Design and performance assessment of a solid-state microcooler for thermal neuromodulation
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/59988 |
Resumo: | It is well known that neural activity can be modulated using a cooling device. The applications of this technique range from the treatment of medication-resistant cerebral diseases to brain functional mapping. Despite the potential benefits of such technique, its use has been limited due to the lack of suitable thermal modulators. This paper presents the design and validation of a solid-state cooler that was able to modulate the neural activity of rodents without the use of large and unpractical water pipes. A miniaturized thermal control solution based exclusively on solid-state devices was designed, occupying only 5 mm × 5 mm × 3 mm, and featuring the potential for wireless power and communications. The cold side of the device was cooled to 26 °C, while the hot side was kept below 43 °C. This range of temperatures is compatible with brain cooling and efficient enough for achieving some control of neural activity. |
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Design and performance assessment of a solid-state microcooler for thermal neuromodulationsolid-state coolingmicrosystem integrationthermal simulationthermal neuromodulationmicrodevice packagingbiomedical microdeviceneuronalimplantableScience & TechnologyIt is well known that neural activity can be modulated using a cooling device. The applications of this technique range from the treatment of medication-resistant cerebral diseases to brain functional mapping. Despite the potential benefits of such technique, its use has been limited due to the lack of suitable thermal modulators. This paper presents the design and validation of a solid-state cooler that was able to modulate the neural activity of rodents without the use of large and unpractical water pipes. A miniaturized thermal control solution based exclusively on solid-state devices was designed, occupying only 5 mm × 5 mm × 3 mm, and featuring the potential for wireless power and communications. The cold side of the device was cooled to 26 °C, while the hot side was kept below 43 °C. This range of temperatures is compatible with brain cooling and efficient enough for achieving some control of neural activity.This work is supported by Foundation for Science and Technology (FCT) with the reference project PTDC/EEI-TEL/5250/2014, by FEDER funds through Projecto 3599 - Promover a Produção Científica e Desenvolvimento Tecnológico e a Constituição de Redes Temáticas (3599-PPCDT) and by grant SFRH/BD/100649/2014.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoFernandes, JoséVendramini, EstelleMiranda, Ana M.Silva, CristianaDinis, HugoCoizet, VeroniqueDavid, OlivierMendes, P. M.2018-01-272018-01-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/59988eng2072-666X10.3390/mi9020047info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:28:42Zoai:repositorium.sdum.uminho.pt:1822/59988Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:23:33.209795Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation |
title |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation |
spellingShingle |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation Fernandes, José solid-state cooling microsystem integration thermal simulation thermal neuromodulation microdevice packaging biomedical microdevice neuronal implantable Science & Technology |
title_short |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation |
title_full |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation |
title_fullStr |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation |
title_full_unstemmed |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation |
title_sort |
Design and performance assessment of a solid-state microcooler for thermal neuromodulation |
author |
Fernandes, José |
author_facet |
Fernandes, José Vendramini, Estelle Miranda, Ana M. Silva, Cristiana Dinis, Hugo Coizet, Veronique David, Olivier Mendes, P. M. |
author_role |
author |
author2 |
Vendramini, Estelle Miranda, Ana M. Silva, Cristiana Dinis, Hugo Coizet, Veronique David, Olivier Mendes, P. M. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Fernandes, José Vendramini, Estelle Miranda, Ana M. Silva, Cristiana Dinis, Hugo Coizet, Veronique David, Olivier Mendes, P. M. |
dc.subject.por.fl_str_mv |
solid-state cooling microsystem integration thermal simulation thermal neuromodulation microdevice packaging biomedical microdevice neuronal implantable Science & Technology |
topic |
solid-state cooling microsystem integration thermal simulation thermal neuromodulation microdevice packaging biomedical microdevice neuronal implantable Science & Technology |
description |
It is well known that neural activity can be modulated using a cooling device. The applications of this technique range from the treatment of medication-resistant cerebral diseases to brain functional mapping. Despite the potential benefits of such technique, its use has been limited due to the lack of suitable thermal modulators. This paper presents the design and validation of a solid-state cooler that was able to modulate the neural activity of rodents without the use of large and unpractical water pipes. A miniaturized thermal control solution based exclusively on solid-state devices was designed, occupying only 5 mm × 5 mm × 3 mm, and featuring the potential for wireless power and communications. The cold side of the device was cooled to 26 °C, while the hot side was kept below 43 °C. This range of temperatures is compatible with brain cooling and efficient enough for achieving some control of neural activity. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-27 2018-01-27T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/59988 |
url |
http://hdl.handle.net/1822/59988 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2072-666X 10.3390/mi9020047 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132710510264320 |