Blastic Plasmacytoid Dendritic Cell Neoplasm

Detalhes bibliográficos
Autor(a) principal: Lencastre, A
Data de Publicação: 2013
Outros Autores: Farinha, P, Cabete, J, Ferreira, G, João, A, Lestre, S
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/1607
Resumo: Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise.
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spelling Blastic Plasmacytoid Dendritic Cell NeoplasmNeoplasia Blástica de Células Dendríticas PlasmocitóidesBiópsiaCélulas DendríticasMedula ÓsseaLeucemia/PatologiaHSAC DERResultado FatalCitometria de FluxoInvasão NeoplásicaPeleNeoplasias da PeleBlastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise.ScieloRepositório do Centro Hospitalar Universitário de Lisboa Central, EPELencastre, AFarinha, PCabete, JFerreira, GJoão, ALestre, S2013-12-20T17:46:51Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/1607engAn Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):158-61info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:32:25Zoai:repositorio.chlc.min-saude.pt:10400.17/1607Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:03.970534Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Blastic Plasmacytoid Dendritic Cell Neoplasm
Neoplasia Blástica de Células Dendríticas Plasmocitóides
title Blastic Plasmacytoid Dendritic Cell Neoplasm
spellingShingle Blastic Plasmacytoid Dendritic Cell Neoplasm
Lencastre, A
Biópsia
Células Dendríticas
Medula Óssea
Leucemia/Patologia
HSAC DER
Resultado Fatal
Citometria de Fluxo
Invasão Neoplásica
Pele
Neoplasias da Pele
title_short Blastic Plasmacytoid Dendritic Cell Neoplasm
title_full Blastic Plasmacytoid Dendritic Cell Neoplasm
title_fullStr Blastic Plasmacytoid Dendritic Cell Neoplasm
title_full_unstemmed Blastic Plasmacytoid Dendritic Cell Neoplasm
title_sort Blastic Plasmacytoid Dendritic Cell Neoplasm
author Lencastre, A
author_facet Lencastre, A
Farinha, P
Cabete, J
Ferreira, G
João, A
Lestre, S
author_role author
author2 Farinha, P
Cabete, J
Ferreira, G
João, A
Lestre, S
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Lencastre, A
Farinha, P
Cabete, J
Ferreira, G
João, A
Lestre, S
dc.subject.por.fl_str_mv Biópsia
Células Dendríticas
Medula Óssea
Leucemia/Patologia
HSAC DER
Resultado Fatal
Citometria de Fluxo
Invasão Neoplásica
Pele
Neoplasias da Pele
topic Biópsia
Células Dendríticas
Medula Óssea
Leucemia/Patologia
HSAC DER
Resultado Fatal
Citometria de Fluxo
Invasão Neoplásica
Pele
Neoplasias da Pele
description Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-20T17:46:51Z
2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/1607
url http://hdl.handle.net/10400.17/1607
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):158-61
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Scielo
publisher.none.fl_str_mv Scielo
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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