A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/57931 |
Resumo: | Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa. |
id |
RCAP_7e56556e0dafb64862a64435701992a6 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/57931 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97miR-152-3pProstate cancerCell cycleDNA methylationCRISPRTMEM97Ciências Médicas::Medicina BásicaScience & TechnologyProstate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa.Research Center of Portuguese Oncology Institute of Porto (FB-GEBC-27 and 19-CI-IPOP-2016). JR-C and CSG are supported by FCT- Fundação para a Ciência e Tecnologia PhD fellowships (SFRH/BD/71293/2010 and SFRH/BD/92786/2013), SS is supported by a PhD fellowship IPO/ESTIMA-1 NORTE-01-0145-FEDER-000027, and IG is a research fellow from the strategic funding of FCT (PCT: PEst- UID/DTP/00776/2013 and COMPETE: POCI-01-0145-FEDER-006868). BMC is funded by FCT-Fundação para a Ciência e a Tecnologia (IF/00601/2012)info:eu-repo/semantics/publishedVersionSpringer NatureUniversidade do MinhoRamalho-Carvalho, JoãoGonçalves, Celine SaraivaGraça, InêsBidarra, DavidPereira-Silva, EvaSalta, SofiaGodinho, Maria InêsGomez, AntonioEsteller, ManelCosta, Bruno MarquesHenrique, RuiJerónimo, Carmen20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57931engRamalho-Carvalho, J., Gonçalves, C. S., Graça, I., Bidarra, D., Pereira-Silva, E., Salta, S., ... & Henrique, R. (2018). A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Clinical epigenetics, 10(1), 401868-70751868-708310.1186/s13148-018-0475-229599847https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0475-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:42Zoai:repositorium.sdum.uminho.pt:1822/57931Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:43:35.526065Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
title |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
spellingShingle |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 Ramalho-Carvalho, João miR-152-3p Prostate cancer Cell cycle DNA methylation CRISPR TMEM97 Ciências Médicas::Medicina Básica Science & Technology |
title_short |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
title_full |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
title_fullStr |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
title_full_unstemmed |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
title_sort |
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 |
author |
Ramalho-Carvalho, João |
author_facet |
Ramalho-Carvalho, João Gonçalves, Celine Saraiva Graça, Inês Bidarra, David Pereira-Silva, Eva Salta, Sofia Godinho, Maria Inês Gomez, Antonio Esteller, Manel Costa, Bruno Marques Henrique, Rui Jerónimo, Carmen |
author_role |
author |
author2 |
Gonçalves, Celine Saraiva Graça, Inês Bidarra, David Pereira-Silva, Eva Salta, Sofia Godinho, Maria Inês Gomez, Antonio Esteller, Manel Costa, Bruno Marques Henrique, Rui Jerónimo, Carmen |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ramalho-Carvalho, João Gonçalves, Celine Saraiva Graça, Inês Bidarra, David Pereira-Silva, Eva Salta, Sofia Godinho, Maria Inês Gomez, Antonio Esteller, Manel Costa, Bruno Marques Henrique, Rui Jerónimo, Carmen |
dc.subject.por.fl_str_mv |
miR-152-3p Prostate cancer Cell cycle DNA methylation CRISPR TMEM97 Ciências Médicas::Medicina Básica Science & Technology |
topic |
miR-152-3p Prostate cancer Cell cycle DNA methylation CRISPR TMEM97 Ciências Médicas::Medicina Básica Science & Technology |
description |
Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/57931 |
url |
http://hdl.handle.net/1822/57931 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ramalho-Carvalho, J., Gonçalves, C. S., Graça, I., Bidarra, D., Pereira-Silva, E., Salta, S., ... & Henrique, R. (2018). A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Clinical epigenetics, 10(1), 40 1868-7075 1868-7083 10.1186/s13148-018-0475-2 29599847 https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-018-0475-2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132993235714048 |