A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97

Detalhes bibliográficos
Autor(a) principal: Ramalho-Carvalho, João
Data de Publicação: 2018
Outros Autores: Gonçalves, Celine Saraiva, Graça, Inês, Bidarra, David, Pereira-Silva, Eva, Salta, Sofia, Godinho, Maria Inês, Gomez, Antonio, Esteller, Manel, Costa, Bruno Marques, Henrique, Rui, Jerónimo, Carmen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/57931
Resumo: Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa.
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spelling A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97miR-152-3pProstate cancerCell cycleDNA methylationCRISPRTMEM97Ciências Médicas::Medicina BásicaScience & TechnologyProstate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa.Research Center of Portuguese Oncology Institute of Porto (FB-GEBC-27 and 19-CI-IPOP-2016). JR-C and CSG are supported by FCT- Fundação para a Ciência e Tecnologia PhD fellowships (SFRH/BD/71293/2010 and SFRH/BD/92786/2013), SS is supported by a PhD fellowship IPO/ESTIMA-1 NORTE-01-0145-FEDER-000027, and IG is a research fellow from the strategic funding of FCT (PCT: PEst- UID/DTP/00776/2013 and COMPETE: POCI-01-0145-FEDER-006868). BMC is funded by FCT-Fundação para a Ciência e a Tecnologia (IF/00601/2012)info:eu-repo/semantics/publishedVersionSpringer NatureUniversidade do MinhoRamalho-Carvalho, JoãoGonçalves, Celine SaraivaGraça, InêsBidarra, DavidPereira-Silva, EvaSalta, SofiaGodinho, Maria InêsGomez, AntonioEsteller, ManelCosta, Bruno MarquesHenrique, RuiJerónimo, Carmen20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57931engRamalho-Carvalho, J., Gonçalves, C. S., Graça, I., Bidarra, D., Pereira-Silva, E., Salta, S., ... & Henrique, R. (2018). A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Clinical epigenetics, 10(1), 401868-70751868-708310.1186/s13148-018-0475-229599847https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0475-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:42Zoai:repositorium.sdum.uminho.pt:1822/57931Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:43:35.526065Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
title A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
spellingShingle A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
Ramalho-Carvalho, João
miR-152-3p
Prostate cancer
Cell cycle
DNA methylation
CRISPR
TMEM97
Ciências Médicas::Medicina Básica
Science & Technology
title_short A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
title_full A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
title_fullStr A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
title_full_unstemmed A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
title_sort A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
author Ramalho-Carvalho, João
author_facet Ramalho-Carvalho, João
Gonçalves, Celine Saraiva
Graça, Inês
Bidarra, David
Pereira-Silva, Eva
Salta, Sofia
Godinho, Maria Inês
Gomez, Antonio
Esteller, Manel
Costa, Bruno Marques
Henrique, Rui
Jerónimo, Carmen
author_role author
author2 Gonçalves, Celine Saraiva
Graça, Inês
Bidarra, David
Pereira-Silva, Eva
Salta, Sofia
Godinho, Maria Inês
Gomez, Antonio
Esteller, Manel
Costa, Bruno Marques
Henrique, Rui
Jerónimo, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ramalho-Carvalho, João
Gonçalves, Celine Saraiva
Graça, Inês
Bidarra, David
Pereira-Silva, Eva
Salta, Sofia
Godinho, Maria Inês
Gomez, Antonio
Esteller, Manel
Costa, Bruno Marques
Henrique, Rui
Jerónimo, Carmen
dc.subject.por.fl_str_mv miR-152-3p
Prostate cancer
Cell cycle
DNA methylation
CRISPR
TMEM97
Ciências Médicas::Medicina Básica
Science & Technology
topic miR-152-3p
Prostate cancer
Cell cycle
DNA methylation
CRISPR
TMEM97
Ciências Médicas::Medicina Básica
Science & Technology
description Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/57931
url http://hdl.handle.net/1822/57931
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ramalho-Carvalho, J., Gonçalves, C. S., Graça, I., Bidarra, D., Pereira-Silva, E., Salta, S., ... & Henrique, R. (2018). A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Clinical epigenetics, 10(1), 40
1868-7075
1868-7083
10.1186/s13148-018-0475-2
29599847
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0475-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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