Skin mechanobiology and biomechanics: from homeostasis to wound healing

Detalhes bibliográficos
Autor(a) principal: Fernandes, Maria G.
Data de Publicação: 2019
Outros Autores: Silva, Lucília Pereira, Marques, A. P.
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/61296
Resumo: Human skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed.
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spelling Skin mechanobiology and biomechanics: from homeostasis to wound healingBiomechanicsMechanobiologySkinWound healingScience & TechnologyHuman skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed.(undefined)ElsevierUniversidade do MinhoFernandes, Maria G.Silva, Lucília PereiraMarques, A. P.2019-082019-08-01T00:00:00Zbook partinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/61296engFernandes M. G., da Silva L. P., Marques A. P. Skin Mechanobiology and Biomechanics: From Homeostasis to Wound Healing, Advances in Biomechanics and Tissue Regeneration, pp. 343-360, doi:10.1016/B978-0-12-816390-0.00017-0, 2019978-0-12-816390-010.1016/B978-0-12-816390-0.00017-0https://www.sciencedirect.com/science/article/pii/B9780128163900000170info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:10:46Zoai:repositorium.sdum.uminho.pt:1822/61296Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:10:46Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Skin mechanobiology and biomechanics: from homeostasis to wound healing
title Skin mechanobiology and biomechanics: from homeostasis to wound healing
spellingShingle Skin mechanobiology and biomechanics: from homeostasis to wound healing
Fernandes, Maria G.
Biomechanics
Mechanobiology
Skin
Wound healing
Science & Technology
title_short Skin mechanobiology and biomechanics: from homeostasis to wound healing
title_full Skin mechanobiology and biomechanics: from homeostasis to wound healing
title_fullStr Skin mechanobiology and biomechanics: from homeostasis to wound healing
title_full_unstemmed Skin mechanobiology and biomechanics: from homeostasis to wound healing
title_sort Skin mechanobiology and biomechanics: from homeostasis to wound healing
author Fernandes, Maria G.
author_facet Fernandes, Maria G.
Silva, Lucília Pereira
Marques, A. P.
author_role author
author2 Silva, Lucília Pereira
Marques, A. P.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fernandes, Maria G.
Silva, Lucília Pereira
Marques, A. P.
dc.subject.por.fl_str_mv Biomechanics
Mechanobiology
Skin
Wound healing
Science & Technology
topic Biomechanics
Mechanobiology
Skin
Wound healing
Science & Technology
description Human skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
2019-08-01T00:00:00Z
dc.type.driver.fl_str_mv book part
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/61296
url http://hdl.handle.net/1822/61296
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes M. G., da Silva L. P., Marques A. P. Skin Mechanobiology and Biomechanics: From Homeostasis to Wound Healing, Advances in Biomechanics and Tissue Regeneration, pp. 343-360, doi:10.1016/B978-0-12-816390-0.00017-0, 2019
978-0-12-816390-0
10.1016/B978-0-12-816390-0.00017-0
https://www.sciencedirect.com/science/article/pii/B9780128163900000170
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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