Metabolomics of cell lines: a tool for aging research

Detalhes bibliográficos
Autor(a) principal: Rocha, Ana Filipa Seixas Fonte da
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/28961
Resumo: The world is aging and therefore it is essential to understand how the development of this process in organisms is, especially in human beings. Its knowing that this phenomenon does not occur in the same way in all individuals, and that there are some with a chronological age of 80 years and yet, they present a condition of a younger subject. Thus, it is essential to join efforts to understand this event. Currently, there are several models for the study of those process, from animal models, to computational or cellular models, with the latter having more advantages. Cell models, namely cell models of fibroblasts, are thus increasingly used for metabolomics research in the aging research since through these techniques we are able to indirectly study the pathways of this process, since this gives valuable insights into the composition of metabolites present in a sample. An approach that combines several of these tools, such as FTIR, MS or NMR, will be an asset and will allow for the study of aging at a molecular level and possible reveal new discoveries.
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spelling Metabolomics of cell lines: a tool for aging researchAgingAging biomarkersCell cultures for aging studiesFibroblastsFTIRMetabolomicsThe world is aging and therefore it is essential to understand how the development of this process in organisms is, especially in human beings. Its knowing that this phenomenon does not occur in the same way in all individuals, and that there are some with a chronological age of 80 years and yet, they present a condition of a younger subject. Thus, it is essential to join efforts to understand this event. Currently, there are several models for the study of those process, from animal models, to computational or cellular models, with the latter having more advantages. Cell models, namely cell models of fibroblasts, are thus increasingly used for metabolomics research in the aging research since through these techniques we are able to indirectly study the pathways of this process, since this gives valuable insights into the composition of metabolites present in a sample. An approach that combines several of these tools, such as FTIR, MS or NMR, will be an asset and will allow for the study of aging at a molecular level and possible reveal new discoveries.O mundo está a envelhecer e, torna-se fundamental perceber como é o desenvolvimento desse processo nos organismos, principalmente nos seres humanos. É sabido que este fenómeno não ocorre da mesma forma em todos os indivíduos e que existem alguns com idade cronológica de 80 anos e, ainda assim, apresentam uma condição de um indivíduo mais jovem. Assim, é essencial unir esforços para entender este processo. Atualmente, existem vários modelos para o estudo do envelhecimento, desde modelos animais a modelos computacionais ou celulares, sendo que este último apresenta mais vantagens. Modelos celulares, nomeadamente, modelos celulares de fibroblastos são cada vez mais utilizados em metabolómica para a investigação do envelhecimento, pois através destas técnicas é possível estudar indiretamente as vias desse processo, uma vez que fornece informações valiosas sobre a composição dos metabolitos presentes numa amostra. Uma abordagem combinatória dessas ferramentas, como FTIR, MS ou NMR, constitui uma mais valia, permitirá o estudo do envelhecimento a um nível molecular e, possivelmente, revelará novas descobertas.2020-07-29T17:49:47Z2020-07-20T00:00:00Z2020-07-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10773/28961engRocha, Ana Filipa Seixas Fonte dainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:56:01Zoai:ria.ua.pt:10773/28961Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:01:25.236370Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Metabolomics of cell lines: a tool for aging research
title Metabolomics of cell lines: a tool for aging research
spellingShingle Metabolomics of cell lines: a tool for aging research
Rocha, Ana Filipa Seixas Fonte da
Aging
Aging biomarkers
Cell cultures for aging studies
Fibroblasts
FTIR
Metabolomics
title_short Metabolomics of cell lines: a tool for aging research
title_full Metabolomics of cell lines: a tool for aging research
title_fullStr Metabolomics of cell lines: a tool for aging research
title_full_unstemmed Metabolomics of cell lines: a tool for aging research
title_sort Metabolomics of cell lines: a tool for aging research
author Rocha, Ana Filipa Seixas Fonte da
author_facet Rocha, Ana Filipa Seixas Fonte da
author_role author
dc.contributor.author.fl_str_mv Rocha, Ana Filipa Seixas Fonte da
dc.subject.por.fl_str_mv Aging
Aging biomarkers
Cell cultures for aging studies
Fibroblasts
FTIR
Metabolomics
topic Aging
Aging biomarkers
Cell cultures for aging studies
Fibroblasts
FTIR
Metabolomics
description The world is aging and therefore it is essential to understand how the development of this process in organisms is, especially in human beings. Its knowing that this phenomenon does not occur in the same way in all individuals, and that there are some with a chronological age of 80 years and yet, they present a condition of a younger subject. Thus, it is essential to join efforts to understand this event. Currently, there are several models for the study of those process, from animal models, to computational or cellular models, with the latter having more advantages. Cell models, namely cell models of fibroblasts, are thus increasingly used for metabolomics research in the aging research since through these techniques we are able to indirectly study the pathways of this process, since this gives valuable insights into the composition of metabolites present in a sample. An approach that combines several of these tools, such as FTIR, MS or NMR, will be an asset and will allow for the study of aging at a molecular level and possible reveal new discoveries.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-29T17:49:47Z
2020-07-20T00:00:00Z
2020-07-20
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url http://hdl.handle.net/10773/28961
dc.language.iso.fl_str_mv eng
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