Analysis of heart rate variability in a rat model of induced pulmonary hypertension
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://repositorio-aberto.up.pt/handle/10216/67152 |
Resumo: | Monocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine. was weekly recorded during 4 weeks. The first four segments of 1-min length of each HR recording were analysed using linear, time and frequency domains, and approximate (ApEn) and sample (SampEn) entropy indices, considering recently proposed values for the threshold parameter of ApEn and SampEn. Statistical analysis was performed using 95% confidence intervals and statistical tests. Along the study period, an overall weekly maintenance of HR indices, or a decrease, namely in weeks 1-2, was manifest, in the MCT group, except for LF and LF/HF, in week 1, denoting a short-term increase in sympathetic activity without any other changes. On the other hand, a maintenance of HR indices, or an increase, namely on week 4, was observed in the non-MCT group, except for LF/HF, denoting a long-term increase of the overall activity of HR control systems, with a parasympathetic like dominance. Studies on long-term HR dynamics should be performed in very carefully controlled experimental settings, as significant weekly changes may occur, both among anesthetized MCT-treated and non-treated rats. |
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Analysis of heart rate variability in a rat model of induced pulmonary hypertensionBiotecnologia ambientalEnvironmental biotechnologyMonocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine. was weekly recorded during 4 weeks. The first four segments of 1-min length of each HR recording were analysed using linear, time and frequency domains, and approximate (ApEn) and sample (SampEn) entropy indices, considering recently proposed values for the threshold parameter of ApEn and SampEn. Statistical analysis was performed using 95% confidence intervals and statistical tests. Along the study period, an overall weekly maintenance of HR indices, or a decrease, namely in weeks 1-2, was manifest, in the MCT group, except for LF and LF/HF, in week 1, denoting a short-term increase in sympathetic activity without any other changes. On the other hand, a maintenance of HR indices, or an increase, namely on week 4, was observed in the non-MCT group, except for LF/HF, denoting a long-term increase of the overall activity of HR control systems, with a parasympathetic like dominance. Studies on long-term HR dynamics should be performed in very carefully controlled experimental settings, as significant weekly changes may occur, both among anesthetized MCT-treated and non-treated rats.20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/67152eng1350-453310.1016/j.medengphy.2010.04.018Goncalves HHenriques-Coelho TBernardes JRocha APBrandão-Nogueira ALeite-Moreira AFinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:53:40Zoai:repositorio-aberto.up.pt:10216/67152Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:34:45.311608Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension |
title |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension |
spellingShingle |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension Goncalves H Biotecnologia ambiental Environmental biotechnology |
title_short |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension |
title_full |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension |
title_fullStr |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension |
title_full_unstemmed |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension |
title_sort |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension |
author |
Goncalves H |
author_facet |
Goncalves H Henriques-Coelho T Bernardes J Rocha AP Brandão-Nogueira A Leite-Moreira AF |
author_role |
author |
author2 |
Henriques-Coelho T Bernardes J Rocha AP Brandão-Nogueira A Leite-Moreira AF |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Goncalves H Henriques-Coelho T Bernardes J Rocha AP Brandão-Nogueira A Leite-Moreira AF |
dc.subject.por.fl_str_mv |
Biotecnologia ambiental Environmental biotechnology |
topic |
Biotecnologia ambiental Environmental biotechnology |
description |
Monocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine. was weekly recorded during 4 weeks. The first four segments of 1-min length of each HR recording were analysed using linear, time and frequency domains, and approximate (ApEn) and sample (SampEn) entropy indices, considering recently proposed values for the threshold parameter of ApEn and SampEn. Statistical analysis was performed using 95% confidence intervals and statistical tests. Along the study period, an overall weekly maintenance of HR indices, or a decrease, namely in weeks 1-2, was manifest, in the MCT group, except for LF and LF/HF, in week 1, denoting a short-term increase in sympathetic activity without any other changes. On the other hand, a maintenance of HR indices, or an increase, namely on week 4, was observed in the non-MCT group, except for LF/HF, denoting a long-term increase of the overall activity of HR control systems, with a parasympathetic like dominance. Studies on long-term HR dynamics should be performed in very carefully controlled experimental settings, as significant weekly changes may occur, both among anesthetized MCT-treated and non-treated rats. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2010-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio-aberto.up.pt/handle/10216/67152 |
url |
https://repositorio-aberto.up.pt/handle/10216/67152 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1350-4533 10.1016/j.medengphy.2010.04.018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136256087556096 |