Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors

Detalhes bibliográficos
Autor(a) principal: Ørnbjerg, Lykke M.
Data de Publicação: 2022
Outros Autores: Linde, Louise, Georgiadis, Stylianos, Rasmussen, Simon H., Lindström, Ulf, Askling, Johan, Michelsen, Brigitte, Giuseppe, Daniela Di, Wallman, Johan K., Pavelka, Karel, Závada, Jakub, Nissen, Michael J., Jones, Gareth T., Relas, Heikki, Pirilä, Laura, Tomšič, Matija, Rotar, Ziga, Geirsson, Arni Jon, Gudbjornsson, Bjorn, Kristianslund, Eirik K., van sder Horst-Bruinsma, Irene, Loft, Anne Gitte, Laas, Karin, Iannone, Florenzo, Corrado, Addolorata, Ciurea, Adrian, Santos, Maria J., Santos, Helena, Codreanu, Catalin, Akkoc, Nurullah, Gunduz, Ozgul S., Glintborg, Bente, Østergaard, Mikkel, Hetland, Merete Lund
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/143581
Resumo: Funding Information: LMØ, LL, SG and SHR: research grants from Novartis; UL: none; DDG none; JKW: consultant of AbbVie, Amgen, Celgene, Eli Lilly and Novartis; BG: research grants from Pfizer, Abbvie and BMS; LP: consultant of Novartis Finland, UCB Pharma, Pfizer, Sanofi, BMS, AbbVie, Amgen, Celgene, Eli Lilly, Boehringer-Ingelheim, Mylan; KL: consulting and/or speaking fees from Amgen, Johnson and Johnson and Novartis; ACo: research grants, consulting and/or speaking fees from Amgen, Lilly, Pfizer, Boehringer Ingelheim; KP: speaker and consulting fees from Pfizer, MSD, BMS, UCB, Amgen, Egis, Roche, AbbVie; JZ: speaker and consulting fees from Abbvie, Elli-Lilly, Sandoz, Novartis, Egis, UCB; EKK: none; NA: speaking fees from Pfizer; ÖSG: none; HS: research grant from Sociedade Portuguesa de Reumatologia and speaker and/or consultancy fees from Abbvie, Janssen, Lilly, Novartis and Pfizer; MJN: consulting and/or speaking fees from AbbVie, Eli Lilly, Janssens, Novartis and Pfizer; BM: research grant from Novartis; GTJ: research grants from AbbVie, Pfizer, UCB, Amgen, GSK. Speaker fee from Janssen; HR: consulting and/or speaking fees from Abbvie, Celgene, Pfizer, UCB, and Viatris; MT: consulting and/or speaking fees from Abbvie, Amgen, Biogen, Eli Lilly, Janssen, Medis, MSD, Novartis, Pfizer, Sanofi, Sandoz-Lek; AJG: none; IHB: Consultant for Abbvie, UCB, MSD, Novartis, Lilly, unrestricted Grants received for investigator initiated studies from: MSD, Pfizer, AbbVie, UCB, fees received for Lectures from BMS, AbbVie, Pfizer, MSD ; JA: PI for agreements between Karolinska Institutet and Abbvie, Astra-Zeneca, BMS, Eli Lilly, Janssen, MSD, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB; FI: consulting and/or speaking from Abbvie, Amgen, AstraZeneca, BMS, Galapagos, Janssen, Lilly, MSD, Novartis, Pfizer, Roche and UCB; AGL: Research Grant from Novartis, and speaker and/or consultancy fees from AbbVie, Janssen, Lilly, MSD, Novartis, Pfizer, Roche, and UCB; ACi: consulting and/or speaking fees from AbbVie, Eli Lilly, Merck Sharp & Dohme, Novartis and Pfizer; MJS: speaker fees from Abbvie, AstraZeneca, Lilly, Novartis and Pfizer; CC: Speaker and consultancy fees from AbbVie, Amgen, Boehringer Ingelheim, Ewopharma, Lilly, Novartis, Pfizer; ZR: speaker or consultancy fees from Abbvie, Novartis, MSD, Medis, Biogen, Eli Lilly, Pfizer, Sanofi, Lek, Janssen; BjG: consulting and/or speaking fees from Amgen and Novartis; MØ: research grants from Abbvie, BMS, Merck, Celgene and Novartis, and speaker and/or consultancy fees from Abbvie, BMS, Boehringer-Ingelheim, Celgene, Eli-Lilly, Hospira, Janssen, Merck, Novartis, Novo, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi and UCB; MLH: Research grants from Abbvie, Biogen, BMS, Celltrion, Eli Lilly, Janssen Biologics B.V, Lundbeck Fonden, MSD, Medac, Pfizer, Roche, Samsung Biopies, Sandoz, Novartis. Funding Information: This work was supported by Novartis Pharma AG . Publisher Copyright: © 2022
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spelling Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitorsData from the EuroSpA collaborationAnkylosing spondylitis disease activity scoreAxial spondyloarthritisPredictorsTNF-inhibitorsRheumatologyAnesthesiology and Pain MedicineFunding Information: LMØ, LL, SG and SHR: research grants from Novartis; UL: none; DDG none; JKW: consultant of AbbVie, Amgen, Celgene, Eli Lilly and Novartis; BG: research grants from Pfizer, Abbvie and BMS; LP: consultant of Novartis Finland, UCB Pharma, Pfizer, Sanofi, BMS, AbbVie, Amgen, Celgene, Eli Lilly, Boehringer-Ingelheim, Mylan; KL: consulting and/or speaking fees from Amgen, Johnson and Johnson and Novartis; ACo: research grants, consulting and/or speaking fees from Amgen, Lilly, Pfizer, Boehringer Ingelheim; KP: speaker and consulting fees from Pfizer, MSD, BMS, UCB, Amgen, Egis, Roche, AbbVie; JZ: speaker and consulting fees from Abbvie, Elli-Lilly, Sandoz, Novartis, Egis, UCB; EKK: none; NA: speaking fees from Pfizer; ÖSG: none; HS: research grant from Sociedade Portuguesa de Reumatologia and speaker and/or consultancy fees from Abbvie, Janssen, Lilly, Novartis and Pfizer; MJN: consulting and/or speaking fees from AbbVie, Eli Lilly, Janssens, Novartis and Pfizer; BM: research grant from Novartis; GTJ: research grants from AbbVie, Pfizer, UCB, Amgen, GSK. Speaker fee from Janssen; HR: consulting and/or speaking fees from Abbvie, Celgene, Pfizer, UCB, and Viatris; MT: consulting and/or speaking fees from Abbvie, Amgen, Biogen, Eli Lilly, Janssen, Medis, MSD, Novartis, Pfizer, Sanofi, Sandoz-Lek; AJG: none; IHB: Consultant for Abbvie, UCB, MSD, Novartis, Lilly, unrestricted Grants received for investigator initiated studies from: MSD, Pfizer, AbbVie, UCB, fees received for Lectures from BMS, AbbVie, Pfizer, MSD ; JA: PI for agreements between Karolinska Institutet and Abbvie, Astra-Zeneca, BMS, Eli Lilly, Janssen, MSD, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB; FI: consulting and/or speaking from Abbvie, Amgen, AstraZeneca, BMS, Galapagos, Janssen, Lilly, MSD, Novartis, Pfizer, Roche and UCB; AGL: Research Grant from Novartis, and speaker and/or consultancy fees from AbbVie, Janssen, Lilly, MSD, Novartis, Pfizer, Roche, and UCB; ACi: consulting and/or speaking fees from AbbVie, Eli Lilly, Merck Sharp & Dohme, Novartis and Pfizer; MJS: speaker fees from Abbvie, AstraZeneca, Lilly, Novartis and Pfizer; CC: Speaker and consultancy fees from AbbVie, Amgen, Boehringer Ingelheim, Ewopharma, Lilly, Novartis, Pfizer; ZR: speaker or consultancy fees from Abbvie, Novartis, MSD, Medis, Biogen, Eli Lilly, Pfizer, Sanofi, Lek, Janssen; BjG: consulting and/or speaking fees from Amgen and Novartis; MØ: research grants from Abbvie, BMS, Merck, Celgene and Novartis, and speaker and/or consultancy fees from Abbvie, BMS, Boehringer-Ingelheim, Celgene, Eli-Lilly, Hospira, Janssen, Merck, Novartis, Novo, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi and UCB; MLH: Research grants from Abbvie, Biogen, BMS, Celltrion, Eli Lilly, Janssen Biologics B.V, Lundbeck Fonden, MSD, Medac, Pfizer, Roche, Samsung Biopies, Sandoz, Novartis. Funding Information: This work was supported by Novartis Pharma AG . Publisher Copyright: © 2022Objectives: In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries. Methods: Baseline demographic and clinical characteristics were collected. Outcomes were investigated per registry and in pooled data using logistic regression analyses on multiply imputed data. Results: The consistency of baseline predictors in individual registries justified pooling the data. In the pooled dataset (n = 21,196), the 6-month rates for ASDAS inactive disease and ASDAS CII were 26% and 51%, and the 12-month drug retention rate 65% in patients with available data (n = 9,845, n = 6,948 and n = 21,196, respectively). Nine common baseline predictors of ASDAS inactive disease, ASDAS CII and 12-month drug retention were identified, and the odds ratios (95%-confidence interval) for ASDAS inactive disease were: age, per year: 0.97 (0.97–0.98), men vs. women: 1.88 (1.60–2.22), current vs. non-smoking: 0.76 (0.63–0.91), HLA-B27 positive vs. negative: 1.51 (1.20–1.91), TNF start year 2015–2018 vs. 2009–2014: 1.24 (1.06–1.45), CRP>10 vs. ≤10 mg/l: 1.49 (1.25–1.77), one unit increase in health assessment questionnaire (HAQ): 0.77 (0.58–1.03), one-millimeter (mm) increase in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) fatigue and spinal pain: 0.99 (0.99–1.00) and 0.99 (0.99–1.99), respectively Conclusion: Common baseline predictors of treatment response and adherence to TNFi could be identified across data from 15 European registries, indicating that they may be universal across different axSpA populations.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNØrnbjerg, Lykke M.Linde, LouiseGeorgiadis, StylianosRasmussen, Simon H.Lindström, UlfAskling, JohanMichelsen, BrigitteGiuseppe, Daniela DiWallman, Johan K.Pavelka, KarelZávada, JakubNissen, Michael J.Jones, Gareth T.Relas, HeikkiPirilä, LauraTomšič, MatijaRotar, ZigaGeirsson, Arni JonGudbjornsson, BjornKristianslund, Eirik K.van sder Horst-Bruinsma, IreneLoft, Anne GitteLaas, KarinIannone, FlorenzoCorrado, AddolorataCiurea, AdrianSantos, Maria J.Santos, HelenaCodreanu, CatalinAkkoc, NurullahGunduz, Ozgul S.Glintborg, BenteØstergaard, MikkelHetland, Merete Lund2022-09-07T23:14:48Z2022-102022-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143581eng0049-0172PURE: 46203886https://doi.org/10.1016/j.semarthrit.2022.152081info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:04:57Zoai:run.unl.pt:10362/143581Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:04:57Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
Data from the EuroSpA collaboration
title Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
spellingShingle Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
Ørnbjerg, Lykke M.
Ankylosing spondylitis disease activity score
Axial spondyloarthritis
Predictors
TNF-inhibitors
Rheumatology
Anesthesiology and Pain Medicine
title_short Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
title_full Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
title_fullStr Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
title_full_unstemmed Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
title_sort Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors
author Ørnbjerg, Lykke M.
author_facet Ørnbjerg, Lykke M.
Linde, Louise
Georgiadis, Stylianos
Rasmussen, Simon H.
Lindström, Ulf
Askling, Johan
Michelsen, Brigitte
Giuseppe, Daniela Di
Wallman, Johan K.
Pavelka, Karel
Závada, Jakub
Nissen, Michael J.
Jones, Gareth T.
Relas, Heikki
Pirilä, Laura
Tomšič, Matija
Rotar, Ziga
Geirsson, Arni Jon
Gudbjornsson, Bjorn
Kristianslund, Eirik K.
van sder Horst-Bruinsma, Irene
Loft, Anne Gitte
Laas, Karin
Iannone, Florenzo
Corrado, Addolorata
Ciurea, Adrian
Santos, Maria J.
Santos, Helena
Codreanu, Catalin
Akkoc, Nurullah
Gunduz, Ozgul S.
Glintborg, Bente
Østergaard, Mikkel
Hetland, Merete Lund
author_role author
author2 Linde, Louise
Georgiadis, Stylianos
Rasmussen, Simon H.
Lindström, Ulf
Askling, Johan
Michelsen, Brigitte
Giuseppe, Daniela Di
Wallman, Johan K.
Pavelka, Karel
Závada, Jakub
Nissen, Michael J.
Jones, Gareth T.
Relas, Heikki
Pirilä, Laura
Tomšič, Matija
Rotar, Ziga
Geirsson, Arni Jon
Gudbjornsson, Bjorn
Kristianslund, Eirik K.
van sder Horst-Bruinsma, Irene
Loft, Anne Gitte
Laas, Karin
Iannone, Florenzo
Corrado, Addolorata
Ciurea, Adrian
Santos, Maria J.
Santos, Helena
Codreanu, Catalin
Akkoc, Nurullah
Gunduz, Ozgul S.
Glintborg, Bente
Østergaard, Mikkel
Hetland, Merete Lund
author2_role author
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dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Ørnbjerg, Lykke M.
Linde, Louise
Georgiadis, Stylianos
Rasmussen, Simon H.
Lindström, Ulf
Askling, Johan
Michelsen, Brigitte
Giuseppe, Daniela Di
Wallman, Johan K.
Pavelka, Karel
Závada, Jakub
Nissen, Michael J.
Jones, Gareth T.
Relas, Heikki
Pirilä, Laura
Tomšič, Matija
Rotar, Ziga
Geirsson, Arni Jon
Gudbjornsson, Bjorn
Kristianslund, Eirik K.
van sder Horst-Bruinsma, Irene
Loft, Anne Gitte
Laas, Karin
Iannone, Florenzo
Corrado, Addolorata
Ciurea, Adrian
Santos, Maria J.
Santos, Helena
Codreanu, Catalin
Akkoc, Nurullah
Gunduz, Ozgul S.
Glintborg, Bente
Østergaard, Mikkel
Hetland, Merete Lund
dc.subject.por.fl_str_mv Ankylosing spondylitis disease activity score
Axial spondyloarthritis
Predictors
TNF-inhibitors
Rheumatology
Anesthesiology and Pain Medicine
topic Ankylosing spondylitis disease activity score
Axial spondyloarthritis
Predictors
TNF-inhibitors
Rheumatology
Anesthesiology and Pain Medicine
description Funding Information: LMØ, LL, SG and SHR: research grants from Novartis; UL: none; DDG none; JKW: consultant of AbbVie, Amgen, Celgene, Eli Lilly and Novartis; BG: research grants from Pfizer, Abbvie and BMS; LP: consultant of Novartis Finland, UCB Pharma, Pfizer, Sanofi, BMS, AbbVie, Amgen, Celgene, Eli Lilly, Boehringer-Ingelheim, Mylan; KL: consulting and/or speaking fees from Amgen, Johnson and Johnson and Novartis; ACo: research grants, consulting and/or speaking fees from Amgen, Lilly, Pfizer, Boehringer Ingelheim; KP: speaker and consulting fees from Pfizer, MSD, BMS, UCB, Amgen, Egis, Roche, AbbVie; JZ: speaker and consulting fees from Abbvie, Elli-Lilly, Sandoz, Novartis, Egis, UCB; EKK: none; NA: speaking fees from Pfizer; ÖSG: none; HS: research grant from Sociedade Portuguesa de Reumatologia and speaker and/or consultancy fees from Abbvie, Janssen, Lilly, Novartis and Pfizer; MJN: consulting and/or speaking fees from AbbVie, Eli Lilly, Janssens, Novartis and Pfizer; BM: research grant from Novartis; GTJ: research grants from AbbVie, Pfizer, UCB, Amgen, GSK. Speaker fee from Janssen; HR: consulting and/or speaking fees from Abbvie, Celgene, Pfizer, UCB, and Viatris; MT: consulting and/or speaking fees from Abbvie, Amgen, Biogen, Eli Lilly, Janssen, Medis, MSD, Novartis, Pfizer, Sanofi, Sandoz-Lek; AJG: none; IHB: Consultant for Abbvie, UCB, MSD, Novartis, Lilly, unrestricted Grants received for investigator initiated studies from: MSD, Pfizer, AbbVie, UCB, fees received for Lectures from BMS, AbbVie, Pfizer, MSD ; JA: PI for agreements between Karolinska Institutet and Abbvie, Astra-Zeneca, BMS, Eli Lilly, Janssen, MSD, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB; FI: consulting and/or speaking from Abbvie, Amgen, AstraZeneca, BMS, Galapagos, Janssen, Lilly, MSD, Novartis, Pfizer, Roche and UCB; AGL: Research Grant from Novartis, and speaker and/or consultancy fees from AbbVie, Janssen, Lilly, MSD, Novartis, Pfizer, Roche, and UCB; ACi: consulting and/or speaking fees from AbbVie, Eli Lilly, Merck Sharp & Dohme, Novartis and Pfizer; MJS: speaker fees from Abbvie, AstraZeneca, Lilly, Novartis and Pfizer; CC: Speaker and consultancy fees from AbbVie, Amgen, Boehringer Ingelheim, Ewopharma, Lilly, Novartis, Pfizer; ZR: speaker or consultancy fees from Abbvie, Novartis, MSD, Medis, Biogen, Eli Lilly, Pfizer, Sanofi, Lek, Janssen; BjG: consulting and/or speaking fees from Amgen and Novartis; MØ: research grants from Abbvie, BMS, Merck, Celgene and Novartis, and speaker and/or consultancy fees from Abbvie, BMS, Boehringer-Ingelheim, Celgene, Eli-Lilly, Hospira, Janssen, Merck, Novartis, Novo, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi and UCB; MLH: Research grants from Abbvie, Biogen, BMS, Celltrion, Eli Lilly, Janssen Biologics B.V, Lundbeck Fonden, MSD, Medac, Pfizer, Roche, Samsung Biopies, Sandoz, Novartis. Funding Information: This work was supported by Novartis Pharma AG . Publisher Copyright: © 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-09-07T23:14:48Z
2022-10
2022-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/143581
url http://hdl.handle.net/10362/143581
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0049-0172
PURE: 46203886
https://doi.org/10.1016/j.semarthrit.2022.152081
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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