Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains

Detalhes bibliográficos
Autor(a) principal: Vinagre, Tânia
Data de Publicação: 2010
Outros Autores: Moncaut, Natalia, Carapuço, Marta, Nóvoa, Ana, Bom, Joana, Mallo, Moisés
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/669
Resumo: Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.
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spelling Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral DomainsAnimalsBone DevelopmentFibroblast Growth FactorsHomeodomain ProteinsMiceMice, TransgenicModels, BiologicalModels, GeneticMuscle DevelopmentMyogenic Regulatory Factor 5Myogenic Regulatory FactorsPhenotypePlatelet-Derived Growth FactorGene Expression Regulation, DevelopmentalHox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.Fundação para a Ciência e a Tecnologia grants: (PTDC/BIA-BCM/71619/2006, POCTI-ISFL-4-664, SFRH/BD/27306/2006, SFRH/BPD/26668/2006).Cell PressARCAVinagre, TâniaMoncaut, NataliaCarapuço, MartaNóvoa, AnaBom, JoanaMallo, Moisés2016-06-28T15:30:11Z2010-04-202010-04-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/669engTânia Vinagre, Natalia Moncaut, Marta Carapuço, Ana Nóvoa, Joana Bom, Moisés Mallo, Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains, Developmental Cell, Volume 18, Issue 4, 20 April 2010, Pages 655-661, ISSN 1534-5807, http://dx.doi.org/10.1016/j.devcel.2010.02.011.10.1016/j.devcel.2010.02.011info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:03Zoai:arca.igc.gulbenkian.pt:10400.7/669Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:54.370179Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
title Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
spellingShingle Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
Vinagre, Tânia
Animals
Bone Development
Fibroblast Growth Factors
Homeodomain Proteins
Mice
Mice, Transgenic
Models, Biological
Models, Genetic
Muscle Development
Myogenic Regulatory Factor 5
Myogenic Regulatory Factors
Phenotype
Platelet-Derived Growth Factor
Gene Expression Regulation, Developmental
title_short Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
title_full Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
title_fullStr Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
title_full_unstemmed Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
title_sort Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains
author Vinagre, Tânia
author_facet Vinagre, Tânia
Moncaut, Natalia
Carapuço, Marta
Nóvoa, Ana
Bom, Joana
Mallo, Moisés
author_role author
author2 Moncaut, Natalia
Carapuço, Marta
Nóvoa, Ana
Bom, Joana
Mallo, Moisés
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Vinagre, Tânia
Moncaut, Natalia
Carapuço, Marta
Nóvoa, Ana
Bom, Joana
Mallo, Moisés
dc.subject.por.fl_str_mv Animals
Bone Development
Fibroblast Growth Factors
Homeodomain Proteins
Mice
Mice, Transgenic
Models, Biological
Models, Genetic
Muscle Development
Myogenic Regulatory Factor 5
Myogenic Regulatory Factors
Phenotype
Platelet-Derived Growth Factor
Gene Expression Regulation, Developmental
topic Animals
Bone Development
Fibroblast Growth Factors
Homeodomain Proteins
Mice
Mice, Transgenic
Models, Biological
Models, Genetic
Muscle Development
Myogenic Regulatory Factor 5
Myogenic Regulatory Factors
Phenotype
Platelet-Derived Growth Factor
Gene Expression Regulation, Developmental
description Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, indicating that Hox genes are also able to specify the thoracic domain. We show that the information provided by Hox genes to specify rib-containing and rib-less areas is first interpreted in the myotome through the regional-specific control of Myf5 and Myf6 expression. This information is then transmitted to the sclerotome by a system that includes FGF and PDGF signaling to produce vertebrae with or without ribs at different axial levels. Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-20
2010-04-20T00:00:00Z
2016-06-28T15:30:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/669
url http://hdl.handle.net/10400.7/669
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tânia Vinagre, Natalia Moncaut, Marta Carapuço, Ana Nóvoa, Joana Bom, Moisés Mallo, Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains, Developmental Cell, Volume 18, Issue 4, 20 April 2010, Pages 655-661, ISSN 1534-5807, http://dx.doi.org/10.1016/j.devcel.2010.02.011.
10.1016/j.devcel.2010.02.011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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