New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis

Detalhes bibliográficos
Autor(a) principal: Eiriz, Maria F.
Data de Publicação: 2014
Outros Autores: Valero, Jorge, Malva, João O., Bernardino, Liliana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/109436
https://doi.org/10.3389/fnins.2014.00142
Resumo: The subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact in brain repair. Histamine, a neurotransmitter and immune mediator, has been recently described to modulate proliferation and commitment of NSCs. Histamine levels are increased in the brain parenchyma and at the cerebrospinal fluid (CSF) upon inflammation and brain injury, thus being able to modulate neurogenesis. Herein, we add new data showing that in vivo administration of histamine in the lateral ventricles has a potent proneurogenic effect, increasing the production of new neuroblasts in the SVZ that ultimately reach the olfactory bulb (OB). This report emphasizes the multidimensional effects of histamine in the modulation of NSCs dynamics and sheds light into the promising therapeutic role of histamine for brain regenerative medicine.
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spelling New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesissubventricular zoneolfactory bulbneural stem cellshistamineneurogenesisThe subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact in brain repair. Histamine, a neurotransmitter and immune mediator, has been recently described to modulate proliferation and commitment of NSCs. Histamine levels are increased in the brain parenchyma and at the cerebrospinal fluid (CSF) upon inflammation and brain injury, thus being able to modulate neurogenesis. Herein, we add new data showing that in vivo administration of histamine in the lateral ventricles has a potent proneurogenic effect, increasing the production of new neuroblasts in the SVZ that ultimately reach the olfactory bulb (OB). This report emphasizes the multidimensional effects of histamine in the modulation of NSCs dynamics and sheds light into the promising therapeutic role of histamine for brain regenerative medicine.Frontiers Media S.A.2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109436http://hdl.handle.net/10316/109436https://doi.org/10.3389/fnins.2014.00142eng1662-4548Eiriz, Maria F.Valero, JorgeMalva, João O.Bernardino, Lilianainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-16T08:00:44Zoai:estudogeral.uc.pt:10316/109436Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:38.159257Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
title New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
spellingShingle New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
Eiriz, Maria F.
subventricular zone
olfactory bulb
neural stem cells
histamine
neurogenesis
title_short New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
title_full New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
title_fullStr New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
title_full_unstemmed New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
title_sort New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis
author Eiriz, Maria F.
author_facet Eiriz, Maria F.
Valero, Jorge
Malva, João O.
Bernardino, Liliana
author_role author
author2 Valero, Jorge
Malva, João O.
Bernardino, Liliana
author2_role author
author
author
dc.contributor.author.fl_str_mv Eiriz, Maria F.
Valero, Jorge
Malva, João O.
Bernardino, Liliana
dc.subject.por.fl_str_mv subventricular zone
olfactory bulb
neural stem cells
histamine
neurogenesis
topic subventricular zone
olfactory bulb
neural stem cells
histamine
neurogenesis
description The subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact in brain repair. Histamine, a neurotransmitter and immune mediator, has been recently described to modulate proliferation and commitment of NSCs. Histamine levels are increased in the brain parenchyma and at the cerebrospinal fluid (CSF) upon inflammation and brain injury, thus being able to modulate neurogenesis. Herein, we add new data showing that in vivo administration of histamine in the lateral ventricles has a potent proneurogenic effect, increasing the production of new neuroblasts in the SVZ that ultimately reach the olfactory bulb (OB). This report emphasizes the multidimensional effects of histamine in the modulation of NSCs dynamics and sheds light into the promising therapeutic role of histamine for brain regenerative medicine.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109436
http://hdl.handle.net/10316/109436
https://doi.org/10.3389/fnins.2014.00142
url http://hdl.handle.net/10316/109436
https://doi.org/10.3389/fnins.2014.00142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-4548
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dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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