In vitro induction of melanin synthesis and extrusion by tamoxifen

Detalhes bibliográficos
Autor(a) principal: Matamá, Maria Teresa
Data de Publicação: 2013
Outros Autores: Araújo, Rita, Preto, Ana, Paulo, Artur Cavaco, Gomes, A. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/24554
Resumo: Physical appearance has significant importance psychologically and socially, with skin and hair being of prime relevance. Effective ingredients that modulate melanin synthesis are of growing interest. Tamoxifen, a widely used selective oestrogen receptor modulator, SERM, was described occasionally in medical case reports as causing grey hair repigmentation. This work aimed to study, in vitro, the effect of tamoxifen and 4-hydroxy-tamoxifen, one of its most bioactive derivatives, on melanin production in human melanocytes.
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spelling In vitro induction of melanin synthesis and extrusion by tamoxifenCatalaseCell cultureSkin pigmentationSERMGenetic analysisColour cosmeticsScience & TechnologyPhysical appearance has significant importance psychologically and socially, with skin and hair being of prime relevance. Effective ingredients that modulate melanin synthesis are of growing interest. Tamoxifen, a widely used selective oestrogen receptor modulator, SERM, was described occasionally in medical case reports as causing grey hair repigmentation. This work aimed to study, in vitro, the effect of tamoxifen and 4-hydroxy-tamoxifen, one of its most bioactive derivatives, on melanin production in human melanocytes.Teresa Matam a holds a grant from FCT–Fundação para a Ciência e a Tecnologia (SFRH/BPD/47555/2008). This work was supported by FEDER through POFC–COMPETE and by national funds from FCT through the project PEst-C/BIA/UI4050/2011.WileyUniversidade do MinhoMatamá, Maria TeresaAraújo, RitaPreto, AnaPaulo, Artur CavacoGomes, A. C.2013-052013-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24554eng0142-546310.1111/ics.1205223574448http://dx.doi.org/10.1111/ics.12052info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:46:20Zoai:repositorium.sdum.uminho.pt:1822/24554Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:44:19.060918Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro induction of melanin synthesis and extrusion by tamoxifen
title In vitro induction of melanin synthesis and extrusion by tamoxifen
spellingShingle In vitro induction of melanin synthesis and extrusion by tamoxifen
Matamá, Maria Teresa
Catalase
Cell culture
Skin pigmentation
SERM
Genetic analysis
Colour cosmetics
Science & Technology
title_short In vitro induction of melanin synthesis and extrusion by tamoxifen
title_full In vitro induction of melanin synthesis and extrusion by tamoxifen
title_fullStr In vitro induction of melanin synthesis and extrusion by tamoxifen
title_full_unstemmed In vitro induction of melanin synthesis and extrusion by tamoxifen
title_sort In vitro induction of melanin synthesis and extrusion by tamoxifen
author Matamá, Maria Teresa
author_facet Matamá, Maria Teresa
Araújo, Rita
Preto, Ana
Paulo, Artur Cavaco
Gomes, A. C.
author_role author
author2 Araújo, Rita
Preto, Ana
Paulo, Artur Cavaco
Gomes, A. C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Matamá, Maria Teresa
Araújo, Rita
Preto, Ana
Paulo, Artur Cavaco
Gomes, A. C.
dc.subject.por.fl_str_mv Catalase
Cell culture
Skin pigmentation
SERM
Genetic analysis
Colour cosmetics
Science & Technology
topic Catalase
Cell culture
Skin pigmentation
SERM
Genetic analysis
Colour cosmetics
Science & Technology
description Physical appearance has significant importance psychologically and socially, with skin and hair being of prime relevance. Effective ingredients that modulate melanin synthesis are of growing interest. Tamoxifen, a widely used selective oestrogen receptor modulator, SERM, was described occasionally in medical case reports as causing grey hair repigmentation. This work aimed to study, in vitro, the effect of tamoxifen and 4-hydroxy-tamoxifen, one of its most bioactive derivatives, on melanin production in human melanocytes.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
2013-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/24554
url http://hdl.handle.net/1822/24554
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0142-5463
10.1111/ics.12052
23574448
http://dx.doi.org/10.1111/ics.12052
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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