Skeletal Class III phenotype: link between animal models and human genetics: a scoping review

Detalhes bibliográficos
Autor(a) principal: Dehesa‐Santos, Alexandra
Data de Publicação: 2023
Outros Autores: Faria-Teixeira, Maria Cristina, Iglesias‐Linares, Alejandro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/61665
Resumo: © 2023 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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spelling Skeletal Class III phenotype: link between animal models and human genetics: a scoping reviewAnimal modelGenetic variantsMandibular prognathismMaxillary deficiencySkeletal Class III malocclusion phenotype© 2023 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.This study aimed to identify evidence from animal studies examining genetic variants underlying maxillomandibular discrepancies resulting in a skeletal Class III (SCIII) malocclusion phenotype. Following the Manual for Evidence Synthesis of the JBI and the PRISMA extension for scoping reviews, a participant, concept, context question was formulated and systematic searches were executed in the PubMed, Scopus, WOS, Scielo, Open Gray, and Mednar databases. Of the 779 identified studies, 13 met the selection criteria and were included in the data extraction. The SCIII malocclusion phenotype was described as mandibular prognathism in the Danio rerio, Dicentrarchus labrax, and Equus africanus asinus models; and as maxillary deficiency in the Felis silvestris catus, Canis familiaris, Salmo trutta, and Mus musculus models. The identified genetic variants highlight the significance of BMP and TGF-β signaling. Their regulatory pathways and genetic interactions link them to cellular bone regulation events, particularly ossification regulation of postnatal cranial synchondroses. In conclusion, twenty genetic variants associated with the skeletal SCIII malocclusion phenotype were identified in animal models. Their interactions and regulatory pathways corroborate the role of these variants in bone growth, differentiation events, and ossification regulation of postnatal cranial synchondroses.This study was conducted under a pre‐doctoral contract for research personnel in training (CT63/19‐CT64/19). This study was funded by the Complutense University of Madrid and Banco Santander.WileyRepositório da Universidade de LisboaDehesa‐Santos, AlexandraFaria-Teixeira, Maria CristinaIglesias‐Linares, Alejandro2024-01-09T14:46:13Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61665engJ Exp Zool B Mol Dev Evol. 2024 Jan;342(1):21-441552-500710.1002/jez.b.232301552-5015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-15T01:18:20Zoai:repositorio.ul.pt:10451/61665Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:44:30.440736Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
title Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
spellingShingle Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
Dehesa‐Santos, Alexandra
Animal model
Genetic variants
Mandibular prognathism
Maxillary deficiency
Skeletal Class III malocclusion phenotype
title_short Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
title_full Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
title_fullStr Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
title_full_unstemmed Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
title_sort Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
author Dehesa‐Santos, Alexandra
author_facet Dehesa‐Santos, Alexandra
Faria-Teixeira, Maria Cristina
Iglesias‐Linares, Alejandro
author_role author
author2 Faria-Teixeira, Maria Cristina
Iglesias‐Linares, Alejandro
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Dehesa‐Santos, Alexandra
Faria-Teixeira, Maria Cristina
Iglesias‐Linares, Alejandro
dc.subject.por.fl_str_mv Animal model
Genetic variants
Mandibular prognathism
Maxillary deficiency
Skeletal Class III malocclusion phenotype
topic Animal model
Genetic variants
Mandibular prognathism
Maxillary deficiency
Skeletal Class III malocclusion phenotype
description © 2023 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01T00:00:00Z
2024-01-09T14:46:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/61665
url http://hdl.handle.net/10451/61665
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Exp Zool B Mol Dev Evol. 2024 Jan;342(1):21-44
1552-5007
10.1002/jez.b.23230
1552-5015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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