The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.25759/spmfr.477 |
Resumo: | Introduction: Dupuytren’s disease (DD) is a benign and progressive fibroproliferative disease that involves the palmar fascia, where collagenous cords form from the overlay of nodular fibrotic tissue. Clostridium histolyticum collagenase (CHC) is a minimally invasive option for the treatment of advanced DD. CHC allows collagen lysis, leading to the rupture of fibrous cords. This review aims to reflect on the existing scientific evidence about the role of CHC in the treatment of DD.Methods: The study presented is a systematic review. Authors followed PRISMA reporting guidelines. The search was performed using the following databases: PubMed, ClinicalTrials.gov and Cochrane Central Registry of Controlled Trials (CENTRAL). As inclusion criteria, randomized and non-randomized clinical trials and observational studies were considered. As an exclusion criterion, all studies not written in English were excluded. The primary outcome was efficacy, through reduced contracture or increased range of motion. Safety/adverse effects, degree of contracture recurrence and patient satisfaction with the application of this technique were considered secondary outcomes. All relevant articles were systematically reviewed by 2 reviewers.Results: The search resulted in 30 studies, 15 of which were selected by 2 independent reviewers. CHC therapy was shown to be superior in efficacy when compared to placebo and similar results when compared to surgical options. Regarding secondary outcomes, CHC therapy proved to be a safe treatment with a high patient satisfaction, with low recurrence rates and similar recurrence rates after surgical treatments with 5 years of follow-up.Conclusion: CHC has proven to be an effective and safe therapy in DD patients, as well as a non-invasive alternative to surgery. |
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The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic ReviewO Papel da Colagenase Clostridium histolyticum na Doença de Dupuytren: Uma Revisão SistemáticaClostridium histolyticum; Dupuytren Contracture; Microbial CollagenaseClostridium histolyticum; Colagenase Microbiana; Contratura de DupuytrenIntroduction: Dupuytren’s disease (DD) is a benign and progressive fibroproliferative disease that involves the palmar fascia, where collagenous cords form from the overlay of nodular fibrotic tissue. Clostridium histolyticum collagenase (CHC) is a minimally invasive option for the treatment of advanced DD. CHC allows collagen lysis, leading to the rupture of fibrous cords. This review aims to reflect on the existing scientific evidence about the role of CHC in the treatment of DD.Methods: The study presented is a systematic review. Authors followed PRISMA reporting guidelines. The search was performed using the following databases: PubMed, ClinicalTrials.gov and Cochrane Central Registry of Controlled Trials (CENTRAL). As inclusion criteria, randomized and non-randomized clinical trials and observational studies were considered. As an exclusion criterion, all studies not written in English were excluded. The primary outcome was efficacy, through reduced contracture or increased range of motion. Safety/adverse effects, degree of contracture recurrence and patient satisfaction with the application of this technique were considered secondary outcomes. All relevant articles were systematically reviewed by 2 reviewers.Results: The search resulted in 30 studies, 15 of which were selected by 2 independent reviewers. CHC therapy was shown to be superior in efficacy when compared to placebo and similar results when compared to surgical options. Regarding secondary outcomes, CHC therapy proved to be a safe treatment with a high patient satisfaction, with low recurrence rates and similar recurrence rates after surgical treatments with 5 years of follow-up.Conclusion: CHC has proven to be an effective and safe therapy in DD patients, as well as a non-invasive alternative to surgery.Introdução: A doença de Dupuytren (DD) é uma doença fibroproliferativa benigna e progressiva que envolve a fáscia palmar, onde são formados cordões de colagénio a partir da sobreposição de tecido fibrótico nodular. A infiltração da colagenase Clostridium histolyticum (CCH) é uma opção minimamente invasiva para o tratamento da DD avançada. A CCH permite a lise do colagénio, despoletando a rotura dos cordões fibrosos. Esta revisão visa refletir sobre a evidência científica existente acerca do papel da CCH no tratamento da DD.Métodos: O estudo apresentado é uma revisão sistemática. Os autores seguiram as guidelines PRISMA. A pesquisa foi realizada nas seguintes bases de dados: PubMed, ClinicalTrials.gov e Cochrane Central Registry of Controlled Trials (CENTRAL). Como critérios de inclusão, foram considerados ensaios clínicos randomizados e não randomizados e estudos observacionais. Como critério de exclusão, todos os estudos não escritos em inglês foram excluídos. O outcome primário foi a eficácia, traduzida por redução da contratura em flexão ou aumento da amplitude de movimento. Segurança/efeitos adversos, grau de recorrência da contratura e satisfação do doente com a aplicação desta técnica foram considerados outcomes secundários. Todos os artigos relevantes foram sistematicamente revistos por 2 elementos.Resultados: Da pesquisa resultaram 30 estudos, 15 dos quais foram selecionados por 2 revisores independentes. A terapia com CCH mostrou ser superior em eficácia quando comparada ao placebo e apresentou resultados semelhantes quando comparada às opções cirúrgicas. Em relação aos outcomes secundários, a terapia com CCH provou ser um tratamento seguro com elevado grau de satisfação do doente, com baixas taxas de recorrência e taxas de recorrência semelhantes após tratamentos cirúrgicos com 5 anos de follow-up.Conclusão: A CCH provou ser uma terapia eficaz e segura em pacientes com DD, bem como uma alternativa não invasiva à cirurgia.Sociedade Portuguesa de Medicina Física e de Reabilitação2023-11-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.25759/spmfr.477https://doi.org/10.25759/spmfr.477Revista da Sociedade Portuguesa de Medicina Física e de Reabilitação; v. 35, n. 3 (2023): Ano 31; 97-1050872-9204reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://spmfrjournal.org/index.php/spmfr/article/view/477https://spmfrjournal.org/index.php/spmfr/article/view/477/271Copyright (c) 2023 Revista da Sociedade Portuguesa de Medicina Física e de Reabilitaçãohttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessMoreira Sousa, RuiRego Diniz, João; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, PortugalFerreira Pires, Gonçalo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, PortugalCouto Soares, Diogo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal2024-01-26T06:20:58Zoai:ojs.pkp.sfu.ca:article/477Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:57:37.092594Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review O Papel da Colagenase Clostridium histolyticum na Doença de Dupuytren: Uma Revisão Sistemática |
title |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review |
spellingShingle |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review Moreira Sousa, Rui Clostridium histolyticum; Dupuytren Contracture; Microbial Collagenase Clostridium histolyticum; Colagenase Microbiana; Contratura de Dupuytren |
title_short |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review |
title_full |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review |
title_fullStr |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review |
title_full_unstemmed |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review |
title_sort |
The Role of Collagenase Clostridium histolyticum in Dupuytren’s Disease: A Systematic Review |
author |
Moreira Sousa, Rui |
author_facet |
Moreira Sousa, Rui Rego Diniz, João; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal Ferreira Pires, Gonçalo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal Couto Soares, Diogo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal |
author_role |
author |
author2 |
Rego Diniz, João; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal Ferreira Pires, Gonçalo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal Couto Soares, Diogo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Moreira Sousa, Rui Rego Diniz, João; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal Ferreira Pires, Gonçalo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal Couto Soares, Diogo; Serviço de Medicina Física e de Reabilitação, Centro Hospitalar do Tâmega e Sousa, Guilhufe, Portugal |
dc.subject.por.fl_str_mv |
Clostridium histolyticum; Dupuytren Contracture; Microbial Collagenase Clostridium histolyticum; Colagenase Microbiana; Contratura de Dupuytren |
topic |
Clostridium histolyticum; Dupuytren Contracture; Microbial Collagenase Clostridium histolyticum; Colagenase Microbiana; Contratura de Dupuytren |
description |
Introduction: Dupuytren’s disease (DD) is a benign and progressive fibroproliferative disease that involves the palmar fascia, where collagenous cords form from the overlay of nodular fibrotic tissue. Clostridium histolyticum collagenase (CHC) is a minimally invasive option for the treatment of advanced DD. CHC allows collagen lysis, leading to the rupture of fibrous cords. This review aims to reflect on the existing scientific evidence about the role of CHC in the treatment of DD.Methods: The study presented is a systematic review. Authors followed PRISMA reporting guidelines. The search was performed using the following databases: PubMed, ClinicalTrials.gov and Cochrane Central Registry of Controlled Trials (CENTRAL). As inclusion criteria, randomized and non-randomized clinical trials and observational studies were considered. As an exclusion criterion, all studies not written in English were excluded. The primary outcome was efficacy, through reduced contracture or increased range of motion. Safety/adverse effects, degree of contracture recurrence and patient satisfaction with the application of this technique were considered secondary outcomes. All relevant articles were systematically reviewed by 2 reviewers.Results: The search resulted in 30 studies, 15 of which were selected by 2 independent reviewers. CHC therapy was shown to be superior in efficacy when compared to placebo and similar results when compared to surgical options. Regarding secondary outcomes, CHC therapy proved to be a safe treatment with a high patient satisfaction, with low recurrence rates and similar recurrence rates after surgical treatments with 5 years of follow-up.Conclusion: CHC has proven to be an effective and safe therapy in DD patients, as well as a non-invasive alternative to surgery. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.25759/spmfr.477 https://doi.org/10.25759/spmfr.477 |
url |
https://doi.org/10.25759/spmfr.477 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://spmfrjournal.org/index.php/spmfr/article/view/477 https://spmfrjournal.org/index.php/spmfr/article/view/477/271 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Revista da Sociedade Portuguesa de Medicina Física e de Reabilitação http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Revista da Sociedade Portuguesa de Medicina Física e de Reabilitação http://creativecommons.org/licenses/by-nc-nd/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Física e de Reabilitação |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Medicina Física e de Reabilitação |
dc.source.none.fl_str_mv |
Revista da Sociedade Portuguesa de Medicina Física e de Reabilitação; v. 35, n. 3 (2023): Ano 31; 97-105 0872-9204 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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