Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://hdl.handle.net/1822/51555 |
Resumo: | uncorrected proof |
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Tau-dependent suppression of adult neurogenesis in the stressed hippocampusCiências Médicas::Medicina ClínicaScience & Technologyuncorrected proofStress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal function. Here, we analyzed the role of Tau on stress-driven suppression of neurogenesis in the adult dentate gyrus (DG) using animals lacking Tau (Tau-knockout; Tau-KO) and wild-type (WT) littermates. Unlike WTs, Tau-KO animals exposed to chronic stress did not exhibit reduction in DG proliferating cells, neuroblasts and newborn neurons; however, newborn astrocytes were similarly decreased in both Tau-KO and WT mice. In addition, chronic stress reduced phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)/glycogen synthase kinase-3 beta (GSK3 beta)/beta-catenin signaling, known to regulate cell survival and proliferation, in the DG of WT, but not Tau-KO, animals. These data establish Tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain.Portuguese Foundation for Science and Technology (FCT) Investigator grants (IF/01799/2013, IF/00883/2013, IF/01079/2014, respectively). This work was funded by FCT research grants 'PTDC/SAU-NMC/113934/2009' (IS), the Portuguese North Regional Operational Program (ON.2) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), the Project Estratégico co-funded by FCT (PEst-C/SAU/LA0026/2013) and the European Regional Development Fund COMPETE (FCOMP-01-0124-FEDER-037298) as well as the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER)info:eu-repo/semantics/publishedVersionNature Publishing GroupUniversidade do MinhoDioli, ChrysoulaPatrício, P.Trindade, R.Pinto, L. G.Silva, J. M.Morais, M.Ferreiro, E.Borges, S.Mateus-Pinheiro, A.Rodrigues, A. J.Sousa, NunoPeixoto, João Miguel Seiça BessaPinto, LuísaSotiropoulos, I.20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/51555engDioli, C., Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., … Sotiropoulos, I. (2017, May 30). Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular Psychiatry. Springer Science and Business Media LLC. http://doi.org/10.1038/mp.2017.1031359-418410.1038/mp.2017.10328555078https://www.nature.com/articles/mp2017103info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-08-03T01:22:37Zoai:repositorium.sdum.uminho.pt:1822/51555Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-08-03T01:22:37Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
| title |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
| spellingShingle |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus Dioli, Chrysoula Ciências Médicas::Medicina Clínica Science & Technology |
| title_short |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
| title_full |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
| title_fullStr |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
| title_full_unstemmed |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
| title_sort |
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus |
| author |
Dioli, Chrysoula |
| author_facet |
Dioli, Chrysoula Patrício, P. Trindade, R. Pinto, L. G. Silva, J. M. Morais, M. Ferreiro, E. Borges, S. Mateus-Pinheiro, A. Rodrigues, A. J. Sousa, Nuno Peixoto, João Miguel Seiça Bessa Pinto, Luísa Sotiropoulos, I. |
| author_role |
author |
| author2 |
Patrício, P. Trindade, R. Pinto, L. G. Silva, J. M. Morais, M. Ferreiro, E. Borges, S. Mateus-Pinheiro, A. Rodrigues, A. J. Sousa, Nuno Peixoto, João Miguel Seiça Bessa Pinto, Luísa Sotiropoulos, I. |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Dioli, Chrysoula Patrício, P. Trindade, R. Pinto, L. G. Silva, J. M. Morais, M. Ferreiro, E. Borges, S. Mateus-Pinheiro, A. Rodrigues, A. J. Sousa, Nuno Peixoto, João Miguel Seiça Bessa Pinto, Luísa Sotiropoulos, I. |
| dc.subject.por.fl_str_mv |
Ciências Médicas::Medicina Clínica Science & Technology |
| topic |
Ciências Médicas::Medicina Clínica Science & Technology |
| description |
uncorrected proof |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/51555 |
| url |
https://hdl.handle.net/1822/51555 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Dioli, C., Patrício, P., Trindade, R., Pinto, L. G., Silva, J. M., Morais, M., … Sotiropoulos, I. (2017, May 30). Tau-dependent suppression of adult neurogenesis in the stressed hippocampus. Molecular Psychiatry. Springer Science and Business Media LLC. http://doi.org/10.1038/mp.2017.103 1359-4184 10.1038/mp.2017.103 28555078 https://www.nature.com/articles/mp2017103 |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
| publisher.none.fl_str_mv |
Nature Publishing Group |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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1817544353876279296 |