Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Detalhes bibliográficos
Autor(a) principal: Doglio, Matteo
Data de Publicação: 2022
Outros Autores: Crossland, Rachel E., Alho, Ana Cristina, Penack, Olaf, Dickinson, Anne M., Stary, Georg, Lacerda, João, Eissner, Günther, Inngjerdingen, Marit
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56198
Resumo: Copyright © 2022 Doglio, Crossland, Alho, Penack, Dickinson, Stary, Lacerda, Eissner and Inngjerdingen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host diseaseCARILCsMSCsNK cellsTregsChronic GVHDExtracellular vesiclesCopyright © 2022 Doglio, Crossland, Alho, Penack, Dickinson, Stary, Lacerda, Eissner and Inngjerdingen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies. However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory complications can occur, among which chronic graft-versus-host disease (cGVHD) can be life-threatening. A classical therapeutic approach to the prevention and treatment of cGVHD has been broad immunosuppression, but more recently adjuvant immunotherapies have been tested. This review summarizes and discusses immunomodulatory approaches with T cells, including chimeric antigen receptor (CAR) and regulatory T cells, with natural killer (NK) cells and innate lymphoid cells (ILCs), and finally with mesenchymal stromal cells (MSC) and extracellular vesicles thereof. Clinical studies and pre-clinical research results are presented likewise.This work was supported by COST (European Cooperation in Science and Technology). www.cost.eu - COST Action 17138 EUROGRAFT.FrontiersRepositório da Universidade de LisboaDoglio, MatteoCrossland, Rachel E.Alho, Ana CristinaPenack, OlafDickinson, Anne M.Stary, GeorgLacerda, JoãoEissner, GüntherInngjerdingen, Marit2023-02-07T12:24:00Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56198engFront Immunol. 2022 Nov 17;13:104516810.3389/fimmu.2022.10451681664-3224info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:03:37Zoai:repositorio.ul.pt:10451/56198Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:43.576820Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
title Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
spellingShingle Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
Doglio, Matteo
CAR
ILCs
MSCs
NK cells
Tregs
Chronic GVHD
Extracellular vesicles
title_short Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
title_full Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
title_fullStr Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
title_full_unstemmed Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
title_sort Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
author Doglio, Matteo
author_facet Doglio, Matteo
Crossland, Rachel E.
Alho, Ana Cristina
Penack, Olaf
Dickinson, Anne M.
Stary, Georg
Lacerda, João
Eissner, Günther
Inngjerdingen, Marit
author_role author
author2 Crossland, Rachel E.
Alho, Ana Cristina
Penack, Olaf
Dickinson, Anne M.
Stary, Georg
Lacerda, João
Eissner, Günther
Inngjerdingen, Marit
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Doglio, Matteo
Crossland, Rachel E.
Alho, Ana Cristina
Penack, Olaf
Dickinson, Anne M.
Stary, Georg
Lacerda, João
Eissner, Günther
Inngjerdingen, Marit
dc.subject.por.fl_str_mv CAR
ILCs
MSCs
NK cells
Tregs
Chronic GVHD
Extracellular vesicles
topic CAR
ILCs
MSCs
NK cells
Tregs
Chronic GVHD
Extracellular vesicles
description Copyright © 2022 Doglio, Crossland, Alho, Penack, Dickinson, Stary, Lacerda, Eissner and Inngjerdingen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-02-07T12:24:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56198
url http://hdl.handle.net/10451/56198
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Immunol. 2022 Nov 17;13:1045168
10.3389/fimmu.2022.1045168
1664-3224
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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