Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/14928 |
Resumo: | Neuronal surface autoantibodies (NSAbs) against various antigens cause autoimmune encephalitis. Some of these antigens are also involved in the pathology of depression and anxiety. To study whether NSAbs are more common in plasma of individuals with depression and anxiety than in controls, and to investigate if NSAbs correlate with disease status, plasma samples of 819 individuals with a current diagnosis of depression and/or anxiety, 920 in remission and 492 individuals without these disorders were included in this study. Samples were tested by a combination of immunohistochemistry (IHC), staining on live rat hippocampus neurons and cell-based assay (CBA). By IHC, 50 (2.2%) samples showed immunoreactivity to rat brain tissue, with no significant differences between the aforementioned groups (22/819 vs 18/920 vs 11/492, P > 0.99). In addition, eight IHC positive samples were positive for NSAbs on live neurons (7/819 vs 0/920 vs 1/492, P = 0.006). The IHC-staining patterns of these eight samples were atypical for autoimmune encephalitis and accordingly, they tested negative for known NSAbs by CBA. No obvious difference in the clinical characteristics between individuals with or without NSAbs was observed. In conclusion, novel NSAbs were rare but predominately found in patients with current anxiety or depression indicating they might affect mental health in a small group of patients. |
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Novel neuronal surface autoantibodies in plasma of patients with depression and anxietyReceptor antibodiesPrevalence;EncephalitisDisorderSchizophreniaNeuronal surface autoantibodies (NSAbs) against various antigens cause autoimmune encephalitis. Some of these antigens are also involved in the pathology of depression and anxiety. To study whether NSAbs are more common in plasma of individuals with depression and anxiety than in controls, and to investigate if NSAbs correlate with disease status, plasma samples of 819 individuals with a current diagnosis of depression and/or anxiety, 920 in remission and 492 individuals without these disorders were included in this study. Samples were tested by a combination of immunohistochemistry (IHC), staining on live rat hippocampus neurons and cell-based assay (CBA). By IHC, 50 (2.2%) samples showed immunoreactivity to rat brain tissue, with no significant differences between the aforementioned groups (22/819 vs 18/920 vs 11/492, P > 0.99). In addition, eight IHC positive samples were positive for NSAbs on live neurons (7/819 vs 0/920 vs 1/492, P = 0.006). The IHC-staining patterns of these eight samples were atypical for autoimmune encephalitis and accordingly, they tested negative for known NSAbs by CBA. No obvious difference in the clinical characteristics between individuals with or without NSAbs was observed. In conclusion, novel NSAbs were rare but predominately found in patients with current anxiety or depression indicating they might affect mental health in a small group of patients.Springer NatureSapientiaZong, ShenghuaHoffmann, Carolin CorreiaMané-Damas, MarinaKappelmann, NilsMolenaar, Peter C.van Grootheest, GerardPenninx, Brenda W. J. H.Rouhl, Rob P. W.Losen, MarioMartinez-Martinez, Pilar2020-12-18T20:46:58Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/14928eng2158-318810.1038/s41398-020-01083-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:27:16Zoai:sapientia.ualg.pt:10400.1/14928Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:05:51.917431Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety |
title |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety |
spellingShingle |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety Zong, Shenghua Receptor antibodies Prevalence; Encephalitis Disorder Schizophrenia |
title_short |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety |
title_full |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety |
title_fullStr |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety |
title_full_unstemmed |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety |
title_sort |
Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety |
author |
Zong, Shenghua |
author_facet |
Zong, Shenghua Hoffmann, Carolin Correia Mané-Damas, Marina Kappelmann, Nils Molenaar, Peter C. van Grootheest, Gerard Penninx, Brenda W. J. H. Rouhl, Rob P. W. Losen, Mario Martinez-Martinez, Pilar |
author_role |
author |
author2 |
Hoffmann, Carolin Correia Mané-Damas, Marina Kappelmann, Nils Molenaar, Peter C. van Grootheest, Gerard Penninx, Brenda W. J. H. Rouhl, Rob P. W. Losen, Mario Martinez-Martinez, Pilar |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Zong, Shenghua Hoffmann, Carolin Correia Mané-Damas, Marina Kappelmann, Nils Molenaar, Peter C. van Grootheest, Gerard Penninx, Brenda W. J. H. Rouhl, Rob P. W. Losen, Mario Martinez-Martinez, Pilar |
dc.subject.por.fl_str_mv |
Receptor antibodies Prevalence; Encephalitis Disorder Schizophrenia |
topic |
Receptor antibodies Prevalence; Encephalitis Disorder Schizophrenia |
description |
Neuronal surface autoantibodies (NSAbs) against various antigens cause autoimmune encephalitis. Some of these antigens are also involved in the pathology of depression and anxiety. To study whether NSAbs are more common in plasma of individuals with depression and anxiety than in controls, and to investigate if NSAbs correlate with disease status, plasma samples of 819 individuals with a current diagnosis of depression and/or anxiety, 920 in remission and 492 individuals without these disorders were included in this study. Samples were tested by a combination of immunohistochemistry (IHC), staining on live rat hippocampus neurons and cell-based assay (CBA). By IHC, 50 (2.2%) samples showed immunoreactivity to rat brain tissue, with no significant differences between the aforementioned groups (22/819 vs 18/920 vs 11/492, P > 0.99). In addition, eight IHC positive samples were positive for NSAbs on live neurons (7/819 vs 0/920 vs 1/492, P = 0.006). The IHC-staining patterns of these eight samples were atypical for autoimmune encephalitis and accordingly, they tested negative for known NSAbs by CBA. No obvious difference in the clinical characteristics between individuals with or without NSAbs was observed. In conclusion, novel NSAbs were rare but predominately found in patients with current anxiety or depression indicating they might affect mental health in a small group of patients. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-18T20:46:58Z 2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/14928 |
url |
http://hdl.handle.net/10400.1/14928 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2158-3188 10.1038/s41398-020-01083-y |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133298864160768 |