In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/64424 |
Resumo: | Recently, some species of the genus Flourensia have been identified by their potential health effects (e.g. anti-inflammatory and apoptotic). Encapsulation of plant extracts is a process that can allow an adequate dosage administration, as well as to protect bioactive compounds and improve their controlled release in the gastrointestinal (GI) system. Therefore, the aims of this work were: to microencapsulate the ethanol extracts of F. cernua, F. microphylla, and F. retinophylla; and to evaluate the controlled release of the microencapsuled extracts in an in vitro GI system. Leaves of Flourensia spp. were collected in wild sites of Coahuila State, and the ethanol extracts were obtained by the Soxhlet method. The encapsulation was performed by the gelation technique, using alginate. The microcapsules formed were characterized in terms of total phenol content (Folin-Ciocalteu method), antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic) diammonium acid (ABTS), and the ferric reducing antioxidant power (FRAP) assays, scanning electron microscopy (SEM), and thermal analysis, and in vitro GI digestion. The microcapsules were found to have spherical-shape and a micro-scale dimension in the range of 2.168.8??m. Also, the built of microcapsules was confirmed by the appearance of an exothermic peak centered at 600?°C in the DSC analysis. F. microphylla noted for its strong antioxidant activity, even in its encapsulated form. In the gastric system the extracts of fresh microcapsules were released from 7.7% to 14.5%, while values of 26.5% to 53.3% were observed for those dried. For the intestinal system, the higher release was observed for dried microcapsules (59.9% to 78.4%) than for those fresh (26.3% to 30.2%). Thus, it was demonstrated that the alginate microcapsule protected the extracts until they were delivered to the target site in the GI model, and this effect was better with the dried microcapsules of Flourensia spp. This study would set the guide for the application of Flourensia spp. extracts in order to take advantage of their benefits to human health. |
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In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophyllaMicrocapsulesGastrointestinal digestionControlled releaseF. cernuaF. microphyllaF. retinophyllaScience & TechnologyRecently, some species of the genus Flourensia have been identified by their potential health effects (e.g. anti-inflammatory and apoptotic). Encapsulation of plant extracts is a process that can allow an adequate dosage administration, as well as to protect bioactive compounds and improve their controlled release in the gastrointestinal (GI) system. Therefore, the aims of this work were: to microencapsulate the ethanol extracts of F. cernua, F. microphylla, and F. retinophylla; and to evaluate the controlled release of the microencapsuled extracts in an in vitro GI system. Leaves of Flourensia spp. were collected in wild sites of Coahuila State, and the ethanol extracts were obtained by the Soxhlet method. The encapsulation was performed by the gelation technique, using alginate. The microcapsules formed were characterized in terms of total phenol content (Folin-Ciocalteu method), antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic) diammonium acid (ABTS), and the ferric reducing antioxidant power (FRAP) assays, scanning electron microscopy (SEM), and thermal analysis, and in vitro GI digestion. The microcapsules were found to have spherical-shape and a micro-scale dimension in the range of 2.168.8??m. Also, the built of microcapsules was confirmed by the appearance of an exothermic peak centered at 600?°C in the DSC analysis. F. microphylla noted for its strong antioxidant activity, even in its encapsulated form. In the gastric system the extracts of fresh microcapsules were released from 7.7% to 14.5%, while values of 26.5% to 53.3% were observed for those dried. For the intestinal system, the higher release was observed for dried microcapsules (59.9% to 78.4%) than for those fresh (26.3% to 30.2%). Thus, it was demonstrated that the alginate microcapsule protected the extracts until they were delivered to the target site in the GI model, and this effect was better with the dried microcapsules of Flourensia spp. This study would set the guide for the application of Flourensia spp. extracts in order to take advantage of their benefits to human health.Author G.N. Puente Romero thanks Mexican Science and Technology Council (CONACYT, Mexico) for MSc fellowship support. Authors would like to thank to María Guadalupe Moreno Esquivel, Edith E. Chaires Colunga, Olga L. Solís Hernández, and M. Leticia Rodríguez González of the Phytochemistry Laboratory from Universidad Autónoma Agraria Antonio Narro, for their support in the lab experiments.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoRodríguez, D. Jasso dePuente-Romero, G. N.Díaz-Jiménez, L.Rodríguez-García, R.Ramírez-Rodríguez, H.Villarreal-Quintanilla, J. A.López, M.Carrillo-Lomelí, D. A.Genisheva, Zlatina2019-10-052019-10-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/64424engRodríguez, D. Jasso de; Puente-Romero, G. N.; Díaz-Jiménez, L.; Rodríguez-García, R.; Ramírez-Rodríguez, H.; Villarreal-Quintanilla, J. A.; López, M.; Carrillo-Lomelí, D. A.; Genisheva, Zlatina, In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla. Industrial Crops and Products, 138(111444), 20190926-66901872-633X10.1016/j.indcrop.2019.06.007http://www.elsevier.com/locate/issn/09266690info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:17:20Zoai:repositorium.sdum.uminho.pt:1822/64424Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:09:57.434352Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla |
title |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla |
spellingShingle |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla Rodríguez, D. Jasso de Microcapsules Gastrointestinal digestion Controlled release F. cernua F. microphylla F. retinophylla Science & Technology |
title_short |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla |
title_full |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla |
title_fullStr |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla |
title_full_unstemmed |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla |
title_sort |
In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla |
author |
Rodríguez, D. Jasso de |
author_facet |
Rodríguez, D. Jasso de Puente-Romero, G. N. Díaz-Jiménez, L. Rodríguez-García, R. Ramírez-Rodríguez, H. Villarreal-Quintanilla, J. A. López, M. Carrillo-Lomelí, D. A. Genisheva, Zlatina |
author_role |
author |
author2 |
Puente-Romero, G. N. Díaz-Jiménez, L. Rodríguez-García, R. Ramírez-Rodríguez, H. Villarreal-Quintanilla, J. A. López, M. Carrillo-Lomelí, D. A. Genisheva, Zlatina |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rodríguez, D. Jasso de Puente-Romero, G. N. Díaz-Jiménez, L. Rodríguez-García, R. Ramírez-Rodríguez, H. Villarreal-Quintanilla, J. A. López, M. Carrillo-Lomelí, D. A. Genisheva, Zlatina |
dc.subject.por.fl_str_mv |
Microcapsules Gastrointestinal digestion Controlled release F. cernua F. microphylla F. retinophylla Science & Technology |
topic |
Microcapsules Gastrointestinal digestion Controlled release F. cernua F. microphylla F. retinophylla Science & Technology |
description |
Recently, some species of the genus Flourensia have been identified by their potential health effects (e.g. anti-inflammatory and apoptotic). Encapsulation of plant extracts is a process that can allow an adequate dosage administration, as well as to protect bioactive compounds and improve their controlled release in the gastrointestinal (GI) system. Therefore, the aims of this work were: to microencapsulate the ethanol extracts of F. cernua, F. microphylla, and F. retinophylla; and to evaluate the controlled release of the microencapsuled extracts in an in vitro GI system. Leaves of Flourensia spp. were collected in wild sites of Coahuila State, and the ethanol extracts were obtained by the Soxhlet method. The encapsulation was performed by the gelation technique, using alginate. The microcapsules formed were characterized in terms of total phenol content (Folin-Ciocalteu method), antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic) diammonium acid (ABTS), and the ferric reducing antioxidant power (FRAP) assays, scanning electron microscopy (SEM), and thermal analysis, and in vitro GI digestion. The microcapsules were found to have spherical-shape and a micro-scale dimension in the range of 2.168.8??m. Also, the built of microcapsules was confirmed by the appearance of an exothermic peak centered at 600?°C in the DSC analysis. F. microphylla noted for its strong antioxidant activity, even in its encapsulated form. In the gastric system the extracts of fresh microcapsules were released from 7.7% to 14.5%, while values of 26.5% to 53.3% were observed for those dried. For the intestinal system, the higher release was observed for dried microcapsules (59.9% to 78.4%) than for those fresh (26.3% to 30.2%). Thus, it was demonstrated that the alginate microcapsule protected the extracts until they were delivered to the target site in the GI model, and this effect was better with the dried microcapsules of Flourensia spp. This study would set the guide for the application of Flourensia spp. extracts in order to take advantage of their benefits to human health. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-05 2019-10-05T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/64424 |
url |
http://hdl.handle.net/1822/64424 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rodríguez, D. Jasso de; Puente-Romero, G. N.; Díaz-Jiménez, L.; Rodríguez-García, R.; Ramírez-Rodríguez, H.; Villarreal-Quintanilla, J. A.; López, M.; Carrillo-Lomelí, D. A.; Genisheva, Zlatina, In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla. Industrial Crops and Products, 138(111444), 2019 0926-6690 1872-633X 10.1016/j.indcrop.2019.06.007 http://www.elsevier.com/locate/issn/09266690 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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