Gut microbiota profile of COVID-19 patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/146185 |
Resumo: | Funding Information: The authors acknowledge financial support from Instituto Politécnico de Lisboa that supported this project with the grant Microcovid. This project was also partially supported by FCT/MCTES (UIDB/05608/2020 and UIDP/05608/2020). Publisher Copyright: Copyright © 2022 Nobre, Delgadinho, Silva, Mendes, Mateus, Ribeiro, Costa, Lopes, Pedroso, Trigueiros, Rodrigues, de Sousa and Brito. |
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Gut microbiota profile of COVID-19 patientsPrognosis and risk stratification (MicroCOVID-19 study)COVID-19dysbiosismicrobiomemicrobiotanext generation sequencingprognosisrisk stratificationMicrobiologyMicrobiology (medical)SDG 3 - Good Health and Well-beingFunding Information: The authors acknowledge financial support from Instituto Politécnico de Lisboa that supported this project with the grant Microcovid. This project was also partially supported by FCT/MCTES (UIDB/05608/2020 and UIDP/05608/2020). Publisher Copyright: Copyright © 2022 Nobre, Delgadinho, Silva, Mendes, Mateus, Ribeiro, Costa, Lopes, Pedroso, Trigueiros, Rodrigues, de Sousa and Brito.Background: Gut microbiota is intrinsically associated with the immune system and can promote or suppress infectious diseases, especially viral infections. This study aims to characterize and compare the microbiota profile of infected patients with SARS-CoV-2 (milder or severe symptoms), non-infected people, and recovered patients. This is a national, transversal, observational, multicenter, and case–control study that analyzed the microbiota of COVID-19 patients with mild or severe symptoms at home, at the hospital, or in the intensive care unit, patients already recovered, and healthy volunteers cohabiting with COVID-19 patients. DNA was isolated from stool samples and sequenced in a NGS platform. A demographic questionnaire was also applied. Statistical analysis was performed in SPSS. Results: Firmicutes/Bacteroidetes ratios were found to be significantly lower in infected patients (1.61 and 2.57) compared to healthy volunteers (3.23) and recovered patients (3.89). Furthermore, the microbiota composition differed significantly between healthy volunteers, mild and severe COVID-19 patients, and recovered patients. Furthermore, Escherichia coli, Actinomyces naeslundii, and Dorea longicatena were shown to be more frequent in severe cases. The most common COVID-19 symptoms were linked to certain microbiome groups. Conclusion: We can conclude that microbiota composition is significantly affected by SARS-CoV-2 infection and may be used to predict COVID-19 clinical evolution. Therefore, it will be possible to better allocate healthcare resources and better tackle future pandemics.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNNobre, José GuilhermeDelgadinho, MarianaSilva, CarinaMendes, JoanaMateus, VanessaRibeiro, EdnaCosta, Diogo AlpuimLopes, MiguelPedroso, Ana IsabelTrigueiros, FredericoRodrigues, Maria Inêsde Sousa, Cristina LinoBrito, Miguel2022-12-13T22:18:10Z2022-11-222022-11-22T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/146185eng1664-302XPURE: 48289937https://doi.org/10.3389/fmicb.2022.1035422info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:27:14Zoai:run.unl.pt:10362/146185Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:31.636943Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Gut microbiota profile of COVID-19 patients Prognosis and risk stratification (MicroCOVID-19 study) |
| title |
Gut microbiota profile of COVID-19 patients |
| spellingShingle |
Gut microbiota profile of COVID-19 patients Nobre, José Guilherme COVID-19 dysbiosis microbiome microbiota next generation sequencing prognosis risk stratification Microbiology Microbiology (medical) SDG 3 - Good Health and Well-being |
| title_short |
Gut microbiota profile of COVID-19 patients |
| title_full |
Gut microbiota profile of COVID-19 patients |
| title_fullStr |
Gut microbiota profile of COVID-19 patients |
| title_full_unstemmed |
Gut microbiota profile of COVID-19 patients |
| title_sort |
Gut microbiota profile of COVID-19 patients |
| author |
Nobre, José Guilherme |
| author_facet |
Nobre, José Guilherme Delgadinho, Mariana Silva, Carina Mendes, Joana Mateus, Vanessa Ribeiro, Edna Costa, Diogo Alpuim Lopes, Miguel Pedroso, Ana Isabel Trigueiros, Frederico Rodrigues, Maria Inês de Sousa, Cristina Lino Brito, Miguel |
| author_role |
author |
| author2 |
Delgadinho, Mariana Silva, Carina Mendes, Joana Mateus, Vanessa Ribeiro, Edna Costa, Diogo Alpuim Lopes, Miguel Pedroso, Ana Isabel Trigueiros, Frederico Rodrigues, Maria Inês de Sousa, Cristina Lino Brito, Miguel |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Nobre, José Guilherme Delgadinho, Mariana Silva, Carina Mendes, Joana Mateus, Vanessa Ribeiro, Edna Costa, Diogo Alpuim Lopes, Miguel Pedroso, Ana Isabel Trigueiros, Frederico Rodrigues, Maria Inês de Sousa, Cristina Lino Brito, Miguel |
| dc.subject.por.fl_str_mv |
COVID-19 dysbiosis microbiome microbiota next generation sequencing prognosis risk stratification Microbiology Microbiology (medical) SDG 3 - Good Health and Well-being |
| topic |
COVID-19 dysbiosis microbiome microbiota next generation sequencing prognosis risk stratification Microbiology Microbiology (medical) SDG 3 - Good Health and Well-being |
| description |
Funding Information: The authors acknowledge financial support from Instituto Politécnico de Lisboa that supported this project with the grant Microcovid. This project was also partially supported by FCT/MCTES (UIDB/05608/2020 and UIDP/05608/2020). Publisher Copyright: Copyright © 2022 Nobre, Delgadinho, Silva, Mendes, Mateus, Ribeiro, Costa, Lopes, Pedroso, Trigueiros, Rodrigues, de Sousa and Brito. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-13T22:18:10Z 2022-11-22 2022-11-22T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/146185 |
| url |
http://hdl.handle.net/10362/146185 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1664-302X PURE: 48289937 https://doi.org/10.3389/fmicb.2022.1035422 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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