SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2813 |
Resumo: | COVID-19 is a highly selective disease in which SARS-CoV-2 infection can result in different clinical manifestations ranging from asymptomatic/mild to severe disease that requires hospitalization. In this study, we demonstrated that SARS-CoV-2 infection results in a glycosylation reprogramming of circulating lymphocytes at diagnosis. We identified a specific glycosignature of T cells, defined upon SARS-CoV-2 infection and apparently triggered by a serological factor. This specific glycan switch of T cells is detected at diagnosis being more pronounced in asymptomatic patients. We further demonstrated that asymptomatic patients display an increased expression of a viral-sensing receptor through the upregulation of DC-SIGN in monocytes. We showed that higher levels of DC-SIGN in monocytes at diagnosis correlates with better COVID-19 prognosis. This new evidence pave the way to the identification of a novel glycan-based response in T cells that may confer protection against SARS-CoV-2 infection in asymptomatic patients, highlighting a novel prognostic biomarker and potential therapeutic target. |
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SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at DiagnosisCOVID-19 is a highly selective disease in which SARS-CoV-2 infection can result in different clinical manifestations ranging from asymptomatic/mild to severe disease that requires hospitalization. In this study, we demonstrated that SARS-CoV-2 infection results in a glycosylation reprogramming of circulating lymphocytes at diagnosis. We identified a specific glycosignature of T cells, defined upon SARS-CoV-2 infection and apparently triggered by a serological factor. This specific glycan switch of T cells is detected at diagnosis being more pronounced in asymptomatic patients. We further demonstrated that asymptomatic patients display an increased expression of a viral-sensing receptor through the upregulation of DC-SIGN in monocytes. We showed that higher levels of DC-SIGN in monocytes at diagnosis correlates with better COVID-19 prognosis. This new evidence pave the way to the identification of a novel glycan-based response in T cells that may confer protection against SARS-CoV-2 infection in asymptomatic patients, highlighting a novel prognostic biomarker and potential therapeutic target.Williams & WilkinsRepositório Científico do Centro Hospitalar Universitário de Santo AntónioAlves, InêsVicente, Manuel MachadoGaifem, JoanaFernandes, ÂngelaDias, Ana MendesRodrigues, Cláudia SousaOliveira, José CarlosSeixas, NairMalheiro, LuisAbreu, MiguelSarmento e Castro, RuiPinho, Salomé Soares2023-10-17T11:47:51Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2813engAlves I, Vicente MM, Gaifem J, et al. SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis. J Immunol. 2021;207(6):1591-1598. doi:10.4049/jimmunol.21001310022-176710.4049/jimmunol.2100131info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:02:38Zoai:repositorio.chporto.pt:10400.16/2813Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:59.265059Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis |
title |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis |
spellingShingle |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis Alves, Inês |
title_short |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis |
title_full |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis |
title_fullStr |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis |
title_full_unstemmed |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis |
title_sort |
SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis |
author |
Alves, Inês |
author_facet |
Alves, Inês Vicente, Manuel Machado Gaifem, Joana Fernandes, Ângela Dias, Ana Mendes Rodrigues, Cláudia Sousa Oliveira, José Carlos Seixas, Nair Malheiro, Luis Abreu, Miguel Sarmento e Castro, Rui Pinho, Salomé Soares |
author_role |
author |
author2 |
Vicente, Manuel Machado Gaifem, Joana Fernandes, Ângela Dias, Ana Mendes Rodrigues, Cláudia Sousa Oliveira, José Carlos Seixas, Nair Malheiro, Luis Abreu, Miguel Sarmento e Castro, Rui Pinho, Salomé Soares |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Alves, Inês Vicente, Manuel Machado Gaifem, Joana Fernandes, Ângela Dias, Ana Mendes Rodrigues, Cláudia Sousa Oliveira, José Carlos Seixas, Nair Malheiro, Luis Abreu, Miguel Sarmento e Castro, Rui Pinho, Salomé Soares |
description |
COVID-19 is a highly selective disease in which SARS-CoV-2 infection can result in different clinical manifestations ranging from asymptomatic/mild to severe disease that requires hospitalization. In this study, we demonstrated that SARS-CoV-2 infection results in a glycosylation reprogramming of circulating lymphocytes at diagnosis. We identified a specific glycosignature of T cells, defined upon SARS-CoV-2 infection and apparently triggered by a serological factor. This specific glycan switch of T cells is detected at diagnosis being more pronounced in asymptomatic patients. We further demonstrated that asymptomatic patients display an increased expression of a viral-sensing receptor through the upregulation of DC-SIGN in monocytes. We showed that higher levels of DC-SIGN in monocytes at diagnosis correlates with better COVID-19 prognosis. This new evidence pave the way to the identification of a novel glycan-based response in T cells that may confer protection against SARS-CoV-2 infection in asymptomatic patients, highlighting a novel prognostic biomarker and potential therapeutic target. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-10-17T11:47:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2813 |
url |
http://hdl.handle.net/10400.16/2813 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Alves I, Vicente MM, Gaifem J, et al. SARS-CoV-2 Infection Drives a Glycan Switch of Peripheral T Cells at Diagnosis. J Immunol. 2021;207(6):1591-1598. doi:10.4049/jimmunol.2100131 0022-1767 10.4049/jimmunol.2100131 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Williams & Wilkins |
publisher.none.fl_str_mv |
Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133650248269824 |