Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/7208 |
Resumo: | A new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data. |
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Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell linesOrganometallic ComplexesAnticancerA new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.PubMed2013-01-11T14:38:30Z2013-01-112012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/7208http://hdl.handle.net/10174/7208engTânia S. Morais, Tiago J. L. Silva, Fernanda Marques, Isabel Santos, M. Paula Robalo, Fernando Avecilla, Paulo J. Amorim Madeira, Paulo J.G. Mendes, M. Helena Garcia; “Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines” Journal of Inorganic Biochemistry, 2012, 114, 65-74 doi: 10.1016/j.jinorgbio.2012.04.014http://www.ncbi.nlm.nih.gov/pubmed/22698866QUIpjgm@uevora.pt306Mendes, Paulo J.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:47:17Zoai:dspace.uevora.pt:10174/7208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:01:48.910775Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
title |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
spellingShingle |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines Mendes, Paulo J. Organometallic Complexes Anticancer |
title_short |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
title_full |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
title_fullStr |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
title_full_unstemmed |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
title_sort |
Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines |
author |
Mendes, Paulo J. |
author_facet |
Mendes, Paulo J. |
author_role |
author |
dc.contributor.author.fl_str_mv |
Mendes, Paulo J. |
dc.subject.por.fl_str_mv |
Organometallic Complexes Anticancer |
topic |
Organometallic Complexes Anticancer |
description |
A new family of "RuCp" (Cp=η(5)-C(5)H(5)) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PC3. IC(50) values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01T00:00:00Z 2013-01-11T14:38:30Z 2013-01-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/7208 http://hdl.handle.net/10174/7208 |
url |
http://hdl.handle.net/10174/7208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tânia S. Morais, Tiago J. L. Silva, Fernanda Marques, Isabel Santos, M. Paula Robalo, Fernando Avecilla, Paulo J. Amorim Madeira, Paulo J.G. Mendes, M. Helena Garcia; “Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines” Journal of Inorganic Biochemistry, 2012, 114, 65-74 doi: 10.1016/j.jinorgbio.2012.04.014 http://www.ncbi.nlm.nih.gov/pubmed/22698866 QUI pjgm@uevora.pt 306 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
PubMed |
publisher.none.fl_str_mv |
PubMed |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799136501692366848 |