Histamine stimulates neurogenesis in the rodent subventricular zone

Detalhes bibliográficos
Autor(a) principal: Bernardino, Liliana
Data de Publicação: 2012
Outros Autores: Eiriz, Maria Francisca, Santos, Tiago, Xapelli, Sara, Grade, Sofia, Rosa, Alexandra Isabel, Cortes, Luisa, Ferreira, Raquel, Bragança, José, Agasse, Fabienne, Ferreira, Lino, Malva, Joao O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/11105
Resumo: Neural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/progenitor cells. This proneurogenic effect depends on histamine 1 receptor activation and involves epigenetic modifications and increased expression of Mash1, Dlx2, and Ngn1 genes. Biocompatible poly (lactic-co-glycolic acid) microparticles, engineered to release histamine in a controlled and prolonged manner, also triggered robust neuronal differentiation in vitro. Preconditioning with histamine-loaded microparticles facilitated neuronal differentiation of SVZ-GFP cells grafted in hippocampal slices and in in vivo rodent brain. We propose that neuronal commitment triggered by histamine per se or released from biomaterial-derived vehicles may represent a new tool for brain repair strategies. STEM CELLS 2012; 30:773784
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spelling Histamine stimulates neurogenesis in the rodent subventricular zoneEmbryonic Stem-CellsNecrosis-Factor-AlphaNeuronal differentiationCsf histaminePrecolumn derivatizationPromotes neurogenesisTele-MethylhistamineCerebrospinal-fluidProgenitor cellsBrainNeural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/progenitor cells. This proneurogenic effect depends on histamine 1 receptor activation and involves epigenetic modifications and increased expression of Mash1, Dlx2, and Ngn1 genes. Biocompatible poly (lactic-co-glycolic acid) microparticles, engineered to release histamine in a controlled and prolonged manner, also triggered robust neuronal differentiation in vitro. Preconditioning with histamine-loaded microparticles facilitated neuronal differentiation of SVZ-GFP cells grafted in hippocampal slices and in in vivo rodent brain. We propose that neuronal commitment triggered by histamine per se or released from biomaterial-derived vehicles may represent a new tool for brain repair strategies. STEM CELLS 2012; 30:773784Fundacao para a Ciencia e a Tecnologia-Portugal [SFRH/BD/42848/2008, SFRH/BPD/34841/2007, PTDC/SAU-NEU/104415/2008, PTDC/SAU-NEU/101783/2008, PTDC/CTM/099659/2008]; Fundacao Calouste Gulbenkian [96542]Wiley-BlackwellSapientiaBernardino, LilianaEiriz, Maria FranciscaSantos, TiagoXapelli, SaraGrade, SofiaRosa, Alexandra IsabelCortes, LuisaFerreira, RaquelBragança, JoséAgasse, FabienneFerreira, LinoMalva, Joao O.2018-12-07T14:52:31Z2012-042012-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11105eng1066-509910.1002/stem.1042info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:22:51Zoai:sapientia.ualg.pt:10400.1/11105Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:37.924184Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Histamine stimulates neurogenesis in the rodent subventricular zone
title Histamine stimulates neurogenesis in the rodent subventricular zone
spellingShingle Histamine stimulates neurogenesis in the rodent subventricular zone
Bernardino, Liliana
Embryonic Stem-Cells
Necrosis-Factor-Alpha
Neuronal differentiation
Csf histamine
Precolumn derivatization
Promotes neurogenesis
Tele-Methylhistamine
Cerebrospinal-fluid
Progenitor cells
Brain
title_short Histamine stimulates neurogenesis in the rodent subventricular zone
title_full Histamine stimulates neurogenesis in the rodent subventricular zone
title_fullStr Histamine stimulates neurogenesis in the rodent subventricular zone
title_full_unstemmed Histamine stimulates neurogenesis in the rodent subventricular zone
title_sort Histamine stimulates neurogenesis in the rodent subventricular zone
author Bernardino, Liliana
author_facet Bernardino, Liliana
Eiriz, Maria Francisca
Santos, Tiago
Xapelli, Sara
Grade, Sofia
Rosa, Alexandra Isabel
Cortes, Luisa
Ferreira, Raquel
Bragança, José
Agasse, Fabienne
Ferreira, Lino
Malva, Joao O.
author_role author
author2 Eiriz, Maria Francisca
Santos, Tiago
Xapelli, Sara
Grade, Sofia
Rosa, Alexandra Isabel
Cortes, Luisa
Ferreira, Raquel
Bragança, José
Agasse, Fabienne
Ferreira, Lino
Malva, Joao O.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Bernardino, Liliana
Eiriz, Maria Francisca
Santos, Tiago
Xapelli, Sara
Grade, Sofia
Rosa, Alexandra Isabel
Cortes, Luisa
Ferreira, Raquel
Bragança, José
Agasse, Fabienne
Ferreira, Lino
Malva, Joao O.
dc.subject.por.fl_str_mv Embryonic Stem-Cells
Necrosis-Factor-Alpha
Neuronal differentiation
Csf histamine
Precolumn derivatization
Promotes neurogenesis
Tele-Methylhistamine
Cerebrospinal-fluid
Progenitor cells
Brain
topic Embryonic Stem-Cells
Necrosis-Factor-Alpha
Neuronal differentiation
Csf histamine
Precolumn derivatization
Promotes neurogenesis
Tele-Methylhistamine
Cerebrospinal-fluid
Progenitor cells
Brain
description Neural stem/progenitor cells present in the subventricular zone (SVZ) are a potential source of repairing cells after injury. Therefore, the identification of novel players that modulate neural stem cells differentiation can have a huge impact in stem cell-based therapies. Herein, we describe a unique role of histamine in inducing functional neuronal differentiation from cultured mouse SVZ stem/progenitor cells. This proneurogenic effect depends on histamine 1 receptor activation and involves epigenetic modifications and increased expression of Mash1, Dlx2, and Ngn1 genes. Biocompatible poly (lactic-co-glycolic acid) microparticles, engineered to release histamine in a controlled and prolonged manner, also triggered robust neuronal differentiation in vitro. Preconditioning with histamine-loaded microparticles facilitated neuronal differentiation of SVZ-GFP cells grafted in hippocampal slices and in in vivo rodent brain. We propose that neuronal commitment triggered by histamine per se or released from biomaterial-derived vehicles may represent a new tool for brain repair strategies. STEM CELLS 2012; 30:773784
publishDate 2012
dc.date.none.fl_str_mv 2012-04
2012-04-01T00:00:00Z
2018-12-07T14:52:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/11105
url http://hdl.handle.net/10400.1/11105
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1066-5099
10.1002/stem.1042
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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