Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/164567 |
Resumo: | Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Dopamine neuron activity encodes the length of upcoming contralateral movement sequencesCopyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.Dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement speed, and loss of these neurons leads to bradykinesia in Parkinson's disease (PD). However, other aspects of movement vigor are also affected in PD; for example, movement sequences are typically shorter. However, the relationship between the activity of DANs and the length of movement sequences is unknown. We imaged activity of SNc DANs in mice trained in a freely moving operant task, which relies on individual forelimb sequences. We uncovered a similar proportion of SNc DANs increasing their activity before either ipsilateral or contralateral sequences. However, the magnitude of this activity was higher for contralateral actions and was related to contralateral but not ipsilateral sequence length. In contrast, the activity of reward-modulated DANs, largely distinct from those modulated by movement, was not lateralized. Finally, unilateral dopamine depletion impaired contralateral, but not ipsilateral, sequence length. These results indicate that movement-initiation DANs encode more than a general motivation signal and invigorate aspects of contralateral movements.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMendonça, Marcelo Dda Silva, Joaquim AlvesHernandez, Ledia FCastela, IvanObeso, JoséCosta, Rui M2024-03-06T23:52:27Z2024-02-122024-02-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/164567eng0960-9822PURE: 84056645https://doi.org/10.1016/j.cub.2024.01.067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:53:10Zoai:run.unl.pt:10362/164567Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:15.403596Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences |
title |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences |
spellingShingle |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences Mendonça, Marcelo D |
title_short |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences |
title_full |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences |
title_fullStr |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences |
title_full_unstemmed |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences |
title_sort |
Dopamine neuron activity encodes the length of upcoming contralateral movement sequences |
author |
Mendonça, Marcelo D |
author_facet |
Mendonça, Marcelo D da Silva, Joaquim Alves Hernandez, Ledia F Castela, Ivan Obeso, José Costa, Rui M |
author_role |
author |
author2 |
da Silva, Joaquim Alves Hernandez, Ledia F Castela, Ivan Obeso, José Costa, Rui M |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Mendonça, Marcelo D da Silva, Joaquim Alves Hernandez, Ledia F Castela, Ivan Obeso, José Costa, Rui M |
description |
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-03-06T23:52:27Z 2024-02-12 2024-02-12T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/164567 |
url |
http://hdl.handle.net/10362/164567 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0960-9822 PURE: 84056645 https://doi.org/10.1016/j.cub.2024.01.067 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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|
_version_ |
1799138178456616960 |