Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines

Detalhes bibliográficos
Autor(a) principal: Mendes, Paulo J.
Data de Publicação: 2012
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/7208
Resumo: A new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.
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spelling Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell linesOrganometallic ComplexesAnticancerA new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.PubMed2013-01-11T14:38:30Z2013-01-112012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/7208http://hdl.handle.net/10174/7208engTânia S. Morais, Tiago J. L. Silva, Fernanda Marques, Isabel Santos, M. Paula Robalo, Fernando Avecilla, Paulo J. Amorim Madeira, Paulo J.G. Mendes, M. Helena Garcia; “Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines” Journal of Inorganic Biochemistry, 2012, 114, 65-74 doi: 10.1016/j.jinorgbio.2012.04.014http://www.ncbi.nlm.nih.gov/pubmed/22698866QUIpjgm@uevora.pt306Mendes, Paulo J.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:47:17Zoai:dspace.uevora.pt:10174/7208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:01:48.910775Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
title Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
spellingShingle Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
Mendes, Paulo J.
Organometallic Complexes
Anticancer
title_short Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
title_full Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
title_fullStr Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
title_full_unstemmed Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
title_sort Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
author Mendes, Paulo J.
author_facet Mendes, Paulo J.
author_role author
dc.contributor.author.fl_str_mv Mendes, Paulo J.
dc.subject.por.fl_str_mv Organometallic Complexes
Anticancer
topic Organometallic Complexes
Anticancer
description A new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01T00:00:00Z
2013-01-11T14:38:30Z
2013-01-11
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/7208
http://hdl.handle.net/10174/7208
url http://hdl.handle.net/10174/7208
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tânia S. Morais, Tiago J. L. Silva, Fernanda Marques, Isabel Santos, M. Paula Robalo, Fernando Avecilla, Paulo J. Amorim Madeira, Paulo J.G. Mendes, M. Helena Garcia; “Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines” Journal of Inorganic Biochemistry, 2012, 114, 65-74 doi: 10.1016/j.jinorgbio.2012.04.014
http://www.ncbi.nlm.nih.gov/pubmed/22698866
QUI
pjgm@uevora.pt
306
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