Skin mechanobiology and biomechanics: from homeostasis to wound healing
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/61296 |
Resumo: | Human skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed. |
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Skin mechanobiology and biomechanics: from homeostasis to wound healingBiomechanicsMechanobiologySkinWound healingScience & TechnologyHuman skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed.(undefined)ElsevierUniversidade do MinhoFernandes, Maria G.Silva, Lucília PereiraMarques, A. P.2019-082019-08-01T00:00:00Zbook partinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/61296engFernandes M. G., da Silva L. P., Marques A. P. Skin Mechanobiology and Biomechanics: From Homeostasis to Wound Healing, Advances in Biomechanics and Tissue Regeneration, pp. 343-360, doi:10.1016/B978-0-12-816390-0.00017-0, 2019978-0-12-816390-010.1016/B978-0-12-816390-0.00017-0https://www.sciencedirect.com/science/article/pii/B9780128163900000170info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:10:46Zoai:repositorium.sdum.uminho.pt:1822/61296Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:10:46Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Skin mechanobiology and biomechanics: from homeostasis to wound healing |
title |
Skin mechanobiology and biomechanics: from homeostasis to wound healing |
spellingShingle |
Skin mechanobiology and biomechanics: from homeostasis to wound healing Fernandes, Maria G. Biomechanics Mechanobiology Skin Wound healing Science & Technology |
title_short |
Skin mechanobiology and biomechanics: from homeostasis to wound healing |
title_full |
Skin mechanobiology and biomechanics: from homeostasis to wound healing |
title_fullStr |
Skin mechanobiology and biomechanics: from homeostasis to wound healing |
title_full_unstemmed |
Skin mechanobiology and biomechanics: from homeostasis to wound healing |
title_sort |
Skin mechanobiology and biomechanics: from homeostasis to wound healing |
author |
Fernandes, Maria G. |
author_facet |
Fernandes, Maria G. Silva, Lucília Pereira Marques, A. P. |
author_role |
author |
author2 |
Silva, Lucília Pereira Marques, A. P. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Fernandes, Maria G. Silva, Lucília Pereira Marques, A. P. |
dc.subject.por.fl_str_mv |
Biomechanics Mechanobiology Skin Wound healing Science & Technology |
topic |
Biomechanics Mechanobiology Skin Wound healing Science & Technology |
description |
Human skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08 2019-08-01T00:00:00Z |
dc.type.driver.fl_str_mv |
book part |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/61296 |
url |
http://hdl.handle.net/1822/61296 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fernandes M. G., da Silva L. P., Marques A. P. Skin Mechanobiology and Biomechanics: From Homeostasis to Wound Healing, Advances in Biomechanics and Tissue Regeneration, pp. 343-360, doi:10.1016/B978-0-12-816390-0.00017-0, 2019 978-0-12-816390-0 10.1016/B978-0-12-816390-0.00017-0 https://www.sciencedirect.com/science/article/pii/B9780128163900000170 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545230237302784 |