Brain dysfunction in tubular and tubulointerstitial kidney diseases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/131651 |
Resumo: | Funding: This article is published as part of a supplement financially supported by the COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Brain dysfunction in tubular and tubulointerstitial kidney diseasesbrainchronic kidney diseasecognitive functionelectrolytetubulointerstitialNephrologyTransplantationSDG 3 - Good Health and Well-beingFunding: This article is published as part of a supplement financially supported by the COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT).Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria, predominant tubular injury, with or without tubulointerstitial disease, is typically non-proteinuric. CKD has been linked with cognitive impairment, but it is unclear how much this depends on a decreased GFR, altered tubular function or the presence of proteinuria. Since CKD is often accompanied by tubular and interstitial dysfunction, we explore here for the first time the potential role of the tubular and tubulointerstitial compartments in cognitive dysfunction. To help address this issue we selected a group of primary tubular diseases with preserved GFR in which to review the evidence for any association with brain dysfunction. Cognition, mood, neurosensory and motor disturbances are not well characterized in tubular diseases, possibly because they are subclinical and less prominent than other clinical manifestations. The available literature suggests that brain dysfunction in tubular and tubulointerstitial diseases is usually mild and is more often seen in disorders of water handling. Brain dysfunction may occur when severe electrolyte and water disorders in young children persist over a long period of time before the diagnosis is made. We have chosen Bartter and Gitelman syndromes and nephrogenic diabetes insipidus as examples to highlight this topic. We discuss current published findings, some unanswered questions and propose topics for future research.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNViggiano, DavideBruchfeld, AnnetteCarriazo, Solde Donato, AntonioEndlich, NicoleFerreira, Ana CarinaFigurek, AndrejaFouque, DenisFranssen, Casper F.M.Giannakou, KonstantinosGoumenos, DimitriosHoorn, Ewout J.Nitsch, DorotheaOrtiz, AlbertoPešić, VesnaRastenyté, DaivaSoler, Maria JoséRroji, MeritaTrepiccione, FrancescoUnwin, Robert J.Wagner, Carsten A.Wieçek, AndrzejZacchia, MiriamZoccali, CarmineCapasso, Giovambattista2022-01-27T03:27:12Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/131651eng0931-0509PURE: 36396517https://doi.org/10.1093/ndt/gfab276info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:10:16Zoai:run.unl.pt:10362/131651Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:09.366044Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Brain dysfunction in tubular and tubulointerstitial kidney diseases |
| title |
Brain dysfunction in tubular and tubulointerstitial kidney diseases |
| spellingShingle |
Brain dysfunction in tubular and tubulointerstitial kidney diseases Viggiano, Davide brain chronic kidney disease cognitive function electrolyte tubulointerstitial Nephrology Transplantation SDG 3 - Good Health and Well-being |
| title_short |
Brain dysfunction in tubular and tubulointerstitial kidney diseases |
| title_full |
Brain dysfunction in tubular and tubulointerstitial kidney diseases |
| title_fullStr |
Brain dysfunction in tubular and tubulointerstitial kidney diseases |
| title_full_unstemmed |
Brain dysfunction in tubular and tubulointerstitial kidney diseases |
| title_sort |
Brain dysfunction in tubular and tubulointerstitial kidney diseases |
| author |
Viggiano, Davide |
| author_facet |
Viggiano, Davide Bruchfeld, Annette Carriazo, Sol de Donato, Antonio Endlich, Nicole Ferreira, Ana Carina Figurek, Andreja Fouque, Denis Franssen, Casper F.M. Giannakou, Konstantinos Goumenos, Dimitrios Hoorn, Ewout J. Nitsch, Dorothea Ortiz, Alberto Pešić, Vesna Rastenyté, Daiva Soler, Maria José Rroji, Merita Trepiccione, Francesco Unwin, Robert J. Wagner, Carsten A. Wieçek, Andrzej Zacchia, Miriam Zoccali, Carmine Capasso, Giovambattista |
| author_role |
author |
| author2 |
Bruchfeld, Annette Carriazo, Sol de Donato, Antonio Endlich, Nicole Ferreira, Ana Carina Figurek, Andreja Fouque, Denis Franssen, Casper F.M. Giannakou, Konstantinos Goumenos, Dimitrios Hoorn, Ewout J. Nitsch, Dorothea Ortiz, Alberto Pešić, Vesna Rastenyté, Daiva Soler, Maria José Rroji, Merita Trepiccione, Francesco Unwin, Robert J. Wagner, Carsten A. Wieçek, Andrzej Zacchia, Miriam Zoccali, Carmine Capasso, Giovambattista |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Viggiano, Davide Bruchfeld, Annette Carriazo, Sol de Donato, Antonio Endlich, Nicole Ferreira, Ana Carina Figurek, Andreja Fouque, Denis Franssen, Casper F.M. Giannakou, Konstantinos Goumenos, Dimitrios Hoorn, Ewout J. Nitsch, Dorothea Ortiz, Alberto Pešić, Vesna Rastenyté, Daiva Soler, Maria José Rroji, Merita Trepiccione, Francesco Unwin, Robert J. Wagner, Carsten A. Wieçek, Andrzej Zacchia, Miriam Zoccali, Carmine Capasso, Giovambattista |
| dc.subject.por.fl_str_mv |
brain chronic kidney disease cognitive function electrolyte tubulointerstitial Nephrology Transplantation SDG 3 - Good Health and Well-being |
| topic |
brain chronic kidney disease cognitive function electrolyte tubulointerstitial Nephrology Transplantation SDG 3 - Good Health and Well-being |
| description |
Funding: This article is published as part of a supplement financially supported by the COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-01-27T03:27:12Z 2022-01 2022-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/131651 |
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http://hdl.handle.net/10362/131651 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0931-0509 PURE: 36396517 https://doi.org/10.1093/ndt/gfab276 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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