM) was unable to trigger the BDNF action. It is concluded that presynaptic activity-dependent release of adenosine, through activation of A2A receptors, facilitates BDNF modulation of synaptic transmission at hippocampal synapses.This work was supported by Fundação para a Ciência e TecnologiaSociety for NeuroscienceRepositório da Universidade de LisboaDiógenes, Maria JoséFernandes, Catarina CunhaSebastião, Ana MRibeiro, Joaquim A.2013-01-15T15:29:21Z20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/7505engThe Journal of Neuroscience, March 24, 2004 • 24(12):2905–29130270-6474http://dx.doi.org/10.1523/JNEUROSCI.4454-03.2004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T17:10:25Zoai:repositorio.ul.pt:10451/7505Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T17:10:25Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
title Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
spellingShingle Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
Diógenes, Maria José
Adenosine receptors
Brain-derived neurotrophic factor (BDNF)
Hippocampus
Synaptic transmission
Neuromodulation
Neurotrophic factors
title_short Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
title_full Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
title_fullStr Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
title_full_unstemmed Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
title_sort Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic
author Diógenes, Maria José
author_facet Diógenes, Maria José
Fernandes, Catarina Cunha
Sebastião, Ana M
Ribeiro, Joaquim A.
author_role author
author2 Fernandes, Catarina Cunha
Sebastião, Ana M
Ribeiro, Joaquim A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Diógenes, Maria José
Fernandes, Catarina Cunha
Sebastião, Ana M
Ribeiro, Joaquim A.
dc.subject.por.fl_str_mv Adenosine receptors
Brain-derived neurotrophic factor (BDNF)
Hippocampus
Synaptic transmission
Neuromodulation
Neurotrophic factors
topic Adenosine receptors
Brain-derived neurotrophic factor (BDNF)
Hippocampus
Synaptic transmission
Neuromodulation
Neurotrophic factors
description ©2004 Society for Neuroscience
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01T00:00:00Z
2013-01-15T15:29:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/7505
url http://hdl.handle.net/10451/7505
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv The Journal of Neuroscience, March 24, 2004 • 24(12):2905–2913
0270-6474
http://dx.doi.org/10.1523/JNEUROSCI.4454-03.2004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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