Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection

Detalhes bibliográficos
Autor(a) principal: Vaz, Mariana
Data de Publicação: 2022
Outros Autores: Pires, Damiana, Pires, Pedro, Simões, Marco, Pombo, Ana, Santos, Paulo, Carmo, Beatriz do, Passos, Ricardo, Costa, Janina Z., Thompson, Kim D., Baptista, Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/6911
Resumo: Funding: This study was supported by Fundação para a Ciência e Tecnologia (FCT) through the strategic projects UIDB /04292/2020 and UIDP/04292/2020 granted to MARE and the project MAR02.05.01-FEAMP-0013.
id RCAP_7cf2ee486cc517e4dad4f4593eb2d662
oai_identifier_str oai:iconline.ipleiria.pt:10400.8/6911
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infectionEuropean seabassNervous necrosis virusBetanodavirusHematologyOxidative stressFish immunityFunding: This study was supported by Fundação para a Ciência e Tecnologia (FCT) through the strategic projects UIDB /04292/2020 and UIDP/04292/2020 granted to MARE and the project MAR02.05.01-FEAMP-0013.The early host–pathogen interaction between European seabass (Dicentrarchus labrax) and Betanodavirus was examined by using juvenile fish infected intramuscularly with RGNNV (red-spotted grouper nervous necrosis virus). The time course selected for sampling (0–144 h post-infection (hpi)) covered the early stages of infection, with hematological, antioxidant and immunological responses examined. Early activation of the host’s immune system was seen in the first few hours post-infection (6 to 9 hpi), as evidenced by an increase in tnfa, cd28 and c3 expression in the head kidney of infected fish. Most hematological parameters that were examined showed significant differences between sampling times, including differences in the number of thrombocytes and various leukocyte populations. The plasma lysozyme concentration decreased significantly over the course of the trial, and most antioxidant parameters examined in the liver showed significant differences over the infection period. At 144 hpi, peak expression of tnfa and il-1b coincided with the appearance of disease symptoms, peak levels of virus in the brain and high levels of fish mortality. The results of the study show the importance of analyzing the early interactions between European seabass and Betanodavirus to establish early indicators of infection to prevent more severe outcomes of the infection from occurring.MDPIIC-OnlineVaz, MarianaPires, DamianaPires, PedroSimões, MarcoPombo, AnaSantos, PauloCarmo, Beatriz doPassos, RicardoCosta, Janina Z.Thompson, Kim D.Baptista, Teresa2022-04-04T14:54:59Z20222022-03-25T18:29:00Z2022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/6911engVaz, M.; Pires, D.; Pires, P.; Simões, M.; Pombo, A.; Santos, P.; do Carmo, B.; Passos, R.; Costa, J.Z.; Thompson, K.D.; et al. Early Immune Modulation in European Seabass (Dicentrarchus labrax) Juveniles in Response to Betanodavirus Infection. Fishes 2022, 7, 63. https://doi.org/ 10.3390/fishes70200632410-3888cv-prod-296245610.3390/fishes7020063info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:54:03Zoai:iconline.ipleiria.pt:10400.8/6911Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:59.186082Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
title Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
spellingShingle Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
Vaz, Mariana
European seabass
Nervous necrosis virus
Betanodavirus
Hematology
Oxidative stress
Fish immunity
title_short Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
title_full Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
title_fullStr Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
title_full_unstemmed Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
title_sort Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection
author Vaz, Mariana
author_facet Vaz, Mariana
Pires, Damiana
Pires, Pedro
Simões, Marco
Pombo, Ana
Santos, Paulo
Carmo, Beatriz do
Passos, Ricardo
Costa, Janina Z.
Thompson, Kim D.
Baptista, Teresa
author_role author
author2 Pires, Damiana
Pires, Pedro
Simões, Marco
Pombo, Ana
Santos, Paulo
Carmo, Beatriz do
Passos, Ricardo
Costa, Janina Z.
Thompson, Kim D.
Baptista, Teresa
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Vaz, Mariana
Pires, Damiana
Pires, Pedro
Simões, Marco
Pombo, Ana
Santos, Paulo
Carmo, Beatriz do
Passos, Ricardo
Costa, Janina Z.
Thompson, Kim D.
Baptista, Teresa
dc.subject.por.fl_str_mv European seabass
Nervous necrosis virus
Betanodavirus
Hematology
Oxidative stress
Fish immunity
topic European seabass
Nervous necrosis virus
Betanodavirus
Hematology
Oxidative stress
Fish immunity
description Funding: This study was supported by Fundação para a Ciência e Tecnologia (FCT) through the strategic projects UIDB /04292/2020 and UIDP/04292/2020 granted to MARE and the project MAR02.05.01-FEAMP-0013.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-04T14:54:59Z
2022
2022-03-25T18:29:00Z
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/6911
url http://hdl.handle.net/10400.8/6911
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vaz, M.; Pires, D.; Pires, P.; Simões, M.; Pombo, A.; Santos, P.; do Carmo, B.; Passos, R.; Costa, J.Z.; Thompson, K.D.; et al. Early Immune Modulation in European Seabass (Dicentrarchus labrax) Juveniles in Response to Betanodavirus Infection. Fishes 2022, 7, 63. https://doi.org/ 10.3390/fishes7020063
2410-3888
cv-prod-2962456
10.3390/fishes7020063
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799136992281231360

Registros relacionados