Analysis of heart rate variability in a rat model of induced pulmonary hypertension

Detalhes bibliográficos
Autor(a) principal: Goncalves H
Data de Publicação: 2010
Outros Autores: Henriques-Coelho T, Bernardes J, Rocha AP, Brandão-Nogueira A, Leite-Moreira AF
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://repositorio-aberto.up.pt/handle/10216/67152
Resumo: Monocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine. was weekly recorded during 4 weeks. The first four segments of 1-min length of each HR recording were analysed using linear, time and frequency domains, and approximate (ApEn) and sample (SampEn) entropy indices, considering recently proposed values for the threshold parameter of ApEn and SampEn. Statistical analysis was performed using 95% confidence intervals and statistical tests. Along the study period, an overall weekly maintenance of HR indices, or a decrease, namely in weeks 1-2, was manifest, in the MCT group, except for LF and LF/HF, in week 1, denoting a short-term increase in sympathetic activity without any other changes. On the other hand, a maintenance of HR indices, or an increase, namely on week 4, was observed in the non-MCT group, except for LF/HF, denoting a long-term increase of the overall activity of HR control systems, with a parasympathetic like dominance. Studies on long-term HR dynamics should be performed in very carefully controlled experimental settings, as significant weekly changes may occur, both among anesthetized MCT-treated and non-treated rats.
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spelling Analysis of heart rate variability in a rat model of induced pulmonary hypertensionBiotecnologia ambientalEnvironmental biotechnologyMonocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine. was weekly recorded during 4 weeks. The first four segments of 1-min length of each HR recording were analysed using linear, time and frequency domains, and approximate (ApEn) and sample (SampEn) entropy indices, considering recently proposed values for the threshold parameter of ApEn and SampEn. Statistical analysis was performed using 95% confidence intervals and statistical tests. Along the study period, an overall weekly maintenance of HR indices, or a decrease, namely in weeks 1-2, was manifest, in the MCT group, except for LF and LF/HF, in week 1, denoting a short-term increase in sympathetic activity without any other changes. On the other hand, a maintenance of HR indices, or an increase, namely on week 4, was observed in the non-MCT group, except for LF/HF, denoting a long-term increase of the overall activity of HR control systems, with a parasympathetic like dominance. Studies on long-term HR dynamics should be performed in very carefully controlled experimental settings, as significant weekly changes may occur, both among anesthetized MCT-treated and non-treated rats.20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/67152eng1350-453310.1016/j.medengphy.2010.04.018Goncalves HHenriques-Coelho TBernardes JRocha APBrandão-Nogueira ALeite-Moreira AFinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:53:40Zoai:repositorio-aberto.up.pt:10216/67152Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:34:45.311608Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of heart rate variability in a rat model of induced pulmonary hypertension
title Analysis of heart rate variability in a rat model of induced pulmonary hypertension
spellingShingle Analysis of heart rate variability in a rat model of induced pulmonary hypertension
Goncalves H
Biotecnologia ambiental
Environmental biotechnology
title_short Analysis of heart rate variability in a rat model of induced pulmonary hypertension
title_full Analysis of heart rate variability in a rat model of induced pulmonary hypertension
title_fullStr Analysis of heart rate variability in a rat model of induced pulmonary hypertension
title_full_unstemmed Analysis of heart rate variability in a rat model of induced pulmonary hypertension
title_sort Analysis of heart rate variability in a rat model of induced pulmonary hypertension
author Goncalves H
author_facet Goncalves H
Henriques-Coelho T
Bernardes J
Rocha AP
Brandão-Nogueira A
Leite-Moreira AF
author_role author
author2 Henriques-Coelho T
Bernardes J
Rocha AP
Brandão-Nogueira A
Leite-Moreira AF
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Goncalves H
Henriques-Coelho T
Bernardes J
Rocha AP
Brandão-Nogueira A
Leite-Moreira AF
dc.subject.por.fl_str_mv Biotecnologia ambiental
Environmental biotechnology
topic Biotecnologia ambiental
Environmental biotechnology
description Monocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure. In this study, linear and non-linear heart rate (HR) dynamics were weekly assessed in MCT-treated and non-treated Wistar rats. The HR of 10 adult Wistar rats injected with MCT (MCT group) and of 10 similar rats injected with vehicle (non-MCT group), anesthetized with Ketamine. was weekly recorded during 4 weeks. The first four segments of 1-min length of each HR recording were analysed using linear, time and frequency domains, and approximate (ApEn) and sample (SampEn) entropy indices, considering recently proposed values for the threshold parameter of ApEn and SampEn. Statistical analysis was performed using 95% confidence intervals and statistical tests. Along the study period, an overall weekly maintenance of HR indices, or a decrease, namely in weeks 1-2, was manifest, in the MCT group, except for LF and LF/HF, in week 1, denoting a short-term increase in sympathetic activity without any other changes. On the other hand, a maintenance of HR indices, or an increase, namely on week 4, was observed in the non-MCT group, except for LF/HF, denoting a long-term increase of the overall activity of HR control systems, with a parasympathetic like dominance. Studies on long-term HR dynamics should be performed in very carefully controlled experimental settings, as significant weekly changes may occur, both among anesthetized MCT-treated and non-treated rats.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/67152
url https://repositorio-aberto.up.pt/handle/10216/67152
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1350-4533
10.1016/j.medengphy.2010.04.018
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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