Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/14209 |
Resumo: | Introduction: The human lower limb is widely used as a model to study in vivo microcirculatory physiology and pathophysiology. It is a preferential target for critical comorbidities (overweight, diabetes, and peripheral vascular disease). Movement and activity are consistently regarded as beneficial, but the related adaptive physiology is still poorly understood. Our goal was to better identify the foot microcirculatory changes after a regular walking gait activity in healthy subjects of different ages. Methods: Twelve healthy participants of both sexes, with normal BMI and Ankle-Brachial Index, were selected and grouped according to age - group I (21.0 ± 1 y.o.) and group II (55.8 ± 3 y.o.). The protocol involved 2 phases of 5-min duration each - phase 1, a static standing position, and phase 2, 5-min walking with a comfortable pace on a pre-established circuit. Perfusion changes were assessed in the dorsal region of both feet before (baseline, phase 1) and after (phase 2) the gait period by noninvasive optical technologies - laser Doppler flowmetry (LDF), photoplethysmography, and polarized spectroscopy (PSp). Comparative statistics were performed with a 95% confidence level. Results: All instruments detected asymmetric nonsignificant perfusion between right and left feet during rest in all participants with values in females consistently lower than men. Older participants exhibited lower baseline values than the younger group. Gait evoked a perfusion reduction in all participants relative to phase 1 detected with all technologies, with statistically significant changes recorded with LDF (group I, p = 0.033, and group II, p = 0.028) and PSp (group II, p = 0.041). Furthermore, LDF revealed that gait significantly reduced perfusion velocity in the older group (p = 0.003). Corresponding changes in the younger group were present but discrete. Recovery to baseline levels was also slower in the older group. Discussion/Conclusions: Our results confirm that perfusion is age-dependent and demonstrate the clinical relevance of simple dynamic activities such as gait. This reduction of the dorsal foot perfusion occurs in-depth, being more pronounced with the movement intensity, suggesting a wide application potential in early diagnostics as for rehabilitation. |
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Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adultsDorsal foot microcirculationLaser Doppler flowmetryPhotoplethysmographyPolarized spectroscopyWalking gaitIntroduction: The human lower limb is widely used as a model to study in vivo microcirculatory physiology and pathophysiology. It is a preferential target for critical comorbidities (overweight, diabetes, and peripheral vascular disease). Movement and activity are consistently regarded as beneficial, but the related adaptive physiology is still poorly understood. Our goal was to better identify the foot microcirculatory changes after a regular walking gait activity in healthy subjects of different ages. Methods: Twelve healthy participants of both sexes, with normal BMI and Ankle-Brachial Index, were selected and grouped according to age - group I (21.0 ± 1 y.o.) and group II (55.8 ± 3 y.o.). The protocol involved 2 phases of 5-min duration each - phase 1, a static standing position, and phase 2, 5-min walking with a comfortable pace on a pre-established circuit. Perfusion changes were assessed in the dorsal region of both feet before (baseline, phase 1) and after (phase 2) the gait period by noninvasive optical technologies - laser Doppler flowmetry (LDF), photoplethysmography, and polarized spectroscopy (PSp). Comparative statistics were performed with a 95% confidence level. Results: All instruments detected asymmetric nonsignificant perfusion between right and left feet during rest in all participants with values in females consistently lower than men. Older participants exhibited lower baseline values than the younger group. Gait evoked a perfusion reduction in all participants relative to phase 1 detected with all technologies, with statistically significant changes recorded with LDF (group I, p = 0.033, and group II, p = 0.028) and PSp (group II, p = 0.041). Furthermore, LDF revealed that gait significantly reduced perfusion velocity in the older group (p = 0.003). Corresponding changes in the younger group were present but discrete. Recovery to baseline levels was also slower in the older group. Discussion/Conclusions: Our results confirm that perfusion is age-dependent and demonstrate the clinical relevance of simple dynamic activities such as gait. This reduction of the dorsal foot perfusion occurs in-depth, being more pronounced with the movement intensity, suggesting a wide application potential in early diagnostics as for rehabilitation.KargerRCIPLFlorindo, MargaridaNuno, Sérgio LoureiroRodrigues, Luis Monteiro2022-01-26T14:46:30Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14209engFlorindo M, Nuno SL, Rodrigues LM. Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults. Skin Pharmacol Physiol. 2022;35(1):13-22.10.1159/000517906info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:10:03Zoai:repositorio.ipl.pt:10400.21/14209Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:03.596305Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults |
title |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults |
spellingShingle |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults Florindo, Margarida Dorsal foot microcirculation Laser Doppler flowmetry Photoplethysmography Polarized spectroscopy Walking gait |
title_short |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults |
title_full |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults |
title_fullStr |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults |
title_full_unstemmed |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults |
title_sort |
Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults |
author |
Florindo, Margarida |
author_facet |
Florindo, Margarida Nuno, Sérgio Loureiro Rodrigues, Luis Monteiro |
author_role |
author |
author2 |
Nuno, Sérgio Loureiro Rodrigues, Luis Monteiro |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Florindo, Margarida Nuno, Sérgio Loureiro Rodrigues, Luis Monteiro |
dc.subject.por.fl_str_mv |
Dorsal foot microcirculation Laser Doppler flowmetry Photoplethysmography Polarized spectroscopy Walking gait |
topic |
Dorsal foot microcirculation Laser Doppler flowmetry Photoplethysmography Polarized spectroscopy Walking gait |
description |
Introduction: The human lower limb is widely used as a model to study in vivo microcirculatory physiology and pathophysiology. It is a preferential target for critical comorbidities (overweight, diabetes, and peripheral vascular disease). Movement and activity are consistently regarded as beneficial, but the related adaptive physiology is still poorly understood. Our goal was to better identify the foot microcirculatory changes after a regular walking gait activity in healthy subjects of different ages. Methods: Twelve healthy participants of both sexes, with normal BMI and Ankle-Brachial Index, were selected and grouped according to age - group I (21.0 ± 1 y.o.) and group II (55.8 ± 3 y.o.). The protocol involved 2 phases of 5-min duration each - phase 1, a static standing position, and phase 2, 5-min walking with a comfortable pace on a pre-established circuit. Perfusion changes were assessed in the dorsal region of both feet before (baseline, phase 1) and after (phase 2) the gait period by noninvasive optical technologies - laser Doppler flowmetry (LDF), photoplethysmography, and polarized spectroscopy (PSp). Comparative statistics were performed with a 95% confidence level. Results: All instruments detected asymmetric nonsignificant perfusion between right and left feet during rest in all participants with values in females consistently lower than men. Older participants exhibited lower baseline values than the younger group. Gait evoked a perfusion reduction in all participants relative to phase 1 detected with all technologies, with statistically significant changes recorded with LDF (group I, p = 0.033, and group II, p = 0.028) and PSp (group II, p = 0.041). Furthermore, LDF revealed that gait significantly reduced perfusion velocity in the older group (p = 0.003). Corresponding changes in the younger group were present but discrete. Recovery to baseline levels was also slower in the older group. Discussion/Conclusions: Our results confirm that perfusion is age-dependent and demonstrate the clinical relevance of simple dynamic activities such as gait. This reduction of the dorsal foot perfusion occurs in-depth, being more pronounced with the movement intensity, suggesting a wide application potential in early diagnostics as for rehabilitation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-26T14:46:30Z 2022-01 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/14209 |
url |
http://hdl.handle.net/10400.21/14209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Florindo M, Nuno SL, Rodrigues LM. Lower limb dynamic activity significantly reduces foot skin perfusion: exploring data with different optical sensors in age-grouped healthy adults. Skin Pharmacol Physiol. 2022;35(1):13-22. 10.1159/000517906 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Karger |
publisher.none.fl_str_mv |
Karger |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133491866107904 |