Aging Hallmarks: The Benefits of Physical Exercise

Detalhes bibliográficos
Autor(a) principal: Rebelo-Marques, Alexandre
Data de Publicação: 2018
Outros Autores: Lages, Adriana De Sousa, Andrade, Renato, Ribeiro, Carlos Fontes, Mota-Pinto, Anabela, Carrilho, Francisco, Espregueira-Mendes, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/80903
https://doi.org/10.3389/fendo.2018.00258
Resumo: World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.
id RCAP_80aa6ee6deb5755d8322db6419d3f0eb
oai_identifier_str oai:estudogeral.uc.pt:10316/80903
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Aging Hallmarks: The Benefits of Physical ExerciseAging/EnvelhecimentoExercício Físico/Physical ExerciseWorld population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.Frontiers2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/80903http://hdl.handle.net/10316/80903https://doi.org/10.3389/fendo.2018.00258eng29887832https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/fullRebelo-Marques, AlexandreLages, Adriana De SousaAndrade, RenatoRibeiro, Carlos FontesMota-Pinto, AnabelaCarrilho, FranciscoEspregueira-Mendes, Joãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-08-28T13:21:55Zoai:estudogeral.uc.pt:10316/80903Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:03:09.237667Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Aging Hallmarks: The Benefits of Physical Exercise
title Aging Hallmarks: The Benefits of Physical Exercise
spellingShingle Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, Alexandre
Aging/Envelhecimento
Exercício Físico/Physical Exercise
title_short Aging Hallmarks: The Benefits of Physical Exercise
title_full Aging Hallmarks: The Benefits of Physical Exercise
title_fullStr Aging Hallmarks: The Benefits of Physical Exercise
title_full_unstemmed Aging Hallmarks: The Benefits of Physical Exercise
title_sort Aging Hallmarks: The Benefits of Physical Exercise
author Rebelo-Marques, Alexandre
author_facet Rebelo-Marques, Alexandre
Lages, Adriana De Sousa
Andrade, Renato
Ribeiro, Carlos Fontes
Mota-Pinto, Anabela
Carrilho, Francisco
Espregueira-Mendes, João
author_role author
author2 Lages, Adriana De Sousa
Andrade, Renato
Ribeiro, Carlos Fontes
Mota-Pinto, Anabela
Carrilho, Francisco
Espregueira-Mendes, João
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rebelo-Marques, Alexandre
Lages, Adriana De Sousa
Andrade, Renato
Ribeiro, Carlos Fontes
Mota-Pinto, Anabela
Carrilho, Francisco
Espregueira-Mendes, João
dc.subject.por.fl_str_mv Aging/Envelhecimento
Exercício Físico/Physical Exercise
topic Aging/Envelhecimento
Exercício Físico/Physical Exercise
description World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/80903
http://hdl.handle.net/10316/80903
https://doi.org/10.3389/fendo.2018.00258
url http://hdl.handle.net/10316/80903
https://doi.org/10.3389/fendo.2018.00258
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 29887832
https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/full
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133924525342720

Registros relacionados