Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices

Detalhes bibliográficos
Autor(a) principal: Henriques, Mariana
Data de Publicação: 2005
Outros Autores: Cerca, Nuno, Azeredo, Joana, Oliveira, Rosário
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/4464
Resumo: Biofilms of Staphyloccocus epidermidis and Candida spp. are two of the most frequent factors of infection and pathogenesis associated to the use of indwelling medical devices. Several strategies have been proposed and/or developed to prevent infection. The aim of this study was to compare the effect of sub-inhibitory concentrations of anti-microbial agents on biofilm formation. Biofilms of three strains of S. epidermidis and two of both Candida albicans and Candida dubliniensis where formed in the presence of three antibiotics and two antifungal agents respectively. Based in the control samples, the percentage of biofilm formation inhibition by the different agents was determined and compared. The results showed that the influence of the antibacterial and antifungal agents tested is strain dependent, with the effect of the different agents also varying among strains, even if they have the same mechanism of action.
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spelling Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devicesAntimicrobial agentsBiofilmCandida albicansCandida dubliniensisStaphylococcuss epidermidisStaphylococcus epidermidisCandida clubliniensisScience & TechnologyBiofilms of Staphyloccocus epidermidis and Candida spp. are two of the most frequent factors of infection and pathogenesis associated to the use of indwelling medical devices. Several strategies have been proposed and/or developed to prevent infection. The aim of this study was to compare the effect of sub-inhibitory concentrations of anti-microbial agents on biofilm formation. Biofilms of three strains of S. epidermidis and two of both Candida albicans and Candida dubliniensis where formed in the presence of three antibiotics and two antifungal agents respectively. Based in the control samples, the percentage of biofilm formation inhibition by the different agents was determined and compared. The results showed that the influence of the antibacterial and antifungal agents tested is strain dependent, with the effect of the different agents also varying among strains, even if they have the same mechanism of action.Fundação para a Ciência e a Tecnologia (FCT).WichtigUniversidade do MinhoHenriques, MarianaCerca, NunoAzeredo, JoanaOliveira, Rosário2005-112005-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/4464eng"International Journal of Artificial Organs". ISSN 1724-6040. 28:11 (2005) 1181-1185.1724-604016353125http://www.artificial-organs.com/index.asp?a=view_issue&id=274info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:25:59Zoai:repositorium.sdum.uminho.pt:1822/4464Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:20:18.336873Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
title Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
spellingShingle Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
Henriques, Mariana
Antimicrobial agents
Biofilm
Candida albicans
Candida dubliniensis
Staphylococcuss epidermidis
Staphylococcus epidermidis
Candida clubliniensis
Science & Technology
title_short Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
title_full Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
title_fullStr Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
title_full_unstemmed Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
title_sort Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices
author Henriques, Mariana
author_facet Henriques, Mariana
Cerca, Nuno
Azeredo, Joana
Oliveira, Rosário
author_role author
author2 Cerca, Nuno
Azeredo, Joana
Oliveira, Rosário
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Henriques, Mariana
Cerca, Nuno
Azeredo, Joana
Oliveira, Rosário
dc.subject.por.fl_str_mv Antimicrobial agents
Biofilm
Candida albicans
Candida dubliniensis
Staphylococcuss epidermidis
Staphylococcus epidermidis
Candida clubliniensis
Science & Technology
topic Antimicrobial agents
Biofilm
Candida albicans
Candida dubliniensis
Staphylococcuss epidermidis
Staphylococcus epidermidis
Candida clubliniensis
Science & Technology
description Biofilms of Staphyloccocus epidermidis and Candida spp. are two of the most frequent factors of infection and pathogenesis associated to the use of indwelling medical devices. Several strategies have been proposed and/or developed to prevent infection. The aim of this study was to compare the effect of sub-inhibitory concentrations of anti-microbial agents on biofilm formation. Biofilms of three strains of S. epidermidis and two of both Candida albicans and Candida dubliniensis where formed in the presence of three antibiotics and two antifungal agents respectively. Based in the control samples, the percentage of biofilm formation inhibition by the different agents was determined and compared. The results showed that the influence of the antibacterial and antifungal agents tested is strain dependent, with the effect of the different agents also varying among strains, even if they have the same mechanism of action.
publishDate 2005
dc.date.none.fl_str_mv 2005-11
2005-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/4464
url http://hdl.handle.net/1822/4464
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "International Journal of Artificial Organs". ISSN 1724-6040. 28:11 (2005) 1181-1185.
1724-6040
16353125
http://www.artificial-organs.com/index.asp?a=view_issue&id=274
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wichtig
publisher.none.fl_str_mv Wichtig
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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