Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/100139 https://doi.org/10.1016/j.jct.2021.106533 |
Resumo: | Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol. kg1. These data were complemented by viscosity measurements. The overall information allows to compute descriptive parameters and further interpretation on the basis of well-established models. |
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Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics5-FluorouracilOncologic drugs transport propertiesAqueous solutionsBinary mutual diffusionCancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol. kg1. These data were complemented by viscosity measurements. The overall information allows to compute descriptive parameters and further interpretation on the basis of well-established models.8E1D-B2A5-3B37 | Luis Manuel Pires Verissimoinfo:eu-repo/semantics/publishedVersionElsevier2021-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/100139http://hdl.handle.net/10316/100139https://doi.org/10.1016/j.jct.2021.106533eng0021-9614cv-prod-2571833Verissimo, Luis M. P.Cabral, InêsCabral, Ana M. T. D. P. V.Utzeri, GianlucaVeiga, Francisco J. B.Valente, Artur J. M.Ribeiro, Ana C. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-16T20:46:34Zoai:estudogeral.uc.pt:10316/100139Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:17:35.766729Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics |
title |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics |
spellingShingle |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics Verissimo, Luis M. P. 5-Fluorouracil Oncologic drugs transport properties Aqueous solutions Binary mutual diffusion |
title_short |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics |
title_full |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics |
title_fullStr |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics |
title_full_unstemmed |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics |
title_sort |
Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics |
author |
Verissimo, Luis M. P. |
author_facet |
Verissimo, Luis M. P. Cabral, Inês Cabral, Ana M. T. D. P. V. Utzeri, Gianluca Veiga, Francisco J. B. Valente, Artur J. M. Ribeiro, Ana C. F. |
author_role |
author |
author2 |
Cabral, Inês Cabral, Ana M. T. D. P. V. Utzeri, Gianluca Veiga, Francisco J. B. Valente, Artur J. M. Ribeiro, Ana C. F. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Verissimo, Luis M. P. Cabral, Inês Cabral, Ana M. T. D. P. V. Utzeri, Gianluca Veiga, Francisco J. B. Valente, Artur J. M. Ribeiro, Ana C. F. |
dc.subject.por.fl_str_mv |
5-Fluorouracil Oncologic drugs transport properties Aqueous solutions Binary mutual diffusion |
topic |
5-Fluorouracil Oncologic drugs transport properties Aqueous solutions Binary mutual diffusion |
description |
Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol. kg1. These data were complemented by viscosity measurements. The overall information allows to compute descriptive parameters and further interpretation on the basis of well-established models. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/100139 http://hdl.handle.net/10316/100139 https://doi.org/10.1016/j.jct.2021.106533 |
url |
http://hdl.handle.net/10316/100139 https://doi.org/10.1016/j.jct.2021.106533 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0021-9614 cv-prod-2571833 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134071426646016 |