Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2140 |
Resumo: | Background: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in Portugal. |
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Idiopathic Hypocomplementaemic Tubulointerstitial NephritisNefrite Túbulo-Intersticial Hipocomplementémica IdiopáticaHCC NEFHCC MEDRenal Failure, ChronicNephritis, TubulointerstitialBackground: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in Portugal.Sociedade Portuguesa de NefrologiaRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEAzevedo, AMesquita, IViana, HRocha, GFerreira, CFernandes, VMurinello, ACarvalho, FNolasco, F2015-04-29T10:33:05Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2140engPort J Nephrol Hypert 2015; 29 (1): 71-77info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:35:10Zoai:repositorio.chlc.min-saude.pt:10400.17/2140Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:31.638639Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis Nefrite Túbulo-Intersticial Hipocomplementémica Idiopática |
title |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis |
spellingShingle |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis Azevedo, A HCC NEF HCC MED Renal Failure, Chronic Nephritis, Tubulointerstitial |
title_short |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis |
title_full |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis |
title_fullStr |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis |
title_full_unstemmed |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis |
title_sort |
Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis |
author |
Azevedo, A |
author_facet |
Azevedo, A Mesquita, I Viana, H Rocha, G Ferreira, C Fernandes, V Murinello, A Carvalho, F Nolasco, F |
author_role |
author |
author2 |
Mesquita, I Viana, H Rocha, G Ferreira, C Fernandes, V Murinello, A Carvalho, F Nolasco, F |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Azevedo, A Mesquita, I Viana, H Rocha, G Ferreira, C Fernandes, V Murinello, A Carvalho, F Nolasco, F |
dc.subject.por.fl_str_mv |
HCC NEF HCC MED Renal Failure, Chronic Nephritis, Tubulointerstitial |
topic |
HCC NEF HCC MED Renal Failure, Chronic Nephritis, Tubulointerstitial |
description |
Background: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in Portugal. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-29T10:33:05Z 2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2140 |
url |
http://hdl.handle.net/10400.17/2140 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Port J Nephrol Hypert 2015; 29 (1): 71-77 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799131292169666560 |