Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/18765 |
Resumo: | To characterize 2-year changes occurring in neurodegeneration, edema, and capillary dropout in nonproliferative diabetic retinopathy. Two-year prospective longitudinal observational cohort of eyes/patients with type 2 diabetes using spectral domain optical coherence tomography (SD-OCT) and opti cal coherence tomography angiography (OCTA). Eyes were examined three times with intervals of 1 year. Thickness of the full retina and layer-by-layer measurements were used to identify edema or neurodegeneration. OCTA vessel density maps of the retina were used to identify capillary dropout. Early Treatment Diabetic Retinopathy Study (ETDRS) classification was performed using the seven-field ETDRS protocol. A total of 62 eyes from 62 patients with diabetes were followed for 2 years. After verification for image quality, a total of 44 eyes from 44 patients (30% women) aged 52 to 80 years were retained for data analysis. There were 18 eyes with ETDRS grades 10 to 20, 17 eyes with ETDRS grade 35, and 9 eyes with ETDRS grades 43 to 47. During the 2-year follow-up period, there was a progressive increase in capillary dropout, whereas edema and neurodegeneration remained stable. In multivariate analysis, consid ering a model adjusted for age, sex, hemoglobin A1C, visual acuity, and diabetes duration, vessel density remained significantly different between Diabetic Retinopathy Severity Scale groups (Wilks’ λ = 0.707; P = 0.015) showing association with disease progression. Capillary dropout increased in a period of 2 years in eyes with minimal, mild, and moderate diabetic retinopathy, whereas the presence of edema and neurodegeneration remained stable |
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Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal studyRetinopathyDiabetesTo characterize 2-year changes occurring in neurodegeneration, edema, and capillary dropout in nonproliferative diabetic retinopathy. Two-year prospective longitudinal observational cohort of eyes/patients with type 2 diabetes using spectral domain optical coherence tomography (SD-OCT) and opti cal coherence tomography angiography (OCTA). Eyes were examined three times with intervals of 1 year. Thickness of the full retina and layer-by-layer measurements were used to identify edema or neurodegeneration. OCTA vessel density maps of the retina were used to identify capillary dropout. Early Treatment Diabetic Retinopathy Study (ETDRS) classification was performed using the seven-field ETDRS protocol. A total of 62 eyes from 62 patients with diabetes were followed for 2 years. After verification for image quality, a total of 44 eyes from 44 patients (30% women) aged 52 to 80 years were retained for data analysis. There were 18 eyes with ETDRS grades 10 to 20, 17 eyes with ETDRS grade 35, and 9 eyes with ETDRS grades 43 to 47. During the 2-year follow-up period, there was a progressive increase in capillary dropout, whereas edema and neurodegeneration remained stable. In multivariate analysis, consid ering a model adjusted for age, sex, hemoglobin A1C, visual acuity, and diabetes duration, vessel density remained significantly different between Diabetic Retinopathy Severity Scale groups (Wilks’ λ = 0.707; P = 0.015) showing association with disease progression. Capillary dropout increased in a period of 2 years in eyes with minimal, mild, and moderate diabetic retinopathy, whereas the presence of edema and neurodegeneration remained stableARVORepositório Científico do Instituto Politécnico do PortoMarques, Inês P.Alves, DalilaSantos, TorcatoMendes, LuísLobo, ConceiçãoSantos, Ana RitaDurbin, MaryCunha-Vaz, José2021-10-22T09:05:28Z2020-082020-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/18765engMarques, I. P., Alves, D., Santos, T., Mendes, L., Lobo, C., Santos, A. R., Durbin, M., & Cunha-Vaz, J. (2020). Characterization of Disease Progression in the Initial Stages of Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study. Investigative Ophthalmology and Visual Science, 61(3), 20-20. https://doi.org/10.1167/iovs.61.3.201552-578310.1167/iovs.61.3.20info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:11:48ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study |
title |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study |
spellingShingle |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study Marques, Inês P. Retinopathy Diabetes |
title_short |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study |
title_full |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study |
title_fullStr |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study |
title_full_unstemmed |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study |
title_sort |
Characterization of disease progression in the initial stages of retinopathy in type 2 diabetes: A 2-year longitudinal study |
author |
Marques, Inês P. |
author_facet |
Marques, Inês P. Alves, Dalila Santos, Torcato Mendes, Luís Lobo, Conceição Santos, Ana Rita Durbin, Mary Cunha-Vaz, José |
author_role |
author |
author2 |
Alves, Dalila Santos, Torcato Mendes, Luís Lobo, Conceição Santos, Ana Rita Durbin, Mary Cunha-Vaz, José |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Marques, Inês P. Alves, Dalila Santos, Torcato Mendes, Luís Lobo, Conceição Santos, Ana Rita Durbin, Mary Cunha-Vaz, José |
dc.subject.por.fl_str_mv |
Retinopathy Diabetes |
topic |
Retinopathy Diabetes |
description |
To characterize 2-year changes occurring in neurodegeneration, edema, and capillary dropout in nonproliferative diabetic retinopathy. Two-year prospective longitudinal observational cohort of eyes/patients with type 2 diabetes using spectral domain optical coherence tomography (SD-OCT) and opti cal coherence tomography angiography (OCTA). Eyes were examined three times with intervals of 1 year. Thickness of the full retina and layer-by-layer measurements were used to identify edema or neurodegeneration. OCTA vessel density maps of the retina were used to identify capillary dropout. Early Treatment Diabetic Retinopathy Study (ETDRS) classification was performed using the seven-field ETDRS protocol. A total of 62 eyes from 62 patients with diabetes were followed for 2 years. After verification for image quality, a total of 44 eyes from 44 patients (30% women) aged 52 to 80 years were retained for data analysis. There were 18 eyes with ETDRS grades 10 to 20, 17 eyes with ETDRS grade 35, and 9 eyes with ETDRS grades 43 to 47. During the 2-year follow-up period, there was a progressive increase in capillary dropout, whereas edema and neurodegeneration remained stable. In multivariate analysis, consid ering a model adjusted for age, sex, hemoglobin A1C, visual acuity, and diabetes duration, vessel density remained significantly different between Diabetic Retinopathy Severity Scale groups (Wilks’ λ = 0.707; P = 0.015) showing association with disease progression. Capillary dropout increased in a period of 2 years in eyes with minimal, mild, and moderate diabetic retinopathy, whereas the presence of edema and neurodegeneration remained stable |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08 2020-08-01T00:00:00Z 2021-10-22T09:05:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/18765 |
url |
http://hdl.handle.net/10400.22/18765 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marques, I. P., Alves, D., Santos, T., Mendes, L., Lobo, C., Santos, A. R., Durbin, M., & Cunha-Vaz, J. (2020). Characterization of Disease Progression in the Initial Stages of Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study. Investigative Ophthalmology and Visual Science, 61(3), 20-20. https://doi.org/10.1167/iovs.61.3.20 1552-5783 10.1167/iovs.61.3.20 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ARVO |
publisher.none.fl_str_mv |
ARVO |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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