Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/32986 |
Resumo: | The link between brain iron homeostasis and neurodegenerative disease has been the subject of extensive research. There is increasing evidence of iron accumulation during ageing, and altered iron levels in some specific brain regions in neurodegenerative disease patients have been reported. Using graphite furnace atomic absorption spectrometry after microwave-assisted acid digestion of the samples, iron levels were determined in 14 different areas of the human brain [frontal cortex, superior and middle temporal, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons (locus coeruleus), medulla and cerebellum (dentate nucleus)] of n=42 adult individuals (71±12 years old, range: 53-101 years old) with no known history or evidence of neurodegenerative, neurological or psychiatric disorders. It was found that the iron distribution in the adult human brain is quite heterogeneous. The highest levels were found in the putamen (mean±SD, range: 855±295µg/g, 304-1628µg/g) and globus pallidus (739±390µg/g, 225-1870µg/g), and the lowest levels were observed in the pons (98±43µg/g, 11-253µg/g) and medulla (56±25µg/g, 13-115µg/g). Globally, iron levels proved to be age-related. The positive correlation between iron levels and age was most significant in the basal ganglia (caudate nucleus, putamen and globus pallidus). Compared with the age-matched control group, altered iron levels were observed in specific brain areas of one Parkinson's disease patient (the basal ganglia) and two Alzheimer's disease patients (the hippocampus). |
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Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changesHuman brainIron levelsPost - mortem analysisAgeingNeurodegenerative diseasesPost-mortem analysisScience & TechnologyThe link between brain iron homeostasis and neurodegenerative disease has been the subject of extensive research. There is increasing evidence of iron accumulation during ageing, and altered iron levels in some specific brain regions in neurodegenerative disease patients have been reported. Using graphite furnace atomic absorption spectrometry after microwave-assisted acid digestion of the samples, iron levels were determined in 14 different areas of the human brain [frontal cortex, superior and middle temporal, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons (locus coeruleus), medulla and cerebellum (dentate nucleus)] of n=42 adult individuals (71±12 years old, range: 53-101 years old) with no known history or evidence of neurodegenerative, neurological or psychiatric disorders. It was found that the iron distribution in the adult human brain is quite heterogeneous. The highest levels were found in the putamen (mean±SD, range: 855±295µg/g, 304-1628µg/g) and globus pallidus (739±390µg/g, 225-1870µg/g), and the lowest levels were observed in the pons (98±43µg/g, 11-253µg/g) and medulla (56±25µg/g, 13-115µg/g). Globally, iron levels proved to be age-related. The positive correlation between iron levels and age was most significant in the basal ganglia (caudate nucleus, putamen and globus pallidus). Compared with the age-matched control group, altered iron levels were observed in specific brain areas of one Parkinson's disease patient (the basal ganglia) and two Alzheimer's disease patients (the hippocampus).The authors thank the Universidade do Porto and Santander Totta for financial support through the project "TRAIN: Trace elements in human brain: age-related changes and anatomic region specific differences" (PP_IJUP 2011 342).ElsevierUniversidade do MinhoRamos, PatríciaSantos, AgostinhoPinto, Nair RosasMendes, RicardoMagalhães, TeresaAlmeida, Agostinho20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32986eng0946-672X10.1016/j.jtemb.2013.08.00124075790http://www.elsevier.com/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:29:38Zoai:repositorium.sdum.uminho.pt:1822/32986Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:24:40.030819Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
title |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
spellingShingle |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes Ramos, Patrícia Human brain Iron levels Post - mortem analysis Ageing Neurodegenerative diseases Post-mortem analysis Science & Technology |
title_short |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
title_full |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
title_fullStr |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
title_full_unstemmed |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
title_sort |
Iron levels in the human brain: a post-morten study of anatomical region differences and age-related changes |
author |
Ramos, Patrícia |
author_facet |
Ramos, Patrícia Santos, Agostinho Pinto, Nair Rosas Mendes, Ricardo Magalhães, Teresa Almeida, Agostinho |
author_role |
author |
author2 |
Santos, Agostinho Pinto, Nair Rosas Mendes, Ricardo Magalhães, Teresa Almeida, Agostinho |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ramos, Patrícia Santos, Agostinho Pinto, Nair Rosas Mendes, Ricardo Magalhães, Teresa Almeida, Agostinho |
dc.subject.por.fl_str_mv |
Human brain Iron levels Post - mortem analysis Ageing Neurodegenerative diseases Post-mortem analysis Science & Technology |
topic |
Human brain Iron levels Post - mortem analysis Ageing Neurodegenerative diseases Post-mortem analysis Science & Technology |
description |
The link between brain iron homeostasis and neurodegenerative disease has been the subject of extensive research. There is increasing evidence of iron accumulation during ageing, and altered iron levels in some specific brain regions in neurodegenerative disease patients have been reported. Using graphite furnace atomic absorption spectrometry after microwave-assisted acid digestion of the samples, iron levels were determined in 14 different areas of the human brain [frontal cortex, superior and middle temporal, caudate nucleus, putamen, globus pallidus, cingulated gyrus, hippocampus, inferior parietal lobule, visual cortex of the occipital lobe, midbrain, pons (locus coeruleus), medulla and cerebellum (dentate nucleus)] of n=42 adult individuals (71±12 years old, range: 53-101 years old) with no known history or evidence of neurodegenerative, neurological or psychiatric disorders. It was found that the iron distribution in the adult human brain is quite heterogeneous. The highest levels were found in the putamen (mean±SD, range: 855±295µg/g, 304-1628µg/g) and globus pallidus (739±390µg/g, 225-1870µg/g), and the lowest levels were observed in the pons (98±43µg/g, 11-253µg/g) and medulla (56±25µg/g, 13-115µg/g). Globally, iron levels proved to be age-related. The positive correlation between iron levels and age was most significant in the basal ganglia (caudate nucleus, putamen and globus pallidus). Compared with the age-matched control group, altered iron levels were observed in specific brain areas of one Parkinson's disease patient (the basal ganglia) and two Alzheimer's disease patients (the hippocampus). |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/32986 |
url |
http://hdl.handle.net/1822/32986 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0946-672X 10.1016/j.jtemb.2013.08.001 24075790 http://www.elsevier.com/ |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132727839031296 |