Dopamine neuron activity encodes the length of upcoming contralateral movement sequences

Detalhes bibliográficos
Autor(a) principal: Mendonça, Marcelo D.
Data de Publicação: 2024
Outros Autores: da Silva, Joaquim Alves, Hernandez, Ledia F., Castela, Ivan, Obeso, José, Costa, Rui M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/165023
Resumo: Funding Information: We thank Ana Vaz and Catarina Carvalho for mouse colony management, Thomas Akam and Hélio Rodrigues for help in behavioral box development and implementation, and the Champalimaud Hardware Platform (Filipe Carvalho, Artur Silva, and Dário Bento) for support in the development of the behavioral hardware setup. We thank Cristina Alcácer and Nuno Loureiro for their contributions during the 6-OHDA experiments. This work was supported by Fundação Para a Ciência e Tecnologia (FCT) through a doctoral fellowship ( SFRH/BD/119623/2016 to M.D.M.) and Fundação Luso-Americana para o Desenvolvimento (FLAD) by a visiting student fellowship ( 2018/31 to M.D.M.); by a doctoral fellowship from the Gulbenkian Foundation (to J.A.d.S.), a Marie Curie Fellowship ( MSCA-IF-RI 2016 to L.F.H.), and a Spanish Ministry of Innovation and Sciences doctoral fellowship ( BES-2016-077493 to I.C.); and by ERA-NET , ERC ( COG 617142 ), HHMI ( IEC 55007415 ), National Institutes of Health ( 5U19NS104649 ), and the Simons-Emory International Consortium on Motor Control and the Aligning Science Across Parkinson’s ( ASAP-020551 ) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF) to R.M.C. Further support was obtained from the research infrastructure Congento, co-funded by Lisboa2020 and FCT ( LISBOA-01-0145-FEDER-022170 ). Publisher Copyright: © 2024 The Authors
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spelling Dopamine neuron activity encodes the length of upcoming contralateral movement sequencesdopaminelateralitylengthmovementParkinson's diseasesubstantia nigra pars compactavigorBiochemistry, Genetics and Molecular Biology(all)Agricultural and Biological Sciences(all)Funding Information: We thank Ana Vaz and Catarina Carvalho for mouse colony management, Thomas Akam and Hélio Rodrigues for help in behavioral box development and implementation, and the Champalimaud Hardware Platform (Filipe Carvalho, Artur Silva, and Dário Bento) for support in the development of the behavioral hardware setup. We thank Cristina Alcácer and Nuno Loureiro for their contributions during the 6-OHDA experiments. This work was supported by Fundação Para a Ciência e Tecnologia (FCT) through a doctoral fellowship ( SFRH/BD/119623/2016 to M.D.M.) and Fundação Luso-Americana para o Desenvolvimento (FLAD) by a visiting student fellowship ( 2018/31 to M.D.M.); by a doctoral fellowship from the Gulbenkian Foundation (to J.A.d.S.), a Marie Curie Fellowship ( MSCA-IF-RI 2016 to L.F.H.), and a Spanish Ministry of Innovation and Sciences doctoral fellowship ( BES-2016-077493 to I.C.); and by ERA-NET , ERC ( COG 617142 ), HHMI ( IEC 55007415 ), National Institutes of Health ( 5U19NS104649 ), and the Simons-Emory International Consortium on Motor Control and the Aligning Science Across Parkinson’s ( ASAP-020551 ) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF) to R.M.C. Further support was obtained from the research infrastructure Congento, co-funded by Lisboa2020 and FCT ( LISBOA-01-0145-FEDER-022170 ). Publisher Copyright: © 2024 The AuthorsDopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement speed, and loss of these neurons leads to bradykinesia in Parkinson's disease (PD). However, other aspects of movement vigor are also affected in PD; for example, movement sequences are typically shorter. However, the relationship between the activity of DANs and the length of movement sequences is unknown. We imaged activity of SNc DANs in mice trained in a freely moving operant task, which relies on individual forelimb sequences. We uncovered a similar proportion of SNc DANs increasing their activity before either ipsilateral or contralateral sequences. However, the magnitude of this activity was higher for contralateral actions and was related to contralateral but not ipsilateral sequence length. In contrast, the activity of reward-modulated DANs, largely distinct from those modulated by movement, was not lateralized. Finally, unilateral dopamine depletion impaired contralateral, but not ipsilateral, sequence length. These results indicate that movement-initiation DANs encode more than a general motivation signal and invigorate aspects of contralateral movements.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMendonça, Marcelo D.da Silva, Joaquim AlvesHernandez, Ledia F.Castela, IvanObeso, JoséCosta, Rui M.2024-03-16T00:10:33Z2024-03-112024-03-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/165023eng0960-9822PURE: 85710708https://doi.org/10.1016/j.cub.2024.01.067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-18T01:49:06Zoai:run.unl.pt:10362/165023Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:02:07.761135Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
spellingShingle Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
Mendonça, Marcelo D.
dopamine
laterality
length
movement
Parkinson's disease
substantia nigra pars compacta
vigor
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
title_short Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_full Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_fullStr Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_full_unstemmed Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_sort Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
author Mendonça, Marcelo D.
author_facet Mendonça, Marcelo D.
da Silva, Joaquim Alves
Hernandez, Ledia F.
Castela, Ivan
Obeso, José
Costa, Rui M.
author_role author
author2 da Silva, Joaquim Alves
Hernandez, Ledia F.
Castela, Ivan
Obeso, José
Costa, Rui M.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Mendonça, Marcelo D.
da Silva, Joaquim Alves
Hernandez, Ledia F.
Castela, Ivan
Obeso, José
Costa, Rui M.
dc.subject.por.fl_str_mv dopamine
laterality
length
movement
Parkinson's disease
substantia nigra pars compacta
vigor
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
topic dopamine
laterality
length
movement
Parkinson's disease
substantia nigra pars compacta
vigor
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
description Funding Information: We thank Ana Vaz and Catarina Carvalho for mouse colony management, Thomas Akam and Hélio Rodrigues for help in behavioral box development and implementation, and the Champalimaud Hardware Platform (Filipe Carvalho, Artur Silva, and Dário Bento) for support in the development of the behavioral hardware setup. We thank Cristina Alcácer and Nuno Loureiro for their contributions during the 6-OHDA experiments. This work was supported by Fundação Para a Ciência e Tecnologia (FCT) through a doctoral fellowship ( SFRH/BD/119623/2016 to M.D.M.) and Fundação Luso-Americana para o Desenvolvimento (FLAD) by a visiting student fellowship ( 2018/31 to M.D.M.); by a doctoral fellowship from the Gulbenkian Foundation (to J.A.d.S.), a Marie Curie Fellowship ( MSCA-IF-RI 2016 to L.F.H.), and a Spanish Ministry of Innovation and Sciences doctoral fellowship ( BES-2016-077493 to I.C.); and by ERA-NET , ERC ( COG 617142 ), HHMI ( IEC 55007415 ), National Institutes of Health ( 5U19NS104649 ), and the Simons-Emory International Consortium on Motor Control and the Aligning Science Across Parkinson’s ( ASAP-020551 ) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF) to R.M.C. Further support was obtained from the research infrastructure Congento, co-funded by Lisboa2020 and FCT ( LISBOA-01-0145-FEDER-022170 ). Publisher Copyright: © 2024 The Authors
publishDate 2024
dc.date.none.fl_str_mv 2024-03-16T00:10:33Z
2024-03-11
2024-03-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/165023
url http://hdl.handle.net/10362/165023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0960-9822
PURE: 85710708
https://doi.org/10.1016/j.cub.2024.01.067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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