Association of body mass index with Juvenile Idiopathic Arthritis disease activity
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/116088 |
Resumo: | OBJECTIVE: To investigate the relationship between body mass index (BMI) and disease activity in patients with Juvenile Idiopathic Arthritis (JIA). METHODS: Patients with JIA, aged ≤18 years, registered at the Rheumatic Diseases Portuguese Register (Reuma.pt) in Portugal and Brazil were included. Age- and sex-specific BMI percentiles were calculated based on WHO growth standard charts and categorized into underweight (P <3), normal weight (3≤P≤85), overweight (85 <P ≤97) and obesity (P >97). Disease activity was assessed by Juvenile Arthritis Disease Activity Score (JADAS-27). Uni- and multivariate analyses were performed. RESULTS: A total of 275 patients were included. The prevalence of underweight, normal weight, overweight and obesity was 6.9%, 67.3%, 15.3% and 10.5%, respectively. Underweight patients had significantly higher number of active joints (p <0.001), patient's/parent's global assessment of disease activity (PGA) (p=0.020), physician's global assessment of disease activity (PhGA) (p <0.001), erythrocyte sedimentation rate (ESR) (p=0.032) and overall higher JADAS-27 (p <0.001), compared to patients with normal weight, overweight and obesity. In the multivariate regression, underweight persisted significantly associated with higher disease activity, compared to normal weight (B=-9.430, p <0.001), overweight (B=-9.295, p=0.001) and obesity (B=-9.120, p=0.001), when adjusted for age, gender, country, ethnicity, JIA category and therapies used. The diagnosis of RF- (B=3.653, p=0.006) or RF+ polyarticular JIA (B=5.287, p=0.024), the absence of DMARD therapy (B=5.542, p <0.001) and the use of oral GC (B=4.984, p=0.002) were also associated with higher JADAS-27. CONCLUSION: We found an independent association between underweight and higher disease activity in patients with JIA. Further studies are needed to understand the underlying mechanisms of this association. |
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Association of body mass index with Juvenile Idiopathic Arthritis disease activitya Portuguese and Brazilian collaborative analysisJuvenile idiopathic arthritisBody mass indexRheumatologySDG 3 - Good Health and Well-beingOBJECTIVE: To investigate the relationship between body mass index (BMI) and disease activity in patients with Juvenile Idiopathic Arthritis (JIA). METHODS: Patients with JIA, aged ≤18 years, registered at the Rheumatic Diseases Portuguese Register (Reuma.pt) in Portugal and Brazil were included. Age- and sex-specific BMI percentiles were calculated based on WHO growth standard charts and categorized into underweight (P <3), normal weight (3≤P≤85), overweight (85 <P ≤97) and obesity (P >97). Disease activity was assessed by Juvenile Arthritis Disease Activity Score (JADAS-27). Uni- and multivariate analyses were performed. RESULTS: A total of 275 patients were included. The prevalence of underweight, normal weight, overweight and obesity was 6.9%, 67.3%, 15.3% and 10.5%, respectively. Underweight patients had significantly higher number of active joints (p <0.001), patient's/parent's global assessment of disease activity (PGA) (p=0.020), physician's global assessment of disease activity (PhGA) (p <0.001), erythrocyte sedimentation rate (ESR) (p=0.032) and overall higher JADAS-27 (p <0.001), compared to patients with normal weight, overweight and obesity. In the multivariate regression, underweight persisted significantly associated with higher disease activity, compared to normal weight (B=-9.430, p <0.001), overweight (B=-9.295, p=0.001) and obesity (B=-9.120, p=0.001), when adjusted for age, gender, country, ethnicity, JIA category and therapies used. The diagnosis of RF- (B=3.653, p=0.006) or RF+ polyarticular JIA (B=5.287, p=0.024), the absence of DMARD therapy (B=5.542, p <0.001) and the use of oral GC (B=4.984, p=0.002) were also associated with higher JADAS-27. CONCLUSION: We found an independent association between underweight and higher disease activity in patients with JIA. Further studies are needed to understand the underlying mechanisms of this association.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNNeto, AgnaMourão, Ana FilipaOliveira-Ramos, FilipaCampanilho-Marques, RaquelEstanqueiro, PaulaSalgado, ManuelGuedes, MargaridaPiotto, DanielaEmi Aikawa, NadiaMelo Gomes, JoséCabral, MartaConde, MartaFigueira, RicardoSantos, Maria JoséFonseca, João EuricoTerreri, Maria TeresaCanhão, Helena2021-04-23T22:57:21Z2021-01-012021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/116088eng0303-464XPURE: 29237137info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:58:38Zoai:run.unl.pt:10362/116088Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:58.767029Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity a Portuguese and Brazilian collaborative analysis |
title |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity |
spellingShingle |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity Neto, Agna Juvenile idiopathic arthritis Body mass index Rheumatology SDG 3 - Good Health and Well-being |
title_short |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity |
title_full |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity |
title_fullStr |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity |
title_full_unstemmed |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity |
title_sort |
Association of body mass index with Juvenile Idiopathic Arthritis disease activity |
author |
Neto, Agna |
author_facet |
Neto, Agna Mourão, Ana Filipa Oliveira-Ramos, Filipa Campanilho-Marques, Raquel Estanqueiro, Paula Salgado, Manuel Guedes, Margarida Piotto, Daniela Emi Aikawa, Nadia Melo Gomes, José Cabral, Marta Conde, Marta Figueira, Ricardo Santos, Maria José Fonseca, João Eurico Terreri, Maria Teresa Canhão, Helena |
author_role |
author |
author2 |
Mourão, Ana Filipa Oliveira-Ramos, Filipa Campanilho-Marques, Raquel Estanqueiro, Paula Salgado, Manuel Guedes, Margarida Piotto, Daniela Emi Aikawa, Nadia Melo Gomes, José Cabral, Marta Conde, Marta Figueira, Ricardo Santos, Maria José Fonseca, João Eurico Terreri, Maria Teresa Canhão, Helena |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
dc.contributor.author.fl_str_mv |
Neto, Agna Mourão, Ana Filipa Oliveira-Ramos, Filipa Campanilho-Marques, Raquel Estanqueiro, Paula Salgado, Manuel Guedes, Margarida Piotto, Daniela Emi Aikawa, Nadia Melo Gomes, José Cabral, Marta Conde, Marta Figueira, Ricardo Santos, Maria José Fonseca, João Eurico Terreri, Maria Teresa Canhão, Helena |
dc.subject.por.fl_str_mv |
Juvenile idiopathic arthritis Body mass index Rheumatology SDG 3 - Good Health and Well-being |
topic |
Juvenile idiopathic arthritis Body mass index Rheumatology SDG 3 - Good Health and Well-being |
description |
OBJECTIVE: To investigate the relationship between body mass index (BMI) and disease activity in patients with Juvenile Idiopathic Arthritis (JIA). METHODS: Patients with JIA, aged ≤18 years, registered at the Rheumatic Diseases Portuguese Register (Reuma.pt) in Portugal and Brazil were included. Age- and sex-specific BMI percentiles were calculated based on WHO growth standard charts and categorized into underweight (P <3), normal weight (3≤P≤85), overweight (85 <P ≤97) and obesity (P >97). Disease activity was assessed by Juvenile Arthritis Disease Activity Score (JADAS-27). Uni- and multivariate analyses were performed. RESULTS: A total of 275 patients were included. The prevalence of underweight, normal weight, overweight and obesity was 6.9%, 67.3%, 15.3% and 10.5%, respectively. Underweight patients had significantly higher number of active joints (p <0.001), patient's/parent's global assessment of disease activity (PGA) (p=0.020), physician's global assessment of disease activity (PhGA) (p <0.001), erythrocyte sedimentation rate (ESR) (p=0.032) and overall higher JADAS-27 (p <0.001), compared to patients with normal weight, overweight and obesity. In the multivariate regression, underweight persisted significantly associated with higher disease activity, compared to normal weight (B=-9.430, p <0.001), overweight (B=-9.295, p=0.001) and obesity (B=-9.120, p=0.001), when adjusted for age, gender, country, ethnicity, JIA category and therapies used. The diagnosis of RF- (B=3.653, p=0.006) or RF+ polyarticular JIA (B=5.287, p=0.024), the absence of DMARD therapy (B=5.542, p <0.001) and the use of oral GC (B=4.984, p=0.002) were also associated with higher JADAS-27. CONCLUSION: We found an independent association between underweight and higher disease activity in patients with JIA. Further studies are needed to understand the underlying mechanisms of this association. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-23T22:57:21Z 2021-01-01 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/116088 |
url |
http://hdl.handle.net/10362/116088 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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0303-464X PURE: 29237137 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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8 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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