Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/4627 |
Resumo: | In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic. |
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Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applicationsPolymeric scaffoldPolyelectrolyte complexesCytotoxicityOsteoblastsIn this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic.ElsevieruBibliorumCoimbra, PatríciaFerreira, PaulaSousa, Hermínio C. deBatista, Patrícia Sofia PinhançosRodrigues, MiguelCorreia, Ilídio Joaquim SobreiraGil, Maria2018-03-19T10:37:36Z2010-10-162010-10-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4627engCoimbra, P., Ferreira, P., Sousa, H.C., Batista, P., Rodrigues, M.A., Correia, I.J. e Gil, M. H. (2011) “Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications”, International Journal of Biological Macromolecules, Vol. 48 (1), pp. 112-11810.1016/j.ijbiomac.2010.10.006metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T02:30:44Zoai:ubibliorum.ubi.pt:10400.6/4627Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:41.465711Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications |
title |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications |
spellingShingle |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications Coimbra, Patrícia Polymeric scaffold Polyelectrolyte complexes Cytotoxicity Osteoblasts |
title_short |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications |
title_full |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications |
title_fullStr |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications |
title_full_unstemmed |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications |
title_sort |
Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications |
author |
Coimbra, Patrícia |
author_facet |
Coimbra, Patrícia Ferreira, Paula Sousa, Hermínio C. de Batista, Patrícia Sofia Pinhanços Rodrigues, Miguel Correia, Ilídio Joaquim Sobreira Gil, Maria |
author_role |
author |
author2 |
Ferreira, Paula Sousa, Hermínio C. de Batista, Patrícia Sofia Pinhanços Rodrigues, Miguel Correia, Ilídio Joaquim Sobreira Gil, Maria |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Coimbra, Patrícia Ferreira, Paula Sousa, Hermínio C. de Batista, Patrícia Sofia Pinhanços Rodrigues, Miguel Correia, Ilídio Joaquim Sobreira Gil, Maria |
dc.subject.por.fl_str_mv |
Polymeric scaffold Polyelectrolyte complexes Cytotoxicity Osteoblasts |
topic |
Polymeric scaffold Polyelectrolyte complexes Cytotoxicity Osteoblasts |
description |
In this work, porous scaffolds obtained from the freeze-drying of pectin/chitosan polyelectrolyte complexes were prepared and characterized by FTIR, SEM and weight loss studies. Additionally, the cytotoxicity of the prepared scaffolds was evaluated in vitro, using human osteoblast cells. The results obtained showed that cells adhered to scaffolds and proliferated. The study also confirmed that the degradation by-products of pectin/chitosan scaffold are noncytotoxic. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-10-16 2010-10-16T00:00:00Z 2018-03-19T10:37:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/4627 |
url |
http://hdl.handle.net/10400.6/4627 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Coimbra, P., Ferreira, P., Sousa, H.C., Batista, P., Rodrigues, M.A., Correia, I.J. e Gil, M. H. (2011) “Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications”, International Journal of Biological Macromolecules, Vol. 48 (1), pp. 112-118 10.1016/j.ijbiomac.2010.10.006 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136354411479040 |