Concentration of Fibroblasts in the Vocal Fold of Elderly
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jvoice.2022.10.017 http://hdl.handle.net/11449/247940 |
Resumo: | Objective: To study the concentration of fibroblasts in the vocal folds of elderly people. Material and Methods: The vocal folds of 13 cadavers were removed and divided into two age groups: Control group: n-5, 18-40 years; Elderly group: n-8, ≥75 years). The vocal folds were dissected and prepared for immunohistochemical analysis using the SA100 antibody to fibroblasts. The sites analyzed were maculae flavae and medial (or vibrating) portion of the vocal folds. The AVsoft program was used to count the cells. Results: A higher concentration of fibroblasts was identified in the maculae flavae of the larynx of young adults and in the medial portion of the vocal folds of the elderly. However, these results did not determine statistically significant differences, allowing us to conclude that there was no effect of age on the concentration of fibroblasts in the vocal folds. Conclusion: In the larynx of the elderly, the fibroblast population remains similar to the young adults, both in the maculae flavae and in the body of the vocal folds, possibly being responsible for the constant production of fibrous matrix in the lamina propria. Functional changes in these cells are probably more marked than quantitative ones. |
id |
UNSP_0cb578114492787e09a30ce11ffafc43 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/247940 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Concentration of Fibroblasts in the Vocal Fold of ElderlyAging voiceFibroblastsImmunohistchemicalPresbyphoniaObjective: To study the concentration of fibroblasts in the vocal folds of elderly people. Material and Methods: The vocal folds of 13 cadavers were removed and divided into two age groups: Control group: n-5, 18-40 years; Elderly group: n-8, ≥75 years). The vocal folds were dissected and prepared for immunohistochemical analysis using the SA100 antibody to fibroblasts. The sites analyzed were maculae flavae and medial (or vibrating) portion of the vocal folds. The AVsoft program was used to count the cells. Results: A higher concentration of fibroblasts was identified in the maculae flavae of the larynx of young adults and in the medial portion of the vocal folds of the elderly. However, these results did not determine statistically significant differences, allowing us to conclude that there was no effect of age on the concentration of fibroblasts in the vocal folds. Conclusion: In the larynx of the elderly, the fibroblast population remains similar to the young adults, both in the maculae flavae and in the body of the vocal folds, possibly being responsible for the constant production of fibrous matrix in the lamina propria. Functional changes in these cells are probably more marked than quantitative ones.Botucatu Medical School UnespSpeech Pathologist. Botucatu Medical School Unesp BotucatuBiostatistician. Department of Biostatistics Biosciences Institute Unesp BotucatuBiosciences Institute Unesp BotucatuHead and Neck Surgery Department Botucatu Medical School UnespBotucatu Medical School UnespSpeech Pathologist. Botucatu Medical School Unesp BotucatuBiostatistician. Department of Biostatistics Biosciences Institute Unesp BotucatuBiosciences Institute Unesp BotucatuHead and Neck Surgery Department Botucatu Medical School UnespUniversidade Estadual Paulista (UNESP)Carneiro, Neemias S. [UNESP]Pessin, Adriana B.B. [UNESP]Rodrigues, Sergio A. [UNESP]Pellizon, Claudia H. [UNESP]Xavier, Claudia M. [UNESP]Martins, Regina H.G. [UNESP]2023-07-29T13:30:06Z2023-07-29T13:30:06Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jvoice.2022.10.017Journal of Voice.1873-45880892-1997http://hdl.handle.net/11449/24794010.1016/j.jvoice.2022.10.0172-s2.0-85142515270Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Voiceinfo:eu-repo/semantics/openAccess2023-07-29T13:30:06Zoai:repositorio.unesp.br:11449/247940Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:30:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Concentration of Fibroblasts in the Vocal Fold of Elderly |
title |
Concentration of Fibroblasts in the Vocal Fold of Elderly |
spellingShingle |
Concentration of Fibroblasts in the Vocal Fold of Elderly Carneiro, Neemias S. [UNESP] Aging voice Fibroblasts Immunohistchemical Presbyphonia |
title_short |
Concentration of Fibroblasts in the Vocal Fold of Elderly |
title_full |
Concentration of Fibroblasts in the Vocal Fold of Elderly |
title_fullStr |
Concentration of Fibroblasts in the Vocal Fold of Elderly |
title_full_unstemmed |
Concentration of Fibroblasts in the Vocal Fold of Elderly |
title_sort |
Concentration of Fibroblasts in the Vocal Fold of Elderly |
author |
Carneiro, Neemias S. [UNESP] |
author_facet |
Carneiro, Neemias S. [UNESP] Pessin, Adriana B.B. [UNESP] Rodrigues, Sergio A. [UNESP] Pellizon, Claudia H. [UNESP] Xavier, Claudia M. [UNESP] Martins, Regina H.G. [UNESP] |
author_role |
author |
author2 |
Pessin, Adriana B.B. [UNESP] Rodrigues, Sergio A. [UNESP] Pellizon, Claudia H. [UNESP] Xavier, Claudia M. [UNESP] Martins, Regina H.G. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Carneiro, Neemias S. [UNESP] Pessin, Adriana B.B. [UNESP] Rodrigues, Sergio A. [UNESP] Pellizon, Claudia H. [UNESP] Xavier, Claudia M. [UNESP] Martins, Regina H.G. [UNESP] |
dc.subject.por.fl_str_mv |
Aging voice Fibroblasts Immunohistchemical Presbyphonia |
topic |
Aging voice Fibroblasts Immunohistchemical Presbyphonia |
description |
Objective: To study the concentration of fibroblasts in the vocal folds of elderly people. Material and Methods: The vocal folds of 13 cadavers were removed and divided into two age groups: Control group: n-5, 18-40 years; Elderly group: n-8, ≥75 years). The vocal folds were dissected and prepared for immunohistochemical analysis using the SA100 antibody to fibroblasts. The sites analyzed were maculae flavae and medial (or vibrating) portion of the vocal folds. The AVsoft program was used to count the cells. Results: A higher concentration of fibroblasts was identified in the maculae flavae of the larynx of young adults and in the medial portion of the vocal folds of the elderly. However, these results did not determine statistically significant differences, allowing us to conclude that there was no effect of age on the concentration of fibroblasts in the vocal folds. Conclusion: In the larynx of the elderly, the fibroblast population remains similar to the young adults, both in the maculae flavae and in the body of the vocal folds, possibly being responsible for the constant production of fibrous matrix in the lamina propria. Functional changes in these cells are probably more marked than quantitative ones. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:30:06Z 2023-07-29T13:30:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jvoice.2022.10.017 Journal of Voice. 1873-4588 0892-1997 http://hdl.handle.net/11449/247940 10.1016/j.jvoice.2022.10.017 2-s2.0-85142515270 |
url |
http://dx.doi.org/10.1016/j.jvoice.2022.10.017 http://hdl.handle.net/11449/247940 |
identifier_str_mv |
Journal of Voice. 1873-4588 0892-1997 10.1016/j.jvoice.2022.10.017 2-s2.0-85142515270 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Voice |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965406909169664 |