Skeletal Class III phenotype: link between animal models and human genetics: a scoping review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/61665 |
Resumo: | © 2023 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
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Skeletal Class III phenotype: link between animal models and human genetics: a scoping reviewAnimal modelGenetic variantsMandibular prognathismMaxillary deficiencySkeletal Class III malocclusion phenotype© 2023 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.This study aimed to identify evidence from animal studies examining genetic variants underlying maxillomandibular discrepancies resulting in a skeletal Class III (SCIII) malocclusion phenotype. Following the Manual for Evidence Synthesis of the JBI and the PRISMA extension for scoping reviews, a participant, concept, context question was formulated and systematic searches were executed in the PubMed, Scopus, WOS, Scielo, Open Gray, and Mednar databases. Of the 779 identified studies, 13 met the selection criteria and were included in the data extraction. The SCIII malocclusion phenotype was described as mandibular prognathism in the Danio rerio, Dicentrarchus labrax, and Equus africanus asinus models; and as maxillary deficiency in the Felis silvestris catus, Canis familiaris, Salmo trutta, and Mus musculus models. The identified genetic variants highlight the significance of BMP and TGF-β signaling. Their regulatory pathways and genetic interactions link them to cellular bone regulation events, particularly ossification regulation of postnatal cranial synchondroses. In conclusion, twenty genetic variants associated with the skeletal SCIII malocclusion phenotype were identified in animal models. Their interactions and regulatory pathways corroborate the role of these variants in bone growth, differentiation events, and ossification regulation of postnatal cranial synchondroses.This study was conducted under a pre‐doctoral contract for research personnel in training (CT63/19‐CT64/19). This study was funded by the Complutense University of Madrid and Banco Santander.WileyRepositório da Universidade de LisboaDehesa‐Santos, AlexandraFaria-Teixeira, Maria CristinaIglesias‐Linares, Alejandro2024-01-09T14:46:13Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61665engJ Exp Zool B Mol Dev Evol. 2024 Jan;342(1):21-441552-500710.1002/jez.b.232301552-5015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-15T01:18:20Zoai:repositorio.ul.pt:10451/61665Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:44:30.440736Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review |
title |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review |
spellingShingle |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review Dehesa‐Santos, Alexandra Animal model Genetic variants Mandibular prognathism Maxillary deficiency Skeletal Class III malocclusion phenotype |
title_short |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review |
title_full |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review |
title_fullStr |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review |
title_full_unstemmed |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review |
title_sort |
Skeletal Class III phenotype: link between animal models and human genetics: a scoping review |
author |
Dehesa‐Santos, Alexandra |
author_facet |
Dehesa‐Santos, Alexandra Faria-Teixeira, Maria Cristina Iglesias‐Linares, Alejandro |
author_role |
author |
author2 |
Faria-Teixeira, Maria Cristina Iglesias‐Linares, Alejandro |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Dehesa‐Santos, Alexandra Faria-Teixeira, Maria Cristina Iglesias‐Linares, Alejandro |
dc.subject.por.fl_str_mv |
Animal model Genetic variants Mandibular prognathism Maxillary deficiency Skeletal Class III malocclusion phenotype |
topic |
Animal model Genetic variants Mandibular prognathism Maxillary deficiency Skeletal Class III malocclusion phenotype |
description |
© 2023 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals LLC.This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023 2023-01-01T00:00:00Z 2024-01-09T14:46:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/61665 |
url |
http://hdl.handle.net/10451/61665 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Exp Zool B Mol Dev Evol. 2024 Jan;342(1):21-44 1552-5007 10.1002/jez.b.23230 1552-5015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136940844384256 |