PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications

Detalhes bibliográficos
Autor(a) principal: Fernandes, J. G.
Data de Publicação: 2014
Outros Autores: Correia, D. M., Botelho, Gabriela, Padrão, Jorge, Dourado, Fernando, Ribeiro, C., Lanceros-Méndez, S., Sencadas, Vítor João Gomes Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/31682
Resumo: Fiber meshes of poly(hydroxybutyrate) (PHB) and poly(hydroxybutyrate)/poly(ethylene oxide) (PHB/PEO) with different concentrations of chlorhexidine (CHX) were prepared by electrospinning for assessment as a polymer based drug delivery system. The electrospun fibers were characterized at morphological, molecular and mechanical levels. The bactericidal potential of PHB and PHB/PEO electrospun fibers, with and without CHX, was investigated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by disk diffusion susceptibility tests. Electrospun fibers containing CHX exhibited bactericidal activity. PHB/PEO-1%CHX displayed higher CHX release levels and equivalent antibacterial activity when compared to PHB/PEO with 5 and 10 wt% CHX. Bactericidal performance of samples with 1 wt% CHX was assessed by Colony Forming Units (CFU), where reductions of 100% and 99.69% against E. coli and S. aureus were achieved, respectively.
id RCAP_7e00cb4a32fb0f74571fd82cd691759e
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/31682
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applicationsElectrospun fibersDrug release kineticsAntibacterial activityBiopolymersChlorhexidineScience & TechnologyFiber meshes of poly(hydroxybutyrate) (PHB) and poly(hydroxybutyrate)/poly(ethylene oxide) (PHB/PEO) with different concentrations of chlorhexidine (CHX) were prepared by electrospinning for assessment as a polymer based drug delivery system. The electrospun fibers were characterized at morphological, molecular and mechanical levels. The bactericidal potential of PHB and PHB/PEO electrospun fibers, with and without CHX, was investigated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by disk diffusion susceptibility tests. Electrospun fibers containing CHX exhibited bactericidal activity. PHB/PEO-1%CHX displayed higher CHX release levels and equivalent antibacterial activity when compared to PHB/PEO with 5 and 10 wt% CHX. Bactericidal performance of samples with 1 wt% CHX was assessed by Colony Forming Units (CFU), where reductions of 100% and 99.69% against E. coli and S. aureus were achieved, respectively.This work was supported by FEDER through the COMPETE Program and by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Project PEST-C/FIS/UI607/2011 and PEST-C/QUI/UIO686/2011. The authors also thank funding from Matepro - Optimizing Materials and Processes", ref. NORTE-07-0124-FEDER-000037", co-funded by the "Programa Operacional Regional do Norte" (ON.2 - O Novo Norte), under the "Quadro de Referencia Estrategico Nacional" (QREN), through the "Fundo Europeu de Desenvolvimento Regional" (FEDER). D.M.C, JP and VS thanks the FCT for the, SFRH/BD/82411/2011, SFRH/BD/64901/2009 and SFRH/BPD/63148/2009 grants respectively. The authors also thank support from the COST Action MP1003, 2010 'European Scientific Network for Artificial Muscles' and to the COST Action MP1206 'Electrospun Nano-fibres for Bio inspired Composite Materials and Innovative Industrial Applications'. The authors also thank prof. Jose Luis Gomez Ribelles from the Unversidad Politecnica de Valencia, Spain, for interesting discussions on these issues.Elsevier B.V.Universidade do MinhoFernandes, J. G.Correia, D. M.Botelho, GabrielaPadrão, JorgeDourado, FernandoRibeiro, C.Lanceros-Méndez, S.Sencadas, Vítor João Gomes Silva20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/31682engFernandes, J. G.; Correia, D. M.; Botelho, G.; Padrão, J.; Dourado, Fernando; Ribeiro, C.; Lanceros-Méndez, S.; Sencadas, V., PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications. Polymer Testing, 34, 64-71, 20140142-94180142-941810.1016/j.polymertesting.2013.12.007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:09:50Zoai:repositorium.sdum.uminho.pt:1822/31682Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:01:21.763788Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
spellingShingle PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
Fernandes, J. G.
Electrospun fibers
Drug release kinetics
Antibacterial activity
Biopolymers
Chlorhexidine
Science & Technology
title_short PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_full PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_fullStr PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_full_unstemmed PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_sort PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
author Fernandes, J. G.
author_facet Fernandes, J. G.
Correia, D. M.
Botelho, Gabriela
Padrão, Jorge
Dourado, Fernando
Ribeiro, C.
Lanceros-Méndez, S.
Sencadas, Vítor João Gomes Silva
author_role author
author2 Correia, D. M.
Botelho, Gabriela
Padrão, Jorge
Dourado, Fernando
Ribeiro, C.
Lanceros-Méndez, S.
Sencadas, Vítor João Gomes Silva
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fernandes, J. G.
Correia, D. M.
Botelho, Gabriela
Padrão, Jorge
Dourado, Fernando
Ribeiro, C.
Lanceros-Méndez, S.
Sencadas, Vítor João Gomes Silva
dc.subject.por.fl_str_mv Electrospun fibers
Drug release kinetics
Antibacterial activity
Biopolymers
Chlorhexidine
Science & Technology
topic Electrospun fibers
Drug release kinetics
Antibacterial activity
Biopolymers
Chlorhexidine
Science & Technology
description Fiber meshes of poly(hydroxybutyrate) (PHB) and poly(hydroxybutyrate)/poly(ethylene oxide) (PHB/PEO) with different concentrations of chlorhexidine (CHX) were prepared by electrospinning for assessment as a polymer based drug delivery system. The electrospun fibers were characterized at morphological, molecular and mechanical levels. The bactericidal potential of PHB and PHB/PEO electrospun fibers, with and without CHX, was investigated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by disk diffusion susceptibility tests. Electrospun fibers containing CHX exhibited bactericidal activity. PHB/PEO-1%CHX displayed higher CHX release levels and equivalent antibacterial activity when compared to PHB/PEO with 5 and 10 wt% CHX. Bactericidal performance of samples with 1 wt% CHX was assessed by Colony Forming Units (CFU), where reductions of 100% and 99.69% against E. coli and S. aureus were achieved, respectively.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/31682
url http://hdl.handle.net/1822/31682
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes, J. G.; Correia, D. M.; Botelho, G.; Padrão, J.; Dourado, Fernando; Ribeiro, C.; Lanceros-Méndez, S.; Sencadas, V., PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications. Polymer Testing, 34, 64-71, 2014
0142-9418
0142-9418
10.1016/j.polymertesting.2013.12.007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132411956559872

Registros relacionados