PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications

Detalhes bibliográficos
Autor(a) principal: Fernandes, J. G.
Data de Publicação: 2013
Outros Autores: Correia, D. M., Botelho, G., Padrão, J., Ribeiro, C., Lanceros-Mendez, S., Sencadas, V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/11110/611
Resumo: Fiber meshes of poly(hydroxybutyrate) (PHB) and poly(hydroxybutyrate)/ poly(ethylene oxide) (PHB/PEO) with different concentrations of chlorhexidine (CHX) were prepared by electrospinning, for assessment as a polymer based drug delivery system. The electrospun fibers were characterized at morphological, molecular and mechanical levels. The bactericidal potential of PHB and PHB/PEO electrospun fibers with and without CHX was investigated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by disk diffusion susceptibility tests. Electrospun fibers containing CHX exhibited bactericidal activity. PHB/PEO-1%CHX displayed higher CHX release levels and equivalent antibacterial activity when compared to PHB/PEO with 5 and 10 wt% CHX. Bactericidal performance of samples with 1 wt% CHX was assessed by Colony Forming Units (CFU), where a reduction of 100 % and 99.69 % against E. coli and S. aureus were achieved, respectively.
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spelling PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applicationsElectrospun fibersDrug release kineticsAntibacterial activityBiopolymersChlorhexidineFiber meshes of poly(hydroxybutyrate) (PHB) and poly(hydroxybutyrate)/ poly(ethylene oxide) (PHB/PEO) with different concentrations of chlorhexidine (CHX) were prepared by electrospinning, for assessment as a polymer based drug delivery system. The electrospun fibers were characterized at morphological, molecular and mechanical levels. The bactericidal potential of PHB and PHB/PEO electrospun fibers with and without CHX was investigated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by disk diffusion susceptibility tests. Electrospun fibers containing CHX exhibited bactericidal activity. PHB/PEO-1%CHX displayed higher CHX release levels and equivalent antibacterial activity when compared to PHB/PEO with 5 and 10 wt% CHX. Bactericidal performance of samples with 1 wt% CHX was assessed by Colony Forming Units (CFU), where a reduction of 100 % and 99.69 % against E. coli and S. aureus were achieved, respectively.This work was supported by FEDER through the COMPETE Program and by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Project PEST-C/FIS/UI607/2011 and PEST-C/QUI/UIO686/2011. The authors also thank funding from Matepro –Optimizing Materials and Processes”, ref. NORTE-07-0124-FEDER-000037”, co-funded by the “Programa Operacional Regional do Norte” (ON.2 – O Novo Norte), under the “Quadro de Referência Estratégico Nacional” (QREN), through the “Fundo Europeu de Desenvolvimento Regional” (FEDER). D.M.C, JP and VS thanks the FCT for the, SFRH/BD/ 82411/2011, SFRH/BD/64901/2009 and SFRH/BPD/63148/2009 grants respectively. The authors also thank support from the COST Action MP1003, 2010 ‘European Scientific Network for Artificial Muscles’ and to the COST Action MP1206 ‘Electrospun Nano-fibres for Bio inspired Composite Materials and Innovative Industrial Applications’. The authors also thank prof. José Luis Gomez Ribelles from the Unversidad Politécnica de Valencia, Spain, for interesting discussions on these issues.2014-02-04T19:05:46Z2014-02-04T19:05:46Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/11110/611oai:ciencipca.ipca.pt:11110/611eng0142-9418http://hdl.handle.net/11110/611Fernandes, J. G.Correia, D. M.Botelho, G.Padrão, J.Ribeiro, C.Lanceros-Mendez, S.Sencadas, V.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-05T12:52:11Zoai:ciencipca.ipca.pt:11110/611Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:01:04.434868Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
spellingShingle PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
Fernandes, J. G.
Electrospun fibers
Drug release kinetics
Antibacterial activity
Biopolymers
Chlorhexidine
title_short PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_full PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_fullStr PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_full_unstemmed PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
title_sort PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications
author Fernandes, J. G.
author_facet Fernandes, J. G.
Correia, D. M.
Botelho, G.
Padrão, J.
Ribeiro, C.
Lanceros-Mendez, S.
Sencadas, V.
author_role author
author2 Correia, D. M.
Botelho, G.
Padrão, J.
Ribeiro, C.
Lanceros-Mendez, S.
Sencadas, V.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, J. G.
Correia, D. M.
Botelho, G.
Padrão, J.
Ribeiro, C.
Lanceros-Mendez, S.
Sencadas, V.
dc.subject.por.fl_str_mv Electrospun fibers
Drug release kinetics
Antibacterial activity
Biopolymers
Chlorhexidine
topic Electrospun fibers
Drug release kinetics
Antibacterial activity
Biopolymers
Chlorhexidine
description Fiber meshes of poly(hydroxybutyrate) (PHB) and poly(hydroxybutyrate)/ poly(ethylene oxide) (PHB/PEO) with different concentrations of chlorhexidine (CHX) were prepared by electrospinning, for assessment as a polymer based drug delivery system. The electrospun fibers were characterized at morphological, molecular and mechanical levels. The bactericidal potential of PHB and PHB/PEO electrospun fibers with and without CHX was investigated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by disk diffusion susceptibility tests. Electrospun fibers containing CHX exhibited bactericidal activity. PHB/PEO-1%CHX displayed higher CHX release levels and equivalent antibacterial activity when compared to PHB/PEO with 5 and 10 wt% CHX. Bactericidal performance of samples with 1 wt% CHX was assessed by Colony Forming Units (CFU), where a reduction of 100 % and 99.69 % against E. coli and S. aureus were achieved, respectively.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01T00:00:00Z
2014-02-04T19:05:46Z
2014-02-04T19:05:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/11110/611
oai:ciencipca.ipca.pt:11110/611
url http://hdl.handle.net/11110/611
identifier_str_mv oai:ciencipca.ipca.pt:11110/611
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0142-9418
http://hdl.handle.net/11110/611
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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