Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries

Detalhes bibliográficos
Autor(a) principal: Ougier, Eva
Data de Publicação: 2021
Outros Autores: Fiore, Karine, Rousselle, Christophe, Assunção, Ricardo, Martins, Carla, Buekers, Jurgen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/132987
Resumo: Funding Information: Our thanks to FCT / MCTES for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020), through national funds. Funding Information: The authors received funding from the EU Horizon2020 Framework Project, HBM4EU, Grant number 733032 . Publisher Copyright: © 2021 The Authors
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spelling Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countriesFrance, Spain and BelgiumCadmium (Cd)Disability-adjusted life year (DALY)/Quality-adjusted life year (QALY)Disease burdenHBM4EUHuman biomonitoring (HBM)OsteoporosisPopulation attributable fractionPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingFunding Information: Our thanks to FCT / MCTES for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020), through national funds. Funding Information: The authors received funding from the EU Horizon2020 Framework Project, HBM4EU, Grant number 733032 . Publisher Copyright: © 2021 The AuthorsCadmium (Cd) is a toxic heavy metal widespread in the environment leading to human exposure in particular through diet (when smoking is excluded), as documented by recent human biomonitoring (HBM) surveys. Exposure to Cd at environmental low-exposure levels has been associated with adverse effects such as renal toxicity and more recently bone effects. The implication, even if limited, of Cd in the etiology of osteoporosis can be of high importance at the population level given the significant prevalence of osteoporosis and the ubiquitous and life-long exposure to Cd. Therefore, the osteoporosis cases attributable to Cd exposure was estimated in three European countries (Belgium, France and Spain), based on measured urinary Cd levels from HBM studies conducted in these countries. The targeted population was women over 55 years old, for which risk levels associated with environmental Cd exposure were available. Around 23% of the cases were attributed to Cd exposure. Moreover, in a prospective simulation approach of lifelong urinary Cd concentrations assuming different intakes scenarios, future osteoporosis attributable cases were calculated, based on urinary Cd levels measured in women aged under 55. Between 6 and 34% of the considered populations under 55 years were at risk for osteoporosis. Finally, the costs associated to the burden of osteoporosis-related fractures attributable to Cd for each country targeted in this paper were assessed, standing for a major contributing role of Cd exposure in the overall social costs related to osteoporosis. Absolute costs ranged between 0.12 (low estimate in Belgium) and 2.6 billion Euros (high estimate in France) in women currently over 55 years old and at risk for fractures. Our results support the importance of reducing exposure of the general population to Cd.Centro de Investigação em Saúde Pública (CISP/PHRC)Escola Nacional de Saúde Pública (ENSP)RUNOugier, EvaFiore, KarineRousselle, ChristopheAssunção, RicardoMartins, CarlaBuekers, Jurgen2022-02-15T23:36:58Z2021-052021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/132987eng1438-4639PURE: 41763852https://doi.org/10.1016/j.ijheh.2021.113747info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:11:39Zoai:run.unl.pt:10362/132987Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:39.622626Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
France, Spain and Belgium
title Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
spellingShingle Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
Ougier, Eva
Cadmium (Cd)
Disability-adjusted life year (DALY)/Quality-adjusted life year (QALY)
Disease burden
HBM4EU
Human biomonitoring (HBM)
Osteoporosis
Population attributable fraction
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
title_short Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
title_full Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
title_fullStr Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
title_full_unstemmed Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
title_sort Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries
author Ougier, Eva
author_facet Ougier, Eva
Fiore, Karine
Rousselle, Christophe
Assunção, Ricardo
Martins, Carla
Buekers, Jurgen
author_role author
author2 Fiore, Karine
Rousselle, Christophe
Assunção, Ricardo
Martins, Carla
Buekers, Jurgen
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Investigação em Saúde Pública (CISP/PHRC)
Escola Nacional de Saúde Pública (ENSP)
RUN
dc.contributor.author.fl_str_mv Ougier, Eva
Fiore, Karine
Rousselle, Christophe
Assunção, Ricardo
Martins, Carla
Buekers, Jurgen
dc.subject.por.fl_str_mv Cadmium (Cd)
Disability-adjusted life year (DALY)/Quality-adjusted life year (QALY)
Disease burden
HBM4EU
Human biomonitoring (HBM)
Osteoporosis
Population attributable fraction
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
topic Cadmium (Cd)
Disability-adjusted life year (DALY)/Quality-adjusted life year (QALY)
Disease burden
HBM4EU
Human biomonitoring (HBM)
Osteoporosis
Population attributable fraction
Public Health, Environmental and Occupational Health
SDG 3 - Good Health and Well-being
description Funding Information: Our thanks to FCT / MCTES for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020), through national funds. Funding Information: The authors received funding from the EU Horizon2020 Framework Project, HBM4EU, Grant number 733032 . Publisher Copyright: © 2021 The Authors
publishDate 2021
dc.date.none.fl_str_mv 2021-05
2021-05-01T00:00:00Z
2022-02-15T23:36:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/132987
url http://hdl.handle.net/10362/132987
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1438-4639
PURE: 41763852
https://doi.org/10.1016/j.ijheh.2021.113747
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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