Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

Detalhes bibliográficos
Autor(a) principal: Silva, João Carlos
Data de Publicação: 2020
Outros Autores: Ponte, Ana, Mota, Margarida, Pinho, Rolando, Vieira, Nuno, Oliveira, Rosa, Mota-Carvalho, Nelson, Gomes, Ana Catarina, Afecto, Edgar, Carvalho, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/31815
Resumo: Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
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spelling Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceaeFecal microbiota transplantationCarbapenamase-producing enterobacteriaceaeMultidrug-resistant infectionsDecolonizationIntestinal carriageBackground and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.Sociedad Española de Patología DigestivaVeritati - Repositório Institucional da Universidade Católica PortuguesaSilva, João CarlosPonte, AnaMota, MargaridaPinho, RolandoVieira, NunoOliveira, RosaMota-Carvalho, NelsonGomes, Ana CatarinaAfecto, EdgarCarvalho, João2021-01-29T11:46:45Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/31815engSilva, J. C., Ponte, A., Mota, M., Pinho, R., Vieira, N., Oliveira, R., ... Edgar, A. (2020). Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae. Revista Espanola de Enfermedades Digestivas, 112(12), 925-9281130-010810.17235/reed.2020.7150/20202340-41678509632878533118360WOS:000597214000006info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:37:21Zoai:repositorio.ucp.pt:10400.14/31815Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:25:40.724003Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
title Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
spellingShingle Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
Silva, João Carlos
Fecal microbiota transplantation
Carbapenamase-producing enterobacteriaceae
Multidrug-resistant infections
Decolonization
Intestinal carriage
title_short Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
title_full Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
title_fullStr Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
title_full_unstemmed Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
title_sort Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae
author Silva, João Carlos
author_facet Silva, João Carlos
Ponte, Ana
Mota, Margarida
Pinho, Rolando
Vieira, Nuno
Oliveira, Rosa
Mota-Carvalho, Nelson
Gomes, Ana Catarina
Afecto, Edgar
Carvalho, João
author_role author
author2 Ponte, Ana
Mota, Margarida
Pinho, Rolando
Vieira, Nuno
Oliveira, Rosa
Mota-Carvalho, Nelson
Gomes, Ana Catarina
Afecto, Edgar
Carvalho, João
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Silva, João Carlos
Ponte, Ana
Mota, Margarida
Pinho, Rolando
Vieira, Nuno
Oliveira, Rosa
Mota-Carvalho, Nelson
Gomes, Ana Catarina
Afecto, Edgar
Carvalho, João
dc.subject.por.fl_str_mv Fecal microbiota transplantation
Carbapenamase-producing enterobacteriaceae
Multidrug-resistant infections
Decolonization
Intestinal carriage
topic Fecal microbiota transplantation
Carbapenamase-producing enterobacteriaceae
Multidrug-resistant infections
Decolonization
Intestinal carriage
description Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-01-29T11:46:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/31815
url http://hdl.handle.net/10400.14/31815
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva, J. C., Ponte, A., Mota, M., Pinho, R., Vieira, N., Oliveira, R., ... Edgar, A. (2020). Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae. Revista Espanola de Enfermedades Digestivas, 112(12), 925-928
1130-0108
10.17235/reed.2020.7150/2020
2340-4167
85096328785
33118360
WOS:000597214000006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Española de Patología Digestiva
publisher.none.fl_str_mv Sociedad Española de Patología Digestiva
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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