Vascularization in skin wound healing: where do we stand and where do we go?

Detalhes bibliográficos
Autor(a) principal: Moreira, Helena Rocha
Data de Publicação: 2022
Outros Autores: Marques, A. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/75036
Resumo: Cutaneous healing is a highly complex process that, if altered due to, for example, impaired vascularization, results in chronic wounds or repaired neotissue of poor quality. Significant progress has been achieved in promoting neotissue vascularization during tissue repair/regeneration. In this review, we discuss the strategies that have been explored and how each one of them contributes to regulate vascularization in the context of cutaneous wound healing from two different perspectives â biomaterial-based and a cell-based approaches. Finally, we discuss the implications of these findings on the development of the â next generationâ approaches to target vascularization in wound healing highlighting the importance of going beyond its contribution to regulate vascularization and take into consideration the temporal features of the healing process and of different types of wounds.
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spelling Vascularization in skin wound healing: where do we stand and where do we go?VascularizationWound healingScience & TechnologyCutaneous healing is a highly complex process that, if altered due to, for example, impaired vascularization, results in chronic wounds or repaired neotissue of poor quality. Significant progress has been achieved in promoting neotissue vascularization during tissue repair/regeneration. In this review, we discuss the strategies that have been explored and how each one of them contributes to regulate vascularization in the context of cutaneous wound healing from two different perspectives â biomaterial-based and a cell-based approaches. Finally, we discuss the implications of these findings on the development of the â next generationâ approaches to target vascularization in wound healing highlighting the importance of going beyond its contribution to regulate vascularization and take into consideration the temporal features of the healing process and of different types of wounds.The authors thank the financial support given by the European Research Council through the consolidator grant ‘ECM_INK’ (ERC-2016-COG 726061) and to the FSE/POCH (Fundo Social Europeu através do Programa Operacional do Capital Humano) under the scope of the PD/169/2013, NORTE-08-5369-FSE-000037. Authors would also like to acknowledge BioRender.com as a platform for image creation.ElsevierUniversidade do MinhoMoreira, Helena RochaMarques, A. P.2022-022022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/75036engMoreira H. R., Marques A. P. Vascularization in skin wound healing: where do we stand and where do we go?,, Current Opinion in Biotechnology, Vol. 73, pp. 253-262, doi:10.1016/j.copbio.2021.08.019, 20220958-16691879-042910.1016/j.copbio.2021.08.01934555561https://www.sciencedirect.com/science/article/pii/S0958166921001658info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:09Zoai:repositorium.sdum.uminho.pt:1822/75036Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:42:56.890644Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Vascularization in skin wound healing: where do we stand and where do we go?
title Vascularization in skin wound healing: where do we stand and where do we go?
spellingShingle Vascularization in skin wound healing: where do we stand and where do we go?
Moreira, Helena Rocha
Vascularization
Wound healing
Science & Technology
title_short Vascularization in skin wound healing: where do we stand and where do we go?
title_full Vascularization in skin wound healing: where do we stand and where do we go?
title_fullStr Vascularization in skin wound healing: where do we stand and where do we go?
title_full_unstemmed Vascularization in skin wound healing: where do we stand and where do we go?
title_sort Vascularization in skin wound healing: where do we stand and where do we go?
author Moreira, Helena Rocha
author_facet Moreira, Helena Rocha
Marques, A. P.
author_role author
author2 Marques, A. P.
author2_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Moreira, Helena Rocha
Marques, A. P.
dc.subject.por.fl_str_mv Vascularization
Wound healing
Science & Technology
topic Vascularization
Wound healing
Science & Technology
description Cutaneous healing is a highly complex process that, if altered due to, for example, impaired vascularization, results in chronic wounds or repaired neotissue of poor quality. Significant progress has been achieved in promoting neotissue vascularization during tissue repair/regeneration. In this review, we discuss the strategies that have been explored and how each one of them contributes to regulate vascularization in the context of cutaneous wound healing from two different perspectives â biomaterial-based and a cell-based approaches. Finally, we discuss the implications of these findings on the development of the â next generationâ approaches to target vascularization in wound healing highlighting the importance of going beyond its contribution to regulate vascularization and take into consideration the temporal features of the healing process and of different types of wounds.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
2022-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/75036
url http://hdl.handle.net/1822/75036
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moreira H. R., Marques A. P. Vascularization in skin wound healing: where do we stand and where do we go?,, Current Opinion in Biotechnology, Vol. 73, pp. 253-262, doi:10.1016/j.copbio.2021.08.019, 2022
0958-1669
1879-0429
10.1016/j.copbio.2021.08.019
34555561
https://www.sciencedirect.com/science/article/pii/S0958166921001658
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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